Navigation Links
New cell line should accelerate embryonic stem cell research
Date:3/14/2014

Researchers at the University of Washington have successfully created a line of human embryonic stem cells that have the ability to develop into a far broader range of tissues than most existing cell lines.

"These cells will allow us to gain a much greater understanding of normal embryonic development and have the real potential for use in developing ways to grow new tissues and organs for transplantation," said Carol Ware, a professor in the UW Department of Comparative Medicine and lead author of a paper describing the new cell line appearing in the March 10 issue of the journal Proceedings of the National Academy of Sciences.

The cells, called nave embryonic stem cells, normally appear at the earliest stages of embryonic development and so retain the ability to differentiate in all the different types of cells of the human body a capacity called pluripotency.

Researchers had been able to develop naive cells using mouse embryonic stem cells but to create naive human embryonic stem cells has required inserting a set of genes that force the cells to behave like naive cells.

While these "transgenic" cells are valuable research tools, the presence of the artificially introduced genes meant the cells will not develop as normal embryonic cells would nor could they be safely used to create tissues and organs for transplantation.

In an article, Ware and her colleagues from the UW Institute for Stem Cell and Regenerative Medicine describe how they successfully created a line of naive human embryonic stem cells without introducing an artificial set of genes.

They first took embryonic stem cells that are slightly more developed, called primed stem cells, and grew them in a medium that contained factors that switched them back or "reverse toggled" them to the naive state.

They then used the reverse toggled cells to develop a culture medium that would keep them in the naive state and create a sta
'/>"/>

Contact: Kim Blakeley
krb13@uw.edu
206-685-1323
University of Washington - Health Sciences/UW News, Community Relations & Marketing
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study: IOC should ban lead shot to help wildlife, water
2. Gastric banding patients should closely monitor nutrition following surgery
3. Ocean acidification research should increase focus on species ability to adapt
4. Bonefish spawning behavior in the Bahamas surprises researchers, should aid conservation
5. Can (and Should) Retail/Wi-Fi Analytics Help Retailers Survive in the Age of Amazon?
6. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
7. Pain management of hemiplegic shoulder pain post stroke
8. McGill discovery should save wheat farmers millions of dollars
9. Carbon farming schemes should consider multiple cobenefits
10. Risk to consumers from fungal toxins in shellfish should be monitored
11. With early, obvious benefit of a targeted cancer drug, should expensive clinical testing continue?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New cell line should accelerate embryonic stem cell research
(Date:6/17/2015)... , and HILDEN, Germany , June ... QGEN ; Frankfurt Prime Standard: QIA) today launched new Investigator ... in forensic laboratories in the United States ... to simultaneously analyze multiple key genomic markers (short tandem repeats ... Quality Sensor to evaluate the quality of DNA in ...
(Date:6/17/2015)... 17, 2015  Crossmatch™, a leading provider of ... U.are.U ® 4500 fingerprint readers have been ... Inc., a San Jose, CA ... security, improve accountability and reduce fraud at the ... identity confirmation for employee sign in and transaction ...
(Date:6/16/2015)... 2015  With the increasing number and severity of ... concern. The recent compromise of Federal employee data ... authentication within government agencies. HYPR Corp. announced ... (OTP) authenticator, has been submitted for testing and approval ... validation for tamper proofing. The proliferation ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... discovered new details about how bacteria generate energy to ... key specifics to the molecular mechanism behind the pathogen ... understanding of this pathogen, while also offering insight into ... forms required to sustain life. , As a single-cell ...
... under the microscope: the relation between biology and genetics ... the main themes of the International Workshop on the ... Bologna, May 20 to 22, with leading scientists currently ... explain their recent findings to the audience. The meeting ...
... interpret the mental state of others by looking at ... of Nottingham study has found. , In findings that ... ‘read?a stranger’s mental state based on that person’s eyes. ... at interpreting people’s mental states based on facial expressions, ...
Cached Biology News:Cholera pathogen reveals how bacteria generate energy to live 2Cholera pathogen reveals how bacteria generate energy to live 3Music genes and musical geniuses 2'The eyes have it' -- Autism research yields surprising results 2
(Date:6/30/2015)... , July 1, 2015 R-Japan Co.,Ltd. obtained ... the Safety of Regenerative Medicine from the Ministry of Health, ... June 29, 2015. The fact that R- ... facility through the auditing from Pharmaceuticals and Medical Devices Agency ... application, allows it to provide stem cell manufacturing service to ...
(Date:6/30/2015)... , June 30, 2015  NASA astronaut Kjell ... next month on his first mission to the International ... from 8 to 9 a.m. EDT Tuesday, July 7. ... in Star City, Russia . The interviews ... NASA Television highlighting his mission training. To schedule ...
(Date:6/30/2015)... ... June 30, 2015 , ... With its latest ... selectivity to achieve faster flow rates in comparison to nylon or polyethersulfone (PES). ... space to allow easy liquid flow while trapping particulates as small as 0.2 ...
(Date:6/30/2015)... DIEGO , June 30, 2015  The ... Education in Biosciences (CCE/Bio) and UC San Diego ... fermentation, to be held Aug.  12 – 14, ... ).  This three-day workshop provides an intense exposure ... industrial biotechnology, and is well-suited to biologists, process ...
Breaking Biology Technology:R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2New Nanofiber Membrane Provides Fast, Efficient Filtration 2UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2
... Approximately 89.3 Percent of Outstanding Indevus Shares Have ... Endo Pharmaceuticals (Nasdaq: ENDP ) ... York City time, on March 13, 2009, approximately ... guaranteed delivery) were validly tendered and accepted for ...
... to be Held at 9:00 a.m. Eastern Time on ... United Therapeutics Corporation (Nasdaq: UTHR ) ... with the U.S. Food and Drug Administration (FDA), the ... (NDA) for Tyvaso(TM) (inhaled treprostinil) will likely extend beyond ...
... PAREXEL experts will address the benefits of rigorous ... of the American Society for Clinical Pharmacology and Therapeutics ... in National Harbor, Maryland from March 18 - 21, ... meeting will be to help biopharmaceutical companies understand best ...
Cached Biology Technology:Endo Pharmaceuticals Extends Subsequent Offering Period for Indevus Shares Until 5:00 pm EDT on Wednesday, March 18, 2009 2Endo Pharmaceuticals Extends Subsequent Offering Period for Indevus Shares Until 5:00 pm EDT on Wednesday, March 18, 2009 3United Therapeutics Announces Probable Delay in Approval Timeline for Inhaled Treprostinil (Tyvaso) 2United Therapeutics Announces Probable Delay in Approval Timeline for Inhaled Treprostinil (Tyvaso) 3PAREXEL Experts to Address Benefits of Rigorous Early Phase Development at Annual ASCPT Meeting 2PAREXEL Experts to Address Benefits of Rigorous Early Phase Development at Annual ASCPT Meeting 3PAREXEL Experts to Address Benefits of Rigorous Early Phase Development at Annual ASCPT Meeting 4
... Continuous flow of media and other ... little lab space, The speed of each ... and flow set points, are exactly maintained. ... equipped with variable tube types, which allows ...
... Provides a fast and easy ... enriched mitochondrial fraction from mammalian tissues. ... contain inner and outer membranes. The ... functional studies and proteome profiling. Also ...
... and other fluid sources for 4 vessels ... of each individual pump is controlled electronically. ... exactly maintained. ,High-precision controlled peristaltic pumps ... which allows flow rates between 0.01 to ...
... The SearchLight® IR Mouse Cytokine Array ... assay) for the quantitative measurement of 12 ... plasma and culture supernatants. Each well of ... that capture specific cytokines in standards and ...
Biology Products: