Navigation Links
New class of biomolecules triggered in response to respiratory virus infection
Date:10/26/2010

possible from the DNA code. Unlike the genome, the transcriptome varies in different types of cells in the body and in accordance with ever-changing conditions inside and outside the cell. Peng recalled, "There were intensive discussions about what value the new whole-transcriptome analysis would add to our understanding of viral pathogenesis. After several exploratory analyses, we realized that many long non-protein coding RNAs also responded to SARS virus infection. We were so excited. The response had just been overlooked by people."

"People have not seriously looked at these long-non-protein coding RNAs during viral infection," Peng noted, "because so little is known about these RNAs in general and this type of RNA can't be monitored easily with typical technologies." Katze and his research team were able to use highly advanced technologies, namely next generation sequencing, to perform a whole-transcriptome analysis of the host response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection. The study was conducted in four strains of mice, some more susceptible to this virus or to the flu virus than others.

Through a comprehensive computational analysis of the data, the researchers observed that virus infection triggered about 500 long non-protein coding RNAs transcribed from known locations on the genome and about 1,000 from previously unspecified genomic regions.

"Using this approach," Katze noted, "we demonstrated that virus infection alters the expression of numerous long non-protein coding RNAs. These findings suggest that these RNAs may be a new class of regulatory molecules that play a role in determining the outcome of infection." The long non-protein coding RNAs may be helping to manage the infected animal's response to the virus, including the basic, first-line defense against infection the animal's innate, or inborn, immunity.

Another important finding was that the strains of more susceptib
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Why your boss is white, middle-class and a show-off
2. New research shows how gene function drives natural selection in important class of genetic elements
3. Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo
4. CSHL scientists find a new class of small RNAs and define its function
5. New discovery may lead to new class of allergy drugs
6. Scientists uncover new class of non-protein coding genes in mammals with key functions
7. Compounds could be new class of cancer drugs
8. Study says middle class coral reef fish feel the economic squeeze
9. Reducing animal experiments through top-class research
10. Genetic switch potential key to new class of antibiotics
11. Nutrition experts propose new class of low-sugar drinks to help stem obesity and diabetes epidemics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New class of biomolecules triggered in response to respiratory virus infection
(Date:8/1/2014)... The Journal of Nutrition Education and Behavior (JNEB) ... Material (GEM) awards, which were presented at the Society ... Education Impact: Local to Global," in Milwaukee, Wisconsin, June ... recognize the authors of the best article and best ... members of the JNEB Journal Committee and Board of ...
(Date:8/1/2014)... 2014Biologists at The Scripps Research Institute (TSRI) have identified ... process in brown fat cells. , The study, ... of the Proceedings of the National Academy of ... "brown fat thermogenesis," which is of great interest to ... may also protect against diabetes. , "This finding offers ...
(Date:8/1/2014)... Provider Binary Biometrics is pleased to welcome Kevin Morris ... its mobile service capabilities and add more daily appointments, which will allow the ... new cities such as, but not limited to, Daytona Beach ... Deltona , Edgewater , Holly Hill ... , Oak Hill , Orange City , ...
Breaking Biology News(10 mins):Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3
... biological structures, like the brain or the eye, are ... have proposed various ways that so-called ,irreducibly complex, structures ... a new study proposes an alternative route. ... intricate, say authors Dan McShea and Wim Hordijk, some ...
... dioxide removal could be used under certain requirements to ... would not replace the bulk of actual emissions reductions. ... separate emissions control from the time and location of ... climate protection," says lead-author Elmar Kriegler. "You don,t have ...
... are adding statistical nuance to our understanding of how ... statistical model of Arctic temperature and how it relates ... cores, and lake sediments, Martin Tingley, a research associate ... Peter Huybers, Professor of Earth and Planetary Sciences, have ...
Cached Biology News:Study proposes alternative way to explain life's complexity 2Study proposes alternative way to explain life's complexity 3CO2 removal can lower costs of climate protection 2CO2 removal can lower costs of climate protection 3New research helps place modern temperatures into a more complete statistical framework 2
(Date:8/1/2014)... Glencoe Software, Inc. is pleased ... ( http://glencoesoftware.com/data-inpress.html ), a suite of data ... into on-line publications.  The suite comprises Glencoe ... Photo - http://photos.prnewswire.com/prnh/20140731/132410   ... The DataViewer is a browser-based ...
(Date:7/31/2014)... Today BioSpace , the leading life sciences employment and news website, ... sciences community in Illinois , Indiana ... Michigan , Minnesota , Missouri ... and Wisconsin . BioMidwest is a leader ... on BioSpace originating in this region in 2013. The life sciences sector ...
(Date:7/31/2014)... The ability to see through organs and even the ... well as fine-grained cellular structures has been a long-time ... Press July 31st in the journal Cell ... simple methods for making opaque organs, bodies, and human ... connections intact. The protocols could pave the way for ...
(Date:7/31/2014)... York , July 31, 2014 ... Transparency Market Research "Quantum Dots Market - Global Industry ... 2023," the market was valued at USD 88.5 million ... million by 2023, growing at a CAGR of 53.8% ... Quantum Dots Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html ...
Breaking Biology Technology:Glencoe Software Launches Data InPress 2Glencoe Software Launches Data InPress 3Midwest Biotech Leaders Featured On BioSpace Map 2See-through organs and bodies will accelerate biomedical discoveries 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4
... for optimal image clarity , Eagle Eye ... Jane Moores ,Stratagene , A new optical filter has been ... Still Video System that increases contrast and sensitivity when imaging,silver-stained ... II Still Video System,is currently sold with an optical filter ...
... quantities of pure high-kb DNA , Jeff Braman Scott ... kits are,designed to isolate up to 20 and 350 g, respectively, ... kits can also easily purify very,large plasmids, including cosmid DNA. , ... SuperCos I clone containing a 40-kb , ...
... pcmv-script PCR cloning kit , , Tanya Hosfield ... Cloning Systems, Inc. , , Stratagene has expanded the ... a new vector for high-efficiency cloning of PCR,fragments and ... kit uses a PCR cloning method ...
Cached Biology Technology:Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 2Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 3Easy Cosmid DNA Purification with StrataPrep Kits 2Mammalian Expression Vector for Efficient Cloning of PCR Fragments 2Mammalian Expression Vector for Efficient Cloning of PCR Fragments 3Mammalian Expression Vector for Efficient Cloning of PCR Fragments 4
Fingerprinting II Informatix optional matrix types module, is an optional module that adds external similarity and distance matrix functions to the Fingerprinting II Informatix software package....
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... 2-D standards consist of seven reduced, denatured ... carbonic anhydrase, rabbit muscle GAPDH, bovine muscle ... with pIs ranging from 4.5 to 8.5 ... 76,000. These 2-D standards provide calibrated references ...
Biology Products: