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New cell division mechanism discovered

A novel cell division mechanism has been discovered in a microorganism that thrives in hot acid. The finding may also result in insights into key processes in human cells, and in a better understanding of the main evolutionary lineages of life on Earth. The study is published today in the online version the American National Academy of Sciences, PNAS.

The research group at the Department of Molecular Evolution at Uppsala University has identified a completely cell division machinery. The discovery was made in Sulfolobus acidocaldarius, a microorganism belonging to the third domain of life, the Archaea, which originally was isolated from a hot spring in Yellowstone national park in Wyoming, USA. Because of the extreme conditions, in which the cells grow optimally in acid at 80C, the organism is of interest for a wide range of issues.

- They represent exciting model systems in theories for how life once may have originated in hot environments on early Earth, as well as in the search for life in extreme environments on other planets, Professor Rolf Bernander explains. He is the scientist behind the study, together with colleagues Ann-Christin Linds, Erik Karlsson, Maria Lindgren and Thijs Ettema.

The researchers have identified three genes that are activated just prior to cell division. The protein products from these genes form a sharp band in the middle of the cell, between newly segregated chromosomes, and then gradually constrict the cell such that two new daughter cells are formed.

- This is the first time in decades that a novel cell division mechanism has been discovered, and the gene products display no similarity to previously known division proteins, Rolf Bernander says.

Two of the three proteins are instead related to eukaryotic so-called ESCRT- proteins, which play important roles in vesicle formation during intracellular transport processes, and which also have been implicated in virus budding, including HIV, from the cell surface. The results are, thus, important not only for an increased understanding of the cell biology of archaea and extremophiles, but also for key cellular processes in human and other higher organisms, and for issues related to the origin and evolutionary history of these processes.


Contact: Rolf Bernander
Uppsala University

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