Navigation Links
New clinical trial to test novel approach to treat triple-negative breast cancer
Date:6/2/2011

Baltimore, MD -- A multicenter clinical trial led by a researcher at the University of Maryland Marlene and Stewart Greenebaum Cancer Center will evaluate a new approach to treat triple-negative breast cancer, an often-aggressive type of cancer that is more common among African-Americans and young women. The study will help researchers determine if an experimental drug, entinostat, can reprogram tumor cells to express a protein called an estrogen receptor to make them sensitive to hormone therapy.

Saranya Chumsri, M.D., an oncologist at the Greenebaum Cancer Center and assistant professor of medicine at the University of Maryland School of Medicine, is the principal investigator of the newly opened National Cancer Institute-funded study. The trial is based on laboratory studies by Angela H. Brodie, Ph.D., an internationally recognized University of Maryland breast cancer researcher, and her colleagues. Their research, recently published in the journal Cancer Research, found that entinostat can cause triple-negative breast cancer cells to become sensitive to a hormone therapy such as an aromatase inhibitor. Dr. Brodie pioneered the development of aromatase inhibitors, a class of breast cancer drugs that reduces the level of estrogen produced by the body, thereby cutting off the fuel to cancer cells.

In this Phase II trial, doctors will treat newly diagnosed postmenopausal patients with entinostat and an aromatase inhibitor called anastrozole (Arimidex) before they have surgery to remove their cancer. Researchers will analyze tissue from the tumor and blood samples to evaluate whether the treatment is effective. After surgery, patients will receive standard treatment, such as chemotherapy and radiation.

"We hope that entinostat will make the tumor cells more sensitive to the drug anastrozole, causing the tumor to shrink or, at the very least, stop growing," Dr. Chumsri says. "For patients with triple-negative breast cancer, che
'/>"/>

Contact: Karen E. Warmkessel
kwarmkessel@umm.edu
410-328-8919
University of Maryland Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. The use of placebo in rheumatoid arthritis clinical trials may negatively impact patients
2. Clinical study suggests estrogen levels and breast health can be altered
3. Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia
4. New cancer drug discovered at U-M heads to clinical trials
5. JAMIA: Evaluating clinical information systems, patients who use PHRs, how clinicians use EHRs
6. Preview of oral presentations at the 1st IOF-ESCEO Pre-Clinical Symposium
7. Press registration open for clinical nutrition conference
8. Clinical Benefits of Zimmers DeNovo® NT Natural Tissue Graft in First Surgery Documented in Peer-Reviewed Publication
9. Media alert: ACMG 2011 Clinical Genetics Meeting -- press registration is now open
10. MedNet Solutions Announces Significant Enhancements to ENLIGHTEN, Its Flagship EDC / eClinical Solution
11. UTHealth, Athersys preclinical research on stem cell therapy for stroke presented at AHA conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New clinical trial to test novel approach to treat triple-negative breast cancer
(Date:5/22/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... promotional pricing and making the Wocket generally available for $229 ... Head of Marketing said, "We,ve extended the opportunity to take ... May. To get your wocket at this special price, submit ... on June 1, you,ll receive a unique code that gives ...
(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/21/2015)... , May 21, 2015 ... "Thermal Imaging Market by Solutions (Hardware, Software, Services), by ... Automotive & others), by End-Users (Military & Defense ... by MarketsandMarkets, Thermal Imaging Market is expected to ... Million by 2020, at a Compound Annual Growth ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 2NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 3Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4
... toying with the idea of designing biological molecules that ... Pennsylvania researchers have developed a way to form these ... more important, have developed a new microscope technique that ... devices. The research was conducted by Dawn Bonnell, ...
... 08, 2011) A team of scientists has developed a ... into 3-D spheres. Their discovery takes advantage of an earlier ... promises more accurate tests of new cancer therapies. As ... "Sometimes engineering research tends to be a case of a ...
... the term "mutation" to describe a change in an individual ... its DNA. But the term has also achieved a ... which individuals gain exceptional, often malign, characteristics. The idea ... of evolution by natural selection and in his new book ...
Cached Biology News:Penn researchers develop biological circuit components, new microscope technique for measuring them 2Penn researchers develop biological circuit components, new microscope technique for measuring them 3New 3-D tumor model 2Noted science historian Elof Carlson traces how the idea of mutation has changed in 6 generations 2
(Date:5/20/2015)... May 20, 2015 Research and Markets ... "Top Technologies in HW_Technical Insights" report to ... report evaluated technology trends in the Health and Wellness ... likely to have an impact in the year 2015. ... the top 10 health and wellness technologies that are ...
(Date:5/20/2015)... 20, 2015 The global genotyping market ... during the forecast period of 2015 to 2020 to ... used in drug discovery and development process and to ... In addition to this,heavy investments by key manufacturers to ... also propelling market growth. Browse 113 market data tables ...
(Date:5/20/2015)... Mass. , May 20, 2015  Haemonetics Corporation ... Concannon , President & CEO, will present at The ... York on June 1 st , 2015 ... may access Mr. Concannon,s presentation live via webcast at: ... Haemonetics (NYSE: HAE ) is a global ...
(Date:5/20/2015)... PARK, North Carolina , 20. ... führende Unternehmen für klinische Logistik (Clinical ... für das Geschäftsjahr 2014, das am ... eingereicht. Das Unternehmen hat die Marktentwicklung ... Logo - http://photos.prnewswire.com/prnh/20110930/NY78064LOGO ...
Breaking Biology Technology:Top Technologies in the Health and Wellness Industry 2015 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... Nov. 12 /Xinhua-PRNewswire/ -- WuXi PharmaTech (NYSE:,WX), a ... outsourcing company with operations in China and the ... Ying Han to its Board of,Directors., From ... Asiainfo as Chief,Financial Officer and Executive Vice President. ...
... Calif., Nov. 12 Beckman,Coulter, Inc. (NYSE: ... and marketer,of products that simplify, automate, and ... Slacik, Beckman Coulter,s senior vice,president and chief ... Capital,Markets 5th Annual Healthcare Conference on Tuesday, ...
... Nov. 12 SpineSmith Partners, an,innovative bio-medical ... teams in The University of Texas Biomedical ... design, engineering, and commercialization,process of medical devices., ... groups of biomedical engineering students will work ...
Cached Biology Technology:WuXi PharmaTech Appoints Ying Han to Its Board of Directors 2SpineSmith Partners Collaborates with University of Texas Biomedical Engineering Students to Develop Innovative Products 2
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. The ... as a one-cabinet model, allowing ...
... Beta-Agarase is useful in recovering DNA ... Beta-Agarase digests the agarose into oligo- ... Heat Inactivation: 65C, 15 min Molecular ... Purity: Tested for contaminating endonucleases, exonucleases ...
iEMS Thermal Microplate Holder...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
Biology Products: