Navigation Links
New clinical data shows chromium picolinate improves cognitive function
Date:12/13/2007

PURCHASE, N.Y., December 13, 2007 Nutrition 21, Inc. (NASDAQ: NXXI), a leading developer and marketer of chromium-based and omega-3 fish oil-based nutritional supplements, today announced the results of a clinical study that showed daily supplementation with 1000 mcg of chromium as chromium picolinate improved cognitive function in older adults experiencing early memory decline. The results of the randomized, double-blind, placebo-controlled study were presented to the medical community at a neurological meeting.

Blood circulation and nutrient flow to the brain decrease as a result of aging, which can affect cognition. Previous studies have shown that chromium picolinate improves insulin sensitivity, which allows glucose, the brains main fuel, to be processed more efficiently.

Impaired glucose metabolism and insulin resistance have been linked to age-related cognitive decline, dementia and Alzheimers disease. These findings suggest that improving glucose metabolism with chromium picolinate supplementation may enhance cognition, said Robert Krikorian, Ph.D., lead investigator and associate professor, Department of Psychiatry, University of Cincinnati College of Medicine. These results are encouraging and indicate that further study of this intervention is warranted. Ultimately, we may find that chromium supplementation offers benefit to patients, given the prevalence of metabolic disorders and associated cognitive decline in the aging population.

In this study, investigators used Nutrition 21s proprietary chromium picolinate found in Core4Life Advanced Memory Formula, a nutritional supplement specifically formulated to improve brain health. Core4Life Advanced Memory Formula contains a unique combination of chromium picolinate, phosphatidylserine (PS) and DHA. These ingredients all play an important role in helping improve memory and maintain brain health. PS and DHA are major components of healthy brain cell membranes and increase communication between brain cells while chromium picolinate increases glucose metabolism.

The results of this clinical study support emerging research that shows chromium has direct effects on cognitive function, said James Komorowski, M.S., Vice President of Scientific Affairs at Nutrition 21. PS and DHA already have established associations with improved cognitive function and we are pleased to see the current findings substantiate the inclusion of chromium picolinate as a key ingredient in Core4Life Advanced Memory Formula.

About the Study

The randomized, double-blind, placebo-controlled study measured whether supplementation with chromium picolinate over a 12-week period might improve cognitive function in 21 adults aged 65 years and older with early memory decline. Study participants were asked to learn a list of words presented over several learning trials and, after a delay, were asked to remember the words. Those receiving the chromium picolinate supplement showed a trend for reduced interference from irrelevant words on the memory task (p = 0.12). In addition, on another task assessing fine motor control and speed, the subjects receiving chromium picolinate exhibited enhanced motor speed relative to those receiving placebo (p = 0.16).

Another component of the study measured brain activity. Functional magnetic resonance imaging (fMRI) scans were performed while subjects were working on a demanding cognitive task that involved holding in mind and manipulating information. Preliminary results from the fMRI scans of individuals from the chromium picolinate group and from the placebo group showed that the subjects receiving the active supplement exhibited greater activity in left frontal and left parietal cortices, areas of the brain associated with working memory. The subjects receiving placebo showed no such change.

At the completion of the study, chromium to creatinine ratios were significantly elevated in the chromium picolinate group (p = .008) indicating increased levels of chromium in the blood. The groups did not differ significantly with respect to age (73 versus 69 years), educational level (15.7 versus 15 years), stage and extent of memory impairment (Clinical Dementia Rating sum boxes score, 1.0 versus 0.85) or level of mood disturbance (Profile of Mood States total score, 18.4 versus 16.9).

About Core4Life Advanced Memory Formula

Core4Life Advanced Memory Formula, available in soft gel form, contains a proprietary blend of chromium picolinate, PS and DHA. These ingredients have been scientifically tested for their ability to improve cognitive function:

  • Chromium picolinate is an essential trace mineral that promotes healthy blood sugar, which is important because glucose helps fuel the brain.
  • PS is a naturally occurring phospholipid nutrient essential to the functioning of all cells of the body, but is most concentrated in the brain. PS supports communication between brain cells and promotes improved memory.
  • DHA is an omega-3 fatty acid, most commonly found in fish oil, which maintains brain fluidity and may help in the maintenance of cognitive function.

Core4Life Advanced Memory Formula is manufactured according to strict Food and Drug Administration (FDA) guidelines. This product can be taken safely alone or with medication, with optimal results seen in 30 to 90 days. Core4Life Advanced Memory Formula is available at major retailers nationwide in the vitamin section. For more information visit www.core4life-amf.com.


'/>"/>

Contact: Maryrose Lombardo
mlombardo@nutrition21.com
914-701-4525
Nutrition 21  
Source:Eurekalert

Related biology news :

1. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
2. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
3. Phase 2 of Singapores Biomedical Sciences Initiative gains momentum for clinical research
4. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
5. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
6. Study of African traditional medicine will begin world-first clinical trial
7. Research shows skeleton to be endocrine organ
8. Clones on task serve greater good, evolutionary study shows
9. Study shows link between alcohol consumption and hiv disease progression
10. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
11. New study shows greenback cutthroat trout involved in recovery effort misidentified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New clinical data shows chromium picolinate improves cognitive function
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
Breaking Biology Technology: