Navigation Links
New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
Date:4/17/2008

Berlin, Germany: Adding capecitabine, a drug that inhibits DNA synthesis and slows the growth of tumour tissue, to docetaxel, in patients with early breast cancer, leads to more toxicities and does not improve the efficacy of treatment, a German scientist told the 6th European Breast Cancer Conference (EBCC-6) today (Thursday 17 April). Previously, such a combination had improved patient survival in metastatic disease, where the cancer has spread to other parts of the body.

Professor Gunter von Minckwitz, Chairman of the German Breast Group, Neu-Isenberg, Germany, and his team set out to look at the use of the combination in early breast cancer. We recruited 1510 patients with previously untreated primary tumours, he said. Each received the normal preoperative treatment of four cycles of epirubicin and cyclophosphamide. We then randomised them to either four cycles of docetaxel alone, four cycles of simultaneous docetaxel and capecitabine, or four cycles of docetaxel followed by four cycles of capecitabine. If capecitabine were to improve outcomes, we wanted to see how best to use it simultaneously or in sequence.

The scientists planned to study the pathologic response at surgery the way, if any, in which the tumour had reacted to the administration of the chemotherapy drug.

However, we found no difference in efficacy between the three arms of the trial with regard to pathologic response, clinical response, and rate of breast conservations, said Professor von Minckwitz. The overall rate of pathologic complete responses (pCRs) no cancer in the breast or lymph nodes was 29.7%.

Nor did the length of treatment appear to make a statistically significant difference. What the scientists did find was that the addition of capecitabine to the chemotherapy regime produced more non-haematological toxicities for example hand-foot syndrome, a skin reaction that appears on the palms of the hands and soles of the feet, and
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. A search for protection against chemotherapy cardiotoxicity
2. UC health news: molecular pathway may predict chemotherapy effectiveness
3. Insecticide combo delivers knockout punch
4. Cigarette smoke, alcohol damage hearts worse as combo
5. New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume
6. Extract of broccoli sprouts may protect against bladder cancer
7. A compound extracted from olives inhibits cancer cells growth and prevents their appearance
8. Videos extract mechanical properties of liquid-gel interfaces
9. 4 health behaviors can add 14 extra years of life
10. Bilberry extract -- can it help prevent certain cancers?
11. Research team says extraterrestrial impact to blame for Ice Age extinctions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... Integrated Biometrics patented LES (Light Emitting ... film transistor camera introduces Sherlock, a fingerprint scanner ... the smallest and lightest form factor available on ... ID FAP 45, Certified scanner is highly efficient ... weight when compared to optical scanners. ...
(Date:5/16/2013)... world are meeting next week in Toronto. The ... latest in research findings about the brain, the ... disorders that affect them., "Canada is a leader ... the best of neuroscience research done here and ... the Canadian Association for Neuroscience. He also reminds ...
(Date:5/15/2013)... gout risk, new research reveals that vitamin C, also ... levels to a clinically significant degree in patients with ... with allopurinol, appears to have a weak effect on ... the results published in the American College of Rheumatology ... Gout is an inflammatory arthritis that causes excruciating pain ...
Breaking Biology News(10 mins):7th Annual Canadian Neuroscience Meeting, Toronto, May 20-24, 2013 2Vitamin C does not lower uric acid levels in gout patients 2
... Indian announced that it has been awarded a ... Building Council and verified by the Green Building ... Design, is the nation,s preeminent program for the ... "This achievement not only signifies the Smithsonian ...
... 6, 2011Measurable changes in brain function and communication between ... during the early stages of human immunodeficiency virus (HIV) ... are detailed in an article in the groundbreaking new ... bimonthly peer-reviewed journal published by Mary Ann Liebert, ...
... reduce size and improve performance and cell life is ... by Penn State and funded by the Department of ... $5 million, three-year grant is part of the DOE,s ... improving fuel efficiency of next generation vehicles. Penn ...
Cached Biology News:National Museum of the American Indian awarded prestigious LEED Green Building Certification 2Changes in brain function in early HIV infection: A reliable indicator of disease prognosis? 2
(Date:5/16/2013)... , May 16, 2013  HealthSparq, a ... of the nation,s largest regional health plans, will ... Health Insurance Plans (AHIP) Institute 2013 conference on ... survey results showing how health insurance companies across ... the consumer and marketplace demands for increased healthcare ...
(Date:5/16/2013)... 16, 2013 As the weather warms, women ... favorite Spring looks. While most make a statement with fashion, ... women find the warmer weather mixes makeup and sweat to ... the onset of acne during warmer months, Adult Acne ... treatment users the best ways to deter breakouts. , ...
(Date:5/16/2013)... 16, 2013 Reportlinker.com announces ... is available in its catalogue: ... for Acute Coronary Syndromes - APAC ... http://www.reportlinker.com/p01182969/MediPoint-Diagnostic-Cardiac-Biomarkers-for-Acute-Coronary-Syndromes---APAC-Analysis-and-Market-Forecasts.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic MediPoint: ... Syndromes - APAC Analysis and Market ...
(Date:5/16/2013)... 16, 2013 Dr. Stephen Y. Chou, ... titled “Nanoimprint Lithography and Applications” at IEEE Nano 2013 ... invented in 1995 by Chou, is becoming one of ... unique combination of sub-10 nm resolution, large area, and ... impacting both R&D and manufacturing in a broad range ...
Breaking Biology Technology:HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 2MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 3MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 4MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 5MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 6MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 7MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 8Founder, Prof. Stephen Chou to Give Tutorial on Nanoimprint at IEEE Nano 2013 2
... NEW YORK, May 13 Johnson & Johnson ... and Emeritus Professor Sir,Ravinder N. Maini, FRCP, FMedSci, ... London have been named the recipients of the,2008 ... an independent,selection committee of world-renowned scientists., The ...
... Ltd.,announced today the appointment of Prof. Arie Schachner to ... Dr. Schachner has been a member of Meditor,s Scientific ... active role in the Clinical Development,program., Prof. Schachner ... at Wolfson Medical Center and Tel Aviv University Sackler,Medical ...
... Calif., May 12 Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ... March 31, 2008 and provided an update on the,Company,s ... the 2008,first fiscal quarter, as reported in accordance with ... $14.6 million, compared,to a net loss of $10.9 million ...
Cached Biology Technology:Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research 2Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research 3Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research 4Two New Appointments at Meditor Pharmaceuticals Ltd. 2Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 2Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 3Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 4Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 5Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 6Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 7Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 8Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 9Alexza Reports 2008 First Quarter Financial Results and Updates Development of Product Candidates 10
...
... Immunogen: purified recombinant human ... coli . Physical form: ... filtered solution in phosphate buffered ... (c). WB. Titertest ...
Request Info...
2 ml SmartScan Racks...
Biology Products: