Navigation Links
New chimeric mouse model for human liver diseases, drug testing
Date:12/4/2007

red if only five percent of all hepatocytes would express the missing enzyme, he says.

In fact, thats the underlying principle of the Salk researchers new chimeric mouse. It is based on a murine model for hereditary tyrosinaemia type I, developed by researchers at Oregon Healthy & Science University. An enzymatic defect in the tyrosine catabolism results in a toxic accumulation of byproducts within hepatocytes unless the mice are treated with a drug called NBTC.

Withdrawing the drug allows to selectively expand hepatocytes that do not have this defect, such as transplanted human hepatocytes. Within three months of transplantation, up to 20 percent of the mouse liver is repopulated by human hepatocytes. But whats more, the transplanted cells keep producing a foreign protein slipped inside with the help of a lentiviral vector, the kind usually used for gene therapy. We are very excited about that aspect since very often cells shut off the production of proteins introduced as part of gene therapy, says Verma.


'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute  
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. A computer for your mouse!
2. Immune cells promote blood vessel formation in mouse endometriosis
3. Cancer-resistant mouse discovered
4. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
5. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
6. A new kind of rat model
7. JILA finds flaw in model describing DNA elasticity
8. Smithsonian researchers develop models to assess wetland health
9. Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
10. Simulating kernel production influences maize model accuracy
11. MIT model could improve some drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New chimeric mouse model for human liver diseases, drug testing
New chimeric mouse model for human liver diseases, drug testing
(Date:12/11/2009)... PAAs consumer demand for premium fruit increases, growers ... to market. And to boost their bottom line, ... can increase fruit quality while reducing labor costs. ... growers to produce larger, healthier fruit, is among ... significant impact on fruit production overhead, and, ultimately, ...
(Date:12/11/2009)... Western Reserve University has granted an 18-month, exclusive ... portfolio of insulin analogs. The company must reach ... to obtain an exclusive license on therapies designed ... Diabetes is developing treatments that it hopes will ... rapidly growing insulin market. Insulin is a therapeutic ...
(Date:12/11/2009)... 2009 Keystone Symposia on Molecular and Cellular ... five new Keystone Symposia Fellows for 2010. Launched ... early-career life scientists (postdoctoral trainees or assistant professors) ... for one year. Fellows are selected based on ... to promoting diversity in the biomedical and life ...
Breaking Biology News(10 mins):Horizontal string trimmer reduces labor costs, increases peach size 2Case Western Reserve University grants option to startup Thermalin Diabetes Inc. 2Keystone Symposia appoints 5 Fellows as part of diversity in life science initiative 2Keystone Symposia appoints 5 Fellows as part of diversity in life science initiative 3Keystone Symposia appoints 5 Fellows as part of diversity in life science initiative 4Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 1Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 2Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 3Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 4Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 5Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 6Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effec 62681 7Belluck 26amp 3B Fox Law Firm Urges Caution When Buying Toys This Holiday Season 62677 1Belluck 26amp 3B Fox Law Firm Urges Caution When Buying Toys This Holiday Season 62677 2Belluck 26amp 3B Fox Law Firm Urges Caution When Buying Toys This Holiday Season 62677 3New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 1New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 2New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 3New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 4New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 5New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 6New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 7New Research Demonstrates Advances in Optimizing Treatments and Quality of Life for People With Hard To Treat Forms of Blood Cancer 62675 8
... Without them, birds could not fly or attract mates. ... one current hypothesis, developmental biologists at University of Wisconsin ... In a previous study, UW anatomy professor John F. ... and bone morphogenetic protein 2 (Bmp2) must be expressed ...
... and tails, sauropod dinosaurs---famous as the Sinclair gasoline logo and ... because they all seem to look alike. , The ... common in North America during the middle of the dinosaur ... by more specialized plant-eaters at the end of that era. ...
... are more likely to bounce back from extreme coastal ... knowledge, according to a report published in Science. , ... valuable insight into handling extreme coastal disasters - inevitable ... by 2030 and global warming continues to exacerbate extreme ...
Other Biology News:Molecular mechanism of feather formation found 2Molecular mechanism of feather formation found 3Skull study sheds light on dinosaur diversity 2Skull study sheds light on dinosaur diversity 3Environmental lessons from tsunami as world's coastal population doubles 2
(Date:12/14/2009)... with State Biotech Leaders to Develop Blueprint ... Development while Boosting Rhode Island,s Growing Biotech ... R.I., Dec. 14 Several of ... medicine and biotechnology gathered today at Brown ... importance of medical innovation in Rhode Island ...
(Date:12/14/2009)... Decision Resources, one of the world,s ... healthcare issues, finds that, owing to the launches ... market will increase more than sevenfold from $790 ... in the United States, France, Germany, Italy, Spain, ... Pharmacor report entitled Atrial Fibrillation finds ...
(Date:12/11/2009)... miRagen Therapeutics, Inc., a biopharmaceutical company focused on ... for cardiovascular and muscle disease, today announced the ... a crucial role in the progression of amyotrophic ... in neuromuscular synaptic regeneration in mice. The ... the journal Science , reveal miR-206 as ...
(Date:12/11/2009)... Dec. 11 Marrone Bio Innovations (MBI) ... management team. Mr. Chris Hildreth joined MBI as ... responsible for expanding all commercial aspects of the ... Dr. Kin Sing (Ray) Lam joined MBI as ... company,s development efforts in scaling its broad pipeline ...
Breaking Biology Technology:Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 2Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 3Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 4The Atrial Fibrillation Drug Market Will Increase More Than Sevenfold, from $790 Million in 2008 to $6.1 Billion in 2018 2miRagen announces discovery of key microRNA implicated in Lou Gehrig's disease 2Marrone Bio Innovations Announces Two New Executive Appointments 2Marrone Bio Innovations Announces Two New Executive Appointments 3
... WuXi PharmaTech (Cayman) Inc.,(NYSE: WX ), ... development outsourcing company with operations in China and ... Philadelphia facility to,the Company,s expanding biologics testing, cell ... 31, 2008, WuXi will discontinue its U.S.,biologics manufacturing ...
... companies with substantial internal mammalian cell culture ... manufacturing capacity. Contract mammalian cell culture manufacturers ... pressure of increased utilization rates. For these ... understanding critical demand drivers, market factors and ...
... 1, 2008 Imagine a self-powering cell phone that ... waves produced by the user into the energy it ... it may seem thanks to the recent work of ... of Chemical Engineering at Texas A&M University. , Utilizing ...
Other Biology Technology:WuXi PharmaTech Will Focus U.S. Operations on Laboratory Testing Services 2WuXi PharmaTech Will Focus U.S. Operations on Laboratory Testing Services 3WuXi PharmaTech Will Focus U.S. Operations on Laboratory Testing Services 4WuXi PharmaTech Will Focus U.S. Operations on Laboratory Testing Services 5PharmSource and BioProcess Technology Consultants Announce Publication of New Market Report: Cell Culture Manufacturing Capacity: Trends and Outlook through 2013 2Self-powered devices possible, says Texas A&M researcher 2Self-powered devices possible, says Texas A&M researcher 3
...
... pLivSelect is a direct antibiotic-based selection ... solely on colony survival, eliminating the need ... inexpensive process provides close to 100% accuracy ... ideal platform for robot colony picking. This ...
... antibiotic-based selection system for recombinant identification. Recombinant ... the need for costly color screening. This ... 100% accuracy in recombinant selection. pLivSelect is ... picking. This cloning kit can be used ...
... PCR plate, Directly compatible with ABI thermal ... for improved sealing characteristics can be ... or cap strips, Certified free of DNase, ... part of Thermo Fisher Scientific, the world ...
Biology Products: