Navigation Links
New class of drug offers hope to treatment-resistant AIDS patients
Date:10/12/2007

y therapeutic agents.

In addition, for many AIDS patients, the long-term regimens of anti-HIV drugs prove toxic, and ultimately, their benefits decline. HIVs ability to rapidly mutate means that patients usually develop resistance to their treatments over time, explained Nair.

Now, with HIV integrase inhibitors, we have a new class of drugs for people that is expected to alleviate some of the problems associated with resistance and provide new treatment options, said Nair.

Integrase inhibitors are creating excitement in the pharmaceutical industry, scientific community and for patients, said Sohail Malik, director of technology commercialization for UGARF. Merck & Co. recently reported favorable Phase III clinical trials of Isentress, an experimental integrase inhibitor, and an independent advisory committee recommended approval. The U.S. Food and Drug Administration is currently reviewing the drugs safety and effectiveness, and approval is expected this month.

Drug developers have been targeting HIV integrase for years, but without much success. Nairs own discovery had its beginning in NIH-funded work as far back as 1994, while he was a researcher at the University of Iowa. But, he said of his early research, those compounds didnt sufficiently inhibit HIV replication in infected cells.

It wasnt until 2002 when he came to the College of Pharmacy at the University of Georgia that he began working on an entirely new class of HIV integrase inhibitors with further NIH research support and had a major breakthrough. All told, Nair, who directs UGAs interdisciplinary Center for Drug Discovery, has worked for over a decade to bring HIV integrase inhibitors to the point where they could be licensed, an important milestone in the drug discovery, development and approval process.

Because a patent lasts just 20 years from the date its filed, and further development and clinical trials take a number of years and sign
'/>"/>

Contact: Kim Osborne
kosborne@uga.edu
706-583-0913
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. Newly-discovered class of genes determines ?and restricts ?stem cell fate
3. An entropy-based gene selection method for cancer classification using microarray data
4. PANTHER Protein Classification System Database 5.0
5. Towards precise classification of cancers based on robust gene functional expression profiles
6. FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
7. Innovative collaboration brings Arctic science into the classroom
8. Lipids get new comprehensive classification system
9. Health costs soar as 60 million Americans classed as obese
10. New book expands biological classifications to account for alien life
11. New classification of eukaryotes has implications for AIDS treatment, agriculture and beyond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions ... the entire spectrum of clinical research, is proud to ... the company,s comprehensive SaaS-based eClinical technology platform, has led ... the first two quarters of 2015.   Q2 2015 ... largest quarters measured by contract value sold in the ...
(Date:8/10/2015)... BOSTON and TELTOW, Germany ... SensoMotoric Instruments (SMI), a world leader in Eye ... the completion of its OEM Eye Tracking Platform for ... Eye Tracking Platform contains reference designs for seamless integration ... kiosk systems, virtual reality HMDs and augmented reality smart ...
(Date:8/5/2015)... , August 5, 2015 According ... Access Management Market by Software, Services, Vertical (BFSI, Airport, IT ... Geography - Global Forecast to 2020", published by MarketsandMarkets, ... Market globally into various segments. The global PIAM Market ... to $546.2 Million by 2019, at a CAGR of ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... acetyl CoA carboxylase 2,or ACC2, appears to turn the ... in part why the animals can eat more and ... Medicine,researchers.,The report that appears online today in the Proceedings ... cells in these mice bred to lack ACC2," said ...
... University,of California, San Diego have invented a process ... of specialized cells being sought as possible,treatments for ... and Shu Chien, UCSD bioengineering professors, and Christopher,J. ... in a paper published in the February issue ...
... have discovered a way to overcome one of the ... kill normal cells in the,process of eradicating cancer cells.,In ... of the Proceedings of the,National Academy of Sciences (PNAS), ... into a specially designed,virus. The virus eradicated prostate cancer ...
Cached Biology News:Lack of enzyme turns fat cells into fat burners 2Priming embryonic stem cells to fulfill their promise 2Priming embryonic stem cells to fulfill their promise 3Columbia research lifts major hurdle to gene therapy for cancer 2
(Date:9/1/2015)... ... 01, 2015 , ... Research conducted by Synedgen Inc.’s Director ... School of Medicine, Frederick National Laboratory for Cancer Research, and the Centers for ... Access journal. , Christopher Ryan PhD, of Synedgen, and Aparajita Chatterjee, Daniel ...
(Date:8/31/2015)... ... August 31, 2015 , ... In ... its properties such as low carbon footprints and compostability. These properties can help ... based plastics. On the basis of applications, the market for biodegradable plastics can ...
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ) ... & Africa Biomedical Sensors Market - Growth, Trends & ... The Middle East & ... by 2018 at a CAGR of 3.26% over the ... Biomedical sensors that are adaptable to the genetic formulation ...
(Date:8/31/2015)... HAYWARD, Calif. and SHANGHAI ... Inc., a privately-held biopharmaceutical company developing next-generation antibiotics, ... Phase 2 clinical study for its lead drug ... designed to treat drug-resistant bacteria such as MRSA ... safer and better tolerated therapeutic option than currently ...
Breaking Biology Technology:Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2MicuRX Reports Positive Top-Line Results In Phase 2 Clinical Trial For Novel Antibiotic MRX-I In Complicated Skin And Soft Tissue Infections 2
... , , , 7.6.4 Long PCR , ... as desired with every temperature , command, enables a , ... , With Long PCR, this function can be used ... elongation. , , ...
... , , , , , ... set of conditions that can be applied to all PCR amplifications. For ... used, the annealing temperatures , of the PCRs can differ ... stringent annealing temperature is a prerequisite for reliable results , ...
... , , , , ... fragment using the PCR* are an everyday occurrence in the lab. For example, , ... which hinder, , or even prevent, further analyses (cycle ... of the PCR result. In such cases, PCR , ...
Cached Biology Technology:PCR Optimization 2PCR Optimization 3Using Gradient PCR to determine the optimum annealing temperature. 2
96 Well Plate Sterile, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
...
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
... Angle Polypropylene Rotor designed for use ... CL3/CL3R** and Centra-MP4/MP4R*. A translucent lid ... ,EXCLUSIVE polypropylene rotor design provides excellent ... autoclaved. Polypropylene rotors are fully ...
Biology Products: