Navigation Links
New chemo drug gentler on fertility, tougher on cancer
Date:3/22/2013

CHICAGO --- A new gentler chemotherapy drug in the form of nanoparticles has been designed by Northwestern Medicine scientists to be less toxic to a young woman's fertility but extra tough on cancer. This is the first cancer drug tested while in development for its effect on fertility using a novel in vitro test.

The scientists designed a quick new in vitro test that predicts the toxicity of a chemotherapy drug to fertility and can be easily used to test other cancer drugs in development as well as existing ones. Currently the testing of cancer drugs for fertility toxicity is a time and resource intensive process.

"Our overall goal is to create smart drugs that kill the cancer but don't cause sterility in young women," said Teresa Woodruff, a co-principal investigator of the study and chief of fertility preservation at Northwestern University Feinberg School of Medicine. The paper was published March 20 in in the journal PLOS ONE.

The scientists hope their integration of drug development and reproductive toxicity testing is the beginning of a new era in which chemotherapy drugs are developed with an eye on their fertotoxity (fertility toxicity). As cancer survival rates increase, the effect of cancer treatments on fertility is critically important to many young patients.

Woodruff and Thomas O'Halloran, also a co-principal investigator and director of the Chemistry of Life Processes Institute at Northwestern, are a wife and husband team who developed and tested the drug. Their intersecting interests -- hers in fertility preservation, his in cancer drug development -- percolated over dinner conversations and sparked the collaboration.

O'Halloran also is the associate director for basic sciences research at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and Woodruff is the Thomas J. Watkins Memorial Professor of Obstetrics and Gynecology at Feinberg. Richard Ahn, now a fou
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
2. New way to kill lymphoma without chemotherapy
3. Neutrons help explain why antibiotics prescribed for chemotherapy cause kidney failure
4. Researchers reveal a chemo-resistant cancer stem cell as cancers Achilles heel
5. Scientists uncover strategy able to dramatically reduce chemotherapys side effects
6. New biomarker for common lung cancer predicts responses to chemotherapy
7. Nanobubbles plus chemotherapy equals single-cell cancer targeting
8. Harmless human virus may be able to boost the effects of chemotherapy
9. Our coral reefs: In trouble - but tougher than we thought
10. New study highlights strong anti-cancer properties of soybeans
11. St. Jude Childrens Research Hospital announces issuance of US patent for cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... N.Y. , Oct. 15, 2014 ... solutions for home and community-based care, today announced ... of implementing Sandata,s Santrax® Electronic Visit Verification™ Solution ... Services is a home health company founded in ... Texas . The study ...
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology ... today announced the availability of the VeriLook ... Surveillance 3.0 provides real-time biometric face identification using ... digital surveillance cameras. The new version not only ... differentiates people from objects while they are moving ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3
... On June 28-30, 2011 , the New York ... from a wide range of subspecialties, in addition to ... advances in our understanding of the clinical features, management, ... multiple organ systems and affecting children and young adults. ...
... Amsterdam, June 22, 2011 Elsevier, a world-leading provider ... in association with the Australian Society for Parasitology, is ... International Journal for Parasitology: Drugs and Drug Resistance ... affiliated with the leading parasitology journal, International Journal ...
... A new technique developed at Rensselaer Polytechnic Institute allows ... nanoscale bone samples. Along with adding important ... opens up an entirely new proteomics-based approach to analyzing ... forensic study of human skeletons. "We,re able to ...
Cached Biology News:New York Academy of Sciences hosts a conference on rare disease Shwachman-Diamond Syndrome 2Elsevier launches International Journal for Parasitology: Drugs and Drug Resistance 2New technique yields troves of information from nanoscale bone samples 2New technique yields troves of information from nanoscale bone samples 3
(Date:10/19/2014)... 2014 The Asian Automatic patient billing ... analysis and forecast of revenue. The Automatic patient billing ... $463.9 million by 2018, at a developing CAGR of ... TOC of the Asian Automatic patient billing market, to ... also provides a glimpse of the segmentation of this ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The report ... Market Share, Trade, Prices, Geography Trend and Forecast (2011 ... sales category, and geography and studies the major market ... North America, Europe, and Asia. , The global chocolate ... 2010.to $98.3 billion in 2016 at an estimated CAGR ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The ... Defense, & Homeland Security), Technology, Payload, Type & ... and segments the global unmanned ground vehicle market ... and forecasting of market sizes. The report also ... and opportunities impacting it along with the adoption ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, ... Human Insulin (Rapid Acting, Long Acting, Premixed)], by ... - Forecast to 2018” provides a detailed overview ... market trends, and strategies impacting the global human ... of the revenue and share analysis. , The ...
Breaking Biology Technology:The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... the world over are striving to develop organic solar cells ... that could be widely used to generate electricity. But ... form the proper structure at the nanoscale (tinier than 2-millionths ... to electricity. The goal is to develop cells made from ...
... , , , , ... Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on ... 30, 2009, and provided a corporate update. , , ... we reported promising Phase 2 picoplatin data from our colorectal and ...
... , LYNBROOK, N.Y., Aug. 4 ... biopharmaceutical company developing first in class collagenase-based products, announced today ... audio webcast at 4:30 p.m. ET on Wednesday, August 12, ... corporate highlights. , , To participate ...
Cached Biology Technology:Plastics that convert light to electricity could have a big impact 2Plastics that convert light to electricity could have a big impact 3Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 2Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 3Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 4Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 5Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 6Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 7Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 8BioSpecifics Technologies Corp. to Host Conference Call to Report Second Quarter 2009 Financial Results on August 12, 2009 2
Collected from sexually matured, mixed breed, mixed sex guinea pigs....
Enables rapid purification of double-stranded DNA fragments = 200 bp, including, for example, PCR reaction products, DNA fragments obtained in restriction enzyme digests, or double-stranded cDNA...
...
BD IMag Anti-Mouse CD90.2 (Thy1.2) Particles-MSC 2 x 109 cells...
Biology Products: