Navigation Links
New cell therapy a promising atherosclerosis treatment
Date:3/1/2011

Researchers at Karolinska Institutet have shown in a new study on mice, that cell therapy can be used to reverse the effect of 'bad' LDL cholesterol and reduce the inflammation that leads to atherosclerosis. The new cell therapy, which is presented in the prestigious scientific journal Circulation, can open the way for new therapies for stroke and myocardial infarction if the results prove translatable to humans.

Atherosclerosis is a chronic inflammation of the blood vessels. Cholesterol is transported in the blood in particles called LDL ('bad' cholesterol) that can accumulate in the vessel walls. This triggers the body's immune system to react against LDL, which then cause inflammation in the vessels, and eventually thrombus formation. If such a thrombus forms in the coronary artery, the patient suffers a myocardial infarction; if it forms in the brain, a stroke can result.

The research group, under the direction of Professor Gran K Hansson at the Centre for Molecular Medicine, have developed a cell therapy that selectively dampens vascular inflammation induced by LDL. The therapy makes use of dendritic cells, which are characterized by a high degree of plasticity that renders them amenable to manipulation.

"With the appropriate treatment, dendritic cells can be made to inhibit rather than aggravate the inflammation around the LDL particles in the blood vessels," says Dr Andreas Hermansson, one of the researchers conducting the study. "A major advantage of this is that we can devise a treatment for vascular diseases that is highly specific."

The mouse studies now presented in Circulation have demonstrated substantial protective effects of the treatment, with a reduction of the atherosclerosis process of up around 70 percent. Last year, the researchers published results showing that antibodies recognizing the receptors that drive the immune reaction have protective effects, and now the same group is presenting a cell
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Why chemotherapy causes more infertility in women than in men
2. First-of-its-kind study shows benefits of electrical stimulation therapy for people paralyzed by spinal cord injury
3. Drug therapy shows significant benefit in treating a leading cause of childhood blindness
4. U of Alberta researcher discovers potential cancer therapy target
5. UTHealth, Athersys preclinical research on stem cell therapy for stroke presented at AHA conference
6. Photodynamic therapy against cancer
7. A loose grip provides better chemotherapy
8. Early tests find nanoshell therapy effective against brain cancer
9. New anti-HIV gene therapy makes T-cells resistant to HIV infection
10. Caffeine energizes cells, boosting virus production for gene therapy applications
11. Nanodisk gene therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
(Date:4/17/2014)... journal Current Biology on April 17 have ... The Brazilian insects, which represent four distinct but related ... first example of an animal with sex-reversed genitalia. ... different animals, Neotrogla is the only example ... Kazunori Yoshizawa from Hokkaido University in Japan. , During ...
(Date:4/17/2014)... the genetic information of DNA is used to ... numerous different functions in living organisms. Messenger RNA ... expression, by relating the genetic information of DNA ... , By examining the different types and ... at a given time, researchers can determine which ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2In sex-reversed cave insects, females have the penises 2Rapid and accurate mRNA detection in plant tissues 2
... rapidly read the genomes of entire communities of microbes, ... the jumbled reams of data. In a paper appearing ... headed by researchers at the University of Washington and ... JGI) describes a novel approach for extracting single genomes ...
... LANSING, Mich. Michigan State University scientists, armed with ... Web-based genomic database of information on crops that can ... allow us to create better biofuel crops," said C. ... leader. "Right now, about half of the biofuel crops ...
... In the event of a standoff between the United ... if elected president, know enough about the physics of ... the nation toward reduced greenhouse gas emissions, would John ... America,s carbon footprint? If not, University of California, ...
Cached Biology News:Analysis of Lake Washington microbes shows the power of metagenomic approaches 2Analysis of Lake Washington microbes shows the power of metagenomic approaches 3MSU to create genomic clearinghouse for biofuel crops 2New book tutors future presidents and public on science behind the headlines 2New book tutors future presidents and public on science behind the headlines 3New book tutors future presidents and public on science behind the headlines 4New book tutors future presidents and public on science behind the headlines 5
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... on the products of cells grown under simulated embryonic ... international license agreement with Suneva Medical, Inc. for physician-dispensed ... (CCM). , This agreement is an amendment ...
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, ... is an emerging biomedical company acquiring, developing, manufacturing, and ... , Free report download: http://equitiesiq.com/reports/alliqua/ , In ... team and Board, which launched the company’s new strategy ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... , , , , Martin Simon, ... Martin Simon, Petra Albrecht, and Helmut J. Schmidt, University of Kaiserslautern, , ... AG , , Introduction ... the surface , antigen expression of Paramecium primaurelia individual cells ...
... , , , Abstract , ... method that allows researchers to determine , the presence, structure and ... tissue or cell of interest. The basic protocol involves the , ... by amplification of the gene(s) of interest. Due to buffer incompatibilities, , ...
... , Multiporator , , , , , , , ... Protocol No. 4308 915.037 11/1999 , , , ... , Cell line , ... Transfection with , Plasmid pEGFP-N1 (in bidistilled H 2 O), , ...
Cached Biology Technology:Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf , cMaster RTplusPCR System 2Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf , cMaster RTplusPCR System 3Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf , cMaster RTplusPCR System 4Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf , cMaster RTplusPCR System 5Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf , cMaster RTplusPCR System 6Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf , cMaster RTplusPCR System 7cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 2cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 3cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 4cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 5cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 6U937 2
...
... inhibition of RNase A-type ribonucleases Product Description: ... nonhuman origin that binds noncovalently and inactivates ... B, and C). It does not interfere ... or CL3. QIAGEN RNase Inhibitor inhibits greater ...
...
... Radiochemical Purity is >95%\nNEN Radiolabeled Ligands\n\nReceptor-related ... continual availability of new radiolabeled ligands selected ... offers a wide range of products and ... including over 400 state-of-the-art radioligands. If you ...
Biology Products: