Navigation Links
New class of biomolecules triggered in response to respiratory virus infection
Date:10/26/2010

possible from the DNA code. Unlike the genome, the transcriptome varies in different types of cells in the body and in accordance with ever-changing conditions inside and outside the cell. Peng recalled, "There were intensive discussions about what value the new whole-transcriptome analysis would add to our understanding of viral pathogenesis. After several exploratory analyses, we realized that many long non-protein coding RNAs also responded to SARS virus infection. We were so excited. The response had just been overlooked by people."

"People have not seriously looked at these long-non-protein coding RNAs during viral infection," Peng noted, "because so little is known about these RNAs in general and this type of RNA can't be monitored easily with typical technologies." Katze and his research team were able to use highly advanced technologies, namely next generation sequencing, to perform a whole-transcriptome analysis of the host response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection. The study was conducted in four strains of mice, some more susceptible to this virus or to the flu virus than others.

Through a comprehensive computational analysis of the data, the researchers observed that virus infection triggered about 500 long non-protein coding RNAs transcribed from known locations on the genome and about 1,000 from previously unspecified genomic regions.

"Using this approach," Katze noted, "we demonstrated that virus infection alters the expression of numerous long non-protein coding RNAs. These findings suggest that these RNAs may be a new class of regulatory molecules that play a role in determining the outcome of infection." The long non-protein coding RNAs may be helping to manage the infected animal's response to the virus, including the basic, first-line defense against infection the animal's innate, or inborn, immunity.

Another important finding was that the strains of more susceptib
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Why your boss is white, middle-class and a show-off
2. New research shows how gene function drives natural selection in important class of genetic elements
3. Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
4. CSHL scientists find a new class of small RNAs and define its function
5. New discovery may lead to new class of allergy drugs
6. Scientists uncover new class of non-protein coding genes in mammals with key functions
7. Compounds could be new class of cancer drugs
8. Study says middle class coral reef fish feel the economic squeeze
9. Reducing animal experiments through top-class research
10. Genetic switch potential key to new class of antibiotics
11. Nutrition experts propose new class of low-sugar drinks to help stem obesity and diabetes epidemics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New class of biomolecules triggered in response to respiratory virus infection
(Date:4/21/2015)... 2015 High crime rate, ... boosting access control systems market in Saudi ... recently published report by TechSci Research " Saudi Arabia Access ... control systems market in Saudi Arabia ... access control systems market in the Kingdom is growing ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... the battle of the sexes, African electric fish couples ... also engage in a sort of dueling "electric duet." ... and behavioral displays in breeding and nonbreeding Brienomyrus brachyistius, ... electric fields from a batterylike organ in their tails ...
... brain consists of billions of nerve cells enabling to ... experience, touch, smell or fear, millions of neurons in ... each other by chemical and electrical impulses to compute ... regions. With 20,000 - 25,000 genes in our genome, ...
... Board: NRGX) today announced the publication in the June 23 ... the first ever gene therapy trial for Parkinson’s disease and ... own brain cells for any adult neurodegenerative disease. , ... with advanced Parkinson’s disease demonstrated both a lack of adverse ...
Cached Biology News:Turn-ons and turn-offs for neurons 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 3Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 4
(Date:5/26/2015)... May 26, 2015   PDI , a ... announced that Oakwood Healthcare in Dearborn, ... winning entry in Delivering the Difference ... display excellence in building collaborative relationships between infection ... healthcare facilities.  Oakwood Healthcare,s infection ...
(Date:5/26/2015)... May 26, 2015 Pharmaco-Kinesis Corporation (PKC) announced ... convened at Shutters on the Beach in ... status of the Company,s innovative Metronomic Biofeedback Pump (MBP), ... deliver chemotherapy over time to a target site of ... and biofeedback system in real-time.  ...
(Date:5/26/2015)... LOS ANGELES , 26. mája 2015 /PRNewswire/ ... ďakuje v mene svojej rodiny prezidentom Barackovi Obamovi ... vyjadrenú v súvislosti so stratou Dr. Rongxiang ... - http://photos.prnewswire.com/prnh/20150522/218111 Dr. Xu ... svojej dobe a jeho odhodlanie v oblasti vedy ...
(Date:5/26/2015)... May 26, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: ... of regenerative medicine, today announced that all outstanding common ... exercised prior to their expiry on June 15, 2015, ... million. "We thank our shareholders for their ... CEO of Asterias. "This exercise of warrants represents a ...
Breaking Biology Technology:PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 2Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 4Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 5Dr. Rongxiang Xu, O legende 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 3
... March 20, 2012  Watson Pharmaceuticals, Inc. (NYSE: ... Inc. has received approval from the United States Food ... (ANDA) for Ibandronate 150mg tablets, the generic equivalent to ... product in the second quarter. BONIVA® 150mg tablets had ...
... 20, 2012 /PRNewswire-iReach/ -- FirstMark today ... for the multiple biomarker cardiovascular blood test PREvent. ... announcing the completion of the clinical study demonstrating ... risk of near-term (2-3 years) myocardial infarction, and ...
... MURRAY, Utah, March 20, 2012 Creative Bioscience, a leading ... hCG1234™ , African Mango Lean ™, African ... Diet 1234 ™ and its new Raspberry Ketone ... all Sprouts Farmers Markets locations across the West ...
Cached Biology Technology:Watson's Generic BONIVA® 150mg Receives FDA Approval 2Expanded Findings for FirstMark's Completed Clinical Study for Predicting Near-Term (2-3 Years) MI 2Expanded Findings for FirstMark's Completed Clinical Study for Predicting Near-Term (2-3 Years) MI 3Creative Bioscience All-Natural Dietary Supplements Now Available at Sprouts Farmers Market 2Creative Bioscience All-Natural Dietary Supplements Now Available at Sprouts Farmers Market 3
Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine Protease Regulators...
Rabbit polyclonal to HMGB1 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 3146 SwissProtID: P09429...
ERalpha (Ser 104/106)...
Agarose, pulse field, 250 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: