Navigation Links
New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
Date:4/17/2008

Berlin, Germany: Adding capecitabine, a drug that inhibits DNA synthesis and slows the growth of tumour tissue, to docetaxel, in patients with early breast cancer, leads to more toxicities and does not improve the efficacy of treatment, a German scientist told the 6th European Breast Cancer Conference (EBCC-6) today (Thursday 17 April). Previously, such a combination had improved patient survival in metastatic disease, where the cancer has spread to other parts of the body.

Professor Gunter von Minckwitz, Chairman of the German Breast Group, Neu-Isenberg, Germany, and his team set out to look at the use of the combination in early breast cancer. We recruited 1510 patients with previously untreated primary tumours, he said. Each received the normal preoperative treatment of four cycles of epirubicin and cyclophosphamide. We then randomised them to either four cycles of docetaxel alone, four cycles of simultaneous docetaxel and capecitabine, or four cycles of docetaxel followed by four cycles of capecitabine. If capecitabine were to improve outcomes, we wanted to see how best to use it simultaneously or in sequence.

The scientists planned to study the pathologic response at surgery the way, if any, in which the tumour had reacted to the administration of the chemotherapy drug.

However, we found no difference in efficacy between the three arms of the trial with regard to pathologic response, clinical response, and rate of breast conservations, said Professor von Minckwitz. The overall rate of pathologic complete responses (pCRs) no cancer in the breast or lymph nodes was 29.7%.

Nor did the length of treatment appear to make a statistically significant difference. What the scientists did find was that the addition of capecitabine to the chemotherapy regime produced more non-haematological toxicities for example hand-foot syndrome, a skin reaction that appears on the palms of the hands and soles of the feet, and
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2

Related biology news :

1. A search for protection against chemotherapy cardiotoxicity
2. UC health news: molecular pathway may predict chemotherapy effectiveness
3. Insecticide combo delivers knockout punch
4. Cigarette smoke, alcohol damage hearts worse as combo
5. New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume
6. Extract of broccoli sprouts may protect against bladder cancer
7. A compound extracted from olives inhibits cancer cells growth and prevents their appearance
8. Videos extract mechanical properties of liquid-gel interfaces
9. 4 health behaviors can add 14 extra years of life
10. Bilberry extract -- can it help prevent certain cancers?
11. Research team says extraterrestrial impact to blame for Ice Age extinctions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... University of California, San Diego, have developed a program ... the activity of genes based on sequences of DNA. ... application to human embryonic cells in a paper published ... "All of our cells have the same blueprint, the ... Whitaker, lead author of the report. "Skin cells protect, ...
(Date:9/21/2014)... researchers has developed a protein therapy that disrupts the ... original tumor sites, travel through the blood stream and ... This process, known as metastasis, can cause cancer to ... patients who succumb to cancer fall prey to metastatic ... professor of bioengineering who describes a new therapeutic approach ...
(Date:9/19/2014)... of Oklahoma biology professor will study multifunctional and ... movements with a National Science Foundation grant in ... , Ari Berkowitz, professor in the Department of ... focus on the differences between the multifunctional and ... neurotransmitters they use and what connections they make. ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4
... to save a species in the 21st century? The specter ... as 35 percent, has some scientists and managers considering taking ... relocation (MR) is literally the physical relocation of endangered or ... and foreign geographical climes. It addresses the concern that climate ...
... at the National Institutes of Health have found that ... cell energy metabolism appear to increase the risk for ... the enzyme phosphodiesterase 11A (PDE11A), which helps regulate a ... studies by NIH researchers have linked genetic variations that ...
... greatly from our real-life partner, according to new research from ... France. The research found that our actual partners are of ... we would ideally choose. The study, which was ... PLoS ONE , found that most men and women express ...
Cached Biology News:Climate change forcing a 'move it or lose it' approach to species conservation? 2Climate change forcing a 'move it or lose it' approach to species conservation? 3Gene variations that alter key enzyme linked to prostate cancer 2Study shows real partners are no match for ideal mate 2
(Date:9/22/2014)... have developed a unique nanoscale device that for ... The discovery could have major implications for creating ... and communication. , The research paper by University ... Mo Li and his graduate student Huan Li ... the October issue of Nature Nanotechnology . ...
(Date:9/22/2014)... 2014 US demand to rise 3.9% annually ... is forecast to rise 3.9 percent per year to ... projected to increase 1.3 percent per year to 1.5 ... in construction expenditures will support demand for biocides in ... growth in consumer spending and manufacturing output will support ...
(Date:9/22/2014)... -- Research and Markets has announced the ... Industry Report 2014" report to their offering. ... Report 2014 is a professional and in-depth study on ... with a focus on the Chinese situation. ... including definitions, classifications, applications and industry chain structure. The ...
(Date:9/22/2014)... D.C (PRWEB) September 22, 2014 FierceBiotech ... top privately held biotechnology companies of 2014. FierceBiotech ... companies before selecting this year’s winners. Those selected ... biotechnology companies in the industry. , "It's ... new group of Fierce 15 companies," said Carroll. "This ...
Breaking Biology Technology:Engineers show light can play seesaw at the nanoscale 2US Biocides Market 2US Biocides Market 3Global and Chinese Microcrystalline Cellulose Industry Report 2014 2FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2
... industry will face many serious issues over the next ... rigors of engineering better biofuels and bioproducts. But few ... the 20,000 convention visitors at BIO '06. , ... ,A walk-through in Chicago's massive McCormick Place demonstrates just ...
... and discovery. From medicine to manufacturing, some of the ... our state. Today, amid a revolution in biotechnology and ... ,From developing innovative new sources of renewable energy that ... oil to working to find cures to Parkinson's, Alzheimer's ...
... Chicago The biotechnology industry has a job to ... luncheon attended by thousands at the BIO Chicago conference. , ... infectious diseases, guard against pandemics, create crops that can feed ... such as ethanol, and confront global warming head on. , ...
Cached Biology Technology:My-oh, it's BIO! Where sales hype and science collide 2Making Wisconsin the biotechnology leader 2Making Wisconsin the biotechnology leader 3Clinton says world needs biofuels, GM crops, and more answers 2Clinton says world needs biofuels, GM crops, and more answers 3
Rabbit polyclonal to STUB1 ( Abpromise for all tested applications). entrezGeneID: 10273 SwissProtID: Q9UNE7...
... which pioneered the blending of thermostable DNA ... Expand Long Template PCR Systems, now introduces ... the first product of a family of ... combines Taq DNA Polymerase with a novel ...
... polymers) are prepared by ... the enzyme, polynucleotide phosphorylase, ... the appropriate, ribonucleoside diphosphate ... exception of catalog number ...
... stainless-steel shaker flask clips, purpose-designed to firmly ... All clips are equipped with a top ... include a bottom retainer spring, and silicon ... expensive glassware. Clips include the required ...
Biology Products: