Navigation Links
New chimeric mouse model for human liver diseases, drug testing
Date:12/4/2007

La Jolla, CA Cells cultured in the lab are like a fish out of water. Often, their behavior does not reflect their biological function within an entire organ or organism, which, for example, turns studying human liver cells into a big challenge.

One way to get around the altered properties of the stranded cells is to populate mouse livers with human hepatocytes in the hope of creating a natural environment, which is exactly what researchers at the Salk Institute for Biological Studies did. They developed a simple system that allows them to transplant human hepatocytes into immunodeficient mice, which can now be used to test how drugs affect the liver.

Rodents are often used as model organisms to study the efficacy and toxicity of drugs, says lead author Karl-Dimiter Bissig, M.D. Ph.D., a postdoctoral researcher in the Laboratory of Genetics, but mouse and rat hepatocytes may function in very different ways when it comes to metabolism of drugs.

In the past, this has led to unexpected toxicity problems, when drugs moved into clinical trials after toxicity tests in rats failed to reveal adverse effects (e.g. Troglitazone). But it also worked the other way around. The clinical introduction of furosamide, a powerful but perfectly safe diuretic, has been slowed down because of its hepatotoxicity in rats, says Bissig.

The work, which will be published in this weeks online edition of the Proceedings of the National Academy of Sciences also holds promise for a better understanding of infectious diseases that affect the liver. It is basically impossible to grow human hepatocytes in the lab, which was a big hurdle for the study of viruses such as hepatitis A and hepatitis B, says senior author Inder Verma, Ph.D., a professor in the Laboratory of Genetics.

But most importantly, Bissig says, the mice will be an invaluable tool to advance regenerative medicine. Many inherited disorders affecting liver metabolism could be cu
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute  
Source:Eurekalert

Page: 1 2

Related biology news :

1. A computer for your mouse!
2. Immune cells promote blood vessel formation in mouse endometriosis
3. Cancer-resistant mouse discovered
4. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
5. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
6. A new kind of rat model
7. JILA finds flaw in model describing DNA elasticity
8. Smithsonian researchers develop models to assess wetland health
9. Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
10. Simulating kernel production influences maize model accuracy
11. MIT model could improve some drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New chimeric mouse model for human liver diseases, drug testing
(Date:9/29/2014)... 2014 Growing Demand From ... Increasing Security Concerns Continue to Propel Biometrics Market ... is one of the fastest growing biometrics ... systems, majorly in various government projects such as ... based biometrics dominates the country,s biometrics market, with ...
(Date:9/29/2014)... release is available in French . ... - The number of days an expectant mother was ... the epigenetic profile of her child, a new study ... and McGill University have detected a distinctive ,signature, in ... the massive Quebec ice storm. Five months after the ...
(Date:9/28/2014)... at the University of California, Santa Cruz, suggest that ... genomes of primates drove the evolution of complex regulatory ... cell of our bodies. , The arms race ... "jumping genes") and the genes that have evolved to ... the first time, identified genes in humans that make ...
Breaking Biology News(10 mins):India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3Human genome was shaped by an evolutionary arms race with itself 2Human genome was shaped by an evolutionary arms race with itself 3Human genome was shaped by an evolutionary arms race with itself 4
... to combat osteoporosis and other human common diseases is ... project "BlueGenics" which has received funding of EUR 6 ... team, coordinated by Professor Dr. Werner E.G. Mller from ... Medical Center, intends to identify and to utilize genetic ...
... believe that this knowledge may be important for the ... health issues, that modern science still hasn,t been able ... Center for Infectious Medicine at Karolinska Institutet and the ... time, it,s important to emphasize that humans have lived ...
... 2012 More than 100 academic institutions and ... initiative: Mathematics of Planet Earth (MPE) 2013. This ... mathematics in tackling global problems, including natural disasters ... sustainability; and pandemics. MPE2013 partners will sponsor workshops, ...
Cached Biology News:Launch of the EU large-scale integrating project 'BlueGenics' to combat osteoporosis 2Launch of the EU large-scale integrating project 'BlueGenics' to combat osteoporosis 3How the common 'cat parasite' gets into the brain 2Mathematicians tackle global issues 2Mathematicians tackle global issues 3
(Date:9/29/2014)... in Iraq and Afghanistan, more than 300,000 soldiers have ... caused by exposure to bomb blasts and in ... of traumatic brain injury can range from the mild, ... impairments in memory and cognition. , Since 2007, ... importance and complexity of this problem, and has made ...
(Date:9/29/2014)... food security, emerging diseases and biodiversity loss requires ... in Science Express that was co-authored ... College of Agriculture and Life Sciences. , For ... scientists has reviewed progress in addressing a broad ... management using approaches that consider evolutionary histories and ...
(Date:9/29/2014)... (PRWEB) September 29, 2014 Transparency Market ... Synthesis - SPPS, LPPS, HPPS, by Application - Cancer, ... & Generic and by Delivery) - Global Industry Analysis, ... states that the global peptide therapeutics market was worth ... US$25.4 billion by 2018 at an 8.7% CAGR. , ...
(Date:9/29/2014)... , Sept. 29, 2014 /PRNewswire/ - SQI Diagnostics Inc. ... develops and commercializes proprietary technologies and products for advanced ... Peter Winkley to Chairman of the Board ... Mr. Ricks will continue to serve as a Director ... to the Company.  "We are very ...
Breaking Biology Technology:Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 2Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 3SQI Diagnostics Announces New Chairman of Board of Directors 2
... by hiring laboratory reagent and diagnostics industry veteran , ... ... Inc., a high-tech provider of rapid prototyping and manufacturing services ... President of Operations. Dr. Anderson brings years of entrepreneurial and ...
... for November 6, 2008 at 10:00 a.m. EST, EAST ... ) today reported financial results for,the three and nine months ... of 2008 was $18.2 million or $0.34 per basic and ... net loss of $14.6,million or $0.28 per basic and diluted ...
... announced today the,submission of the response to the ... in Single Dose Containers). In an,Approvable Letter received ... with respect to chemistry, manufacturing, and controls (CMC)., ... complete response as a Class 2,resubmission, under which ...
Cached Biology Technology:ALine, Inc. Expands Management, Adding Roger Anderson, Ph.D., as VP of Operations 2Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 2Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 3Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 4Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 5Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 6Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 7Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 8Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 9Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 10SALVAT Announces Submission of Complete Response to FDA Approvable Letter for CETRAXAL(R) 2
... stain kits are optimized for use ... Dodeca stainers. This silver stain kit ... in polyacrylamide gels and are mass ... concentrate, silver reagent concentrate, background reducer ...
... This PTC-100 thermal cycler holds 96 x ... Hot Bonnet heated lid incorporates a thumbwheel ... seal PCR vessels for oil-free cycling. Peltier ... NIST-traceable calibration and ramping rates of up ...
BioGenex IHC Kits for Rodent Tissues are designed for immunohistochemistry on rodent and rabbit tissues that are closely related to the source of the primary antibody. This kit comes with rat seconda...
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
Biology Products: