Navigation Links
New cell type offers immunology hope
Date:6/14/2011

A team of Australian scientists has discovered a new type of cell in the immune system.

The new cell type, a kind of white blood cell, belongs to a family of T-cells that play a critical role in protection against infectious disease.

Their findings could ultimately lead to the development of novel drugs that strengthen the immune response against particular types of infectious organisms.

It is also potentially significant for many other important diseases including allergies, cancer and coronary artery disease.

The research team includes Dr Adam Uldrich and Professor Dale Godfrey from the University of Melbourne, Dr Onisha Patel and Professor Jamie Rossjohn from Monash University and Professor Mark Smyth from the Peter MacCallum Cancer Institute.

The discovery, published in the international journal Nature Immunology, is a fundamental advance in understanding the different components of the immune system and how this system casts a net wide enough to catch all kinds of different infectious organisms.

Typically, when the body is threatened with bacterial or viral infection, molecules called T-cell receptors interact with protein fragments (called peptides) from the bacterium or virus, triggering the immune response. This process has been widely studied and leads to the killing of microbes and protection against severe infection.

While the immune system is known to focus on proteins from viruses and bacteria, some T-cells in the immune system (known as NKT cells) can recognise lipid-based, or fatty, molecules. As such, there is great enthusiasm for the potential of these lipid-sensing T-cells in the development of novel vaccines. This team have identified a new type of NKT cell that can specifically target lipids found in the cell walls of bacteria, including Mycobacteria.

Professor Dale Godfrey from the University of Melbourne said the discovery is significant and opens the door to a new avenue of investigation into immunity.

"The identification of a new cell type paves the way for many new studies into the unique function of these cells and how they might be harnessed for the development of new types of vaccines," he said.

Using the Australian Synchrotron, the team produced a molecular image of precisely how the new cell type's T-cell receptor recognises lipid-based molecules.

"The use of the Australian synchrotron was essential for us to undertake our study," Dr Onisha Patel from Monash University said.


'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Related biology news :

1. Worm genome offers clues to evolution of parasitism
2. Advance offers revolution in food safety testing
3. Light pollution offers new global measure of coral reef health
4. Rong Li Lab offers insight into adaptive ability of cells
5. International public-private partnership offers new paradigm for medicinal chemistry
6. UC Davis discovery offers hope for treating kidney cancer
7. New paper offers key insights into how new species emerge
8. Study offers clues to beating hearing loss
9. Fighting global warming offers growth and development opportunities
10. Brown-led team offers first look at how bats land
11. Star Trek-like technology offers noninvasive monitor for patients and athletes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest ... ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials in ...
Breaking Biology Technology: