Navigation Links
New clinical trial explores novel noninvasive colon cancer screening test

CLEVELAND In a first-of-its-kind clinical trial, physician-scientists at University Hospitals (UH) Case Medical Center's Seidman Cancer Center and Case Western Reserve University School of Medicine are studying a promising new non-invasive technology for colon cancer screening. The five-year study is recruiting patients to compare the effectiveness of stool DNA (sDNA) testing with colonoscopy for detecting large colon polyps.

SDNA is a novel test that detects colon cancer in its earliest stages, based on analysis of stool DNA. Developed in the laboratory of Sanford Markowitz, MD, PhD, oncologist with the UH Seidman Cancer Center and Professor at Case Western Reserve University School of Medicine, sDNA is a recommended screening by the American Cancer Society.

"Colon cancer is the second leading cause of cancer deaths in the United States but is a preventable disease," says Gregory Cooper, MD, Co-Program Leader for Cancer Prevention at UH Seidman Cancer Center and Professor at Case Western Reserve University School of Medicine. "Early detection through screening can prevent the development of colon cancer. This promising new test has the potential to improve colon cancer screening rates and decrease mortality from this deadly disease."

Colonoscopy is considered the gold standard for screening because of its ability to not only locate but remove precancerous polyps. All adults over age 50 should undergo colonoscopy, with certain risk factors for screening at an earlier age. However, according to research conducted by Dr. Cooper, many adults do not follow these national guidelines.

"Colonoscopy is truly the best test but it has its limitations and is vastly underutilized by the public," says Dr. Cooper, who is clinical Primary Investigator for the study. "SDNA technology is a completely non-invasive approach and a complement to colonoscopy. It is emerging as a promising alternative for patients who do not want to undergo colonoscopy or do not have access to the procedure. It also can be beneficial for patients during the years in between colonoscopies."

Dr. Markowitz, who is an alumnus investigator of the Howard Hughes Medical Institute, and his team played an intimate role in developing the new technology for DNA screening for colon cancer. They discovered a specific DNA change, methylation of the vimentin gene, which takes place in colon cancers, and then developed techniques for sensitively detecting this change in DNA shed from colon cancers in the stool. Their technology has been licensed by EXACT Sciences Corporation for commercial development and expanded to include a larger panel of genes.

"This is true translational research, bringing a discovery from the laboratory to the patient care setting," says Li Li MD, PhD, the study's basic investigator, family medicine physician at UH Case Medical Center and Associate Professor at Case Western Reserve University School of Medicine. "Information gained from this study may have significant and immediate implication for the clinical practice of screening and primary prevention of colon cancer."

The five-year study aims to recruit 1,600 patients who are scheduled for screening colonoscopy at UH Case Medical Center and UH community-based practices. Researchers will explore sDNA's efficacy in detecting large polyps, specifically advanced adenomas, which have a higher likelihood of progression to colorectal cancer.

The study is funded as part of the National Cancer Institute's Specialized Program of Research Excellence (SPORE) in Gastrointestinal (GI) Cancers award to Case Western Reserve University School of Medicine. The $11.3 million SPORE grant focuses on translational research aimed at reducing the incidence and deaths from colon cancers and from cancers of the esophagus.

"Among our guiding principles is to pursue and implement breakthrough medical advancements and practices to deliver superior clinical outcomes for our patients," said Stanton Gerson, MD, Director, UH Seidman Cancer Center and Case Comprehensive Cancer Center, Case Western Reserve University. "Non-invasive sDNA screening is an exciting example of this principle in action and potentially can have a dramatic impact on increasing screening rates and decreasing mortality."


Contact: Alicia Reale
University Hospitals Case Medical Center

Related biology news :

1. A new journal where molecular biology meets clinical research
2. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
3. Biochemistry of human physiology in health and disease is focus of updated clinical text
4. New book helps medical students master clinical skills
5. In just 5 years, gene discovery to clinical trial of potential treatment
6. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
7. Genome Medicine: Bridging the gap between research and clinical practice
8. 3 new informatics pilot projects to aid clinical and translational scientists nationwide
9. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
10. ABC publishes monograph on scientific and clinical research of Sinupret
11. Researchers win award for best clinical paper in orthopedic physical therapy
Post Your Comments:
(Date:10/29/2015)... 29, 2015  The J. Craig Venter Institute (JCVI) ... Synthesis and Biosecurity: Lessons Learned and Options for the ... and Human Services guidance for synthetic biology providers has ... --> --> Synthetic biology ... potential to pose unique biosecurity threats. It now is ...
(Date:10/29/2015)... NXTD ) ("NXT-ID" or ... the growing mobile commerce market and creator of ... leading marketplace to discover and buy innovative technology ... on StackSocial for this holiday season.   ... a biometric authentication company focused on the growing ...
(Date:10/27/2015)... Calif. , Oct. 27, 2015 Synaptics Inc. ... solutions, today announced that Google has adopted the Synaptics ... touch controller solutions to power its newest flagship smartphones, ... by Huawei. --> ... like Google to provide strategic collaboration in the joint ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) announced ... stockholder rights plan (Rights Plan) in an effort to ... (NOLs) under Section 382 of the Internal Revenue Code ... PharmAthene,s use of its NOLs could be substantially limited ... in Section 382 of the Code. In general, an ...
(Date:11/25/2015)... DIEGO , Nov. 25, 2015  Neurocrine Biosciences, ... Kevin Gorman , President and CEO of Neurocrine Biosciences, ... Healthcare Conference in New York . ... to visit the website approximately 5 minutes prior to ... A replay of the presentation will be available on ...
(Date:11/25/2015)... , November 25, 2015 ... Report is a professional and in-depth study on ...      (Logo: ) , ... the industry including definitions, classifications, applications and industry ... for the international markets including development trends, competitive ...
(Date:11/24/2015)... Nov. 24, 2015 Cepheid (NASDAQ: CPHD ... at the following conference, and invited investors to participate ...      Tuesday, December 1, 2015 at 11.00 a.m. ...      Tuesday, December 1, 2015 at 11.00 a.m. ... New York, NY      Tuesday, December ...
Breaking Biology Technology: