Navigation Links
New cause found for muscle-weakening disease myasthenia gravis
Date:11/11/2013

Augusta, Ga. An antibody to a protein critical to enabling the brain to talk to muscles has been identified as a cause of myasthenia gravis, researchers report.

The finding that an antibody to LRP4 is a cause of the most common disease affecting brain-muscle interaction helps explain why as many as 10 percent of patients have classic symptoms, like drooping eyelids and generalized muscle weakness, yet their blood provides no clue of the cause, said Dr. Lin Mei, Director of the Institute of Molecular Medicine and Genetics at the Medical College of Georgia at Georgia Regents University.

"You end up with patients who have no real diagnosis," Mei said.

The finding also shows that LRP4 is important, not only to the formation of the neuromuscular junction where the brain and muscle talk but also maintaining this important connection, said Mei, corresponding author of the paper in The Journal of Clinical Investigation.

Mei and his colleagues first reported antibodies to LRP4 in the blood of myasthenia gravis patients in the Archives of Neurology in 2012. For the new study, they went back to animals to determine whether the antibodies were harmless or actually caused the disease. When they gave healthy mice LRP4 antibodies, they experienced classic symptoms of the disease along with clear evidence of degradation of the neuromuscular junction.

LRP4 antibodies are the third cause identified for the autoimmune disease, which affects about 20 out of 100,000 people, primarily women under 40 and men over age 60, according to the National Institutes of Health and Myasthenia Gravis Foundation of America, Inc.

An antibody to the acetylcholine receptor is causative in about 80 percent of patients, said Dr. Michael H. Rivner, MCG neurologist and Director of the Electrodiagnostic Medicine Laboratory, who follows about 250 patients with myasthenia gravis. Acetylcholine is a chemical released by neurons w
'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Will a genetic mutation cause trouble? Ask Spliceman
2. Record-breaking grant: New research project to investigate the causes of mental disorders
3. BPA could affect reproductive capabilities, cause infection of the uterus
4. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
5. A new gene thought to be the cause in early-onset forms of Alzheimers disease
6. Long-term research reveals causes and consequences of environmental change
7. Changes in brains blood flow could cause brain freeze
8. Yeast cell reaction to Zoloft suggests alternative cause, drug target for depression
9. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
10. Double the pain: RUB biologists find the cause of pain in the treatment of fair skin cancer
11. Gene mutations cause massive brain asymmetry
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New cause found for muscle-weakening disease myasthenia gravis
(Date:7/24/2014)... in German . ... they are a common sight on the roads of the ... the list of new vehicle registrations for the second time. ... where electric vehicles claim only a small portion of the ... Germany, only a mere 8000 are electric powered. The main ...
(Date:7/24/2014)... inside your gut that has gone undetected by scientists ... San Diego State University has found that more than ... described virus, named crAssphage, which infects one of the ... This phylum of bacteria is thought to be connected ... appears today in Nature Communications ., Robert A. ...
(Date:7/23/2014)... Protection Agency (EPA) today announced that environmental health ... Amherst School of Public Health and Health Sciences ... Achieve Results (STAR) grant to measure indoor air ... in subarctic North America to determine possible health ... culturally-relevant recommendations for mitigation. , Peltier, who will ...
Breaking Biology News(10 mins):Nano-supercapacitors for electric cars 2Nano-supercapacitors for electric cars 3Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3Studying impacts of indoor air pollution on tribal communities 2Studying impacts of indoor air pollution on tribal communities 3
... the logic of inheritance in his monastery garden with no ... House. So why couldn,t Darwin have done it too? A ... influences and research focus gave him a viewpoint that prevented ... even in his own work. Darwin,s commitment to ...
... just off the east coast of Australia, picturesque North ... some of the inhabitants of the island,s creeks and ... territorial creatures, explains ecologist Robbie Wilson of the University ... one another, they size each other up in a ...
... HAVEN, FLFresh strawberries. Just the mention of this iconic ... of shortcake, fruity drinks and sweet desserts. Researchers interested ... that "sensory quality" of strawberries, a strong influence on ... of sweetness, aroma, texture, and appearance. The goals ...
Cached Biology News:Why didn't Darwin discover Mendel's laws? 2Crafty Australian crayfish cheat 2Analysis of fresh strawberries reveals consumer preferences 2
(Date:7/24/2014)... balances – 4 steps – One Recommendation: the web-based ... narrows down the mass of product choices to a ... , First, select the working environment, then enter the ... define the accuracy – it’s really that simple. Specifying ... to models that fit best with the customer’s industry ...
(Date:7/24/2014)... 2014 Draper University, a top ... to announce that for 6 weeks this summer, ... converge on the Draper University campus in the ... program focused on entrepreneurship, building real-world skills, and ... running its sixth cohort, continues to refresh its ...
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/24/2014)... Diego, CA (PRWEB) July 24, 2014 ... the reporting of molecular diagnostic test results. It ... capabilities necessary for the validation and reporting of ... oncology. Molecular diagnostics is a rapidly growing area ... infectious disease, genetic predisposition, cancer, and companion diagnostics ...
Breaking Biology Technology:Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2
... BRUNSWICK, N.J., Feb. 18 Senesco Technologies, Inc. ... financial results for the three months ended December 31, 2008. ... 2008 was $1,624,341, or $0.09 per share, compared with a ... three month period ended December 31, 2007. This increase ...
... a,biotechnology company focused on novel therapeutic and preventative,approaches ... of an EUR18M ($23M) Series B financing round ... operational and clinical level. Novartis Venture Fund,Fountain Healthcare ... all participated in the funding. , ...
... more light than heat. Engineers working in optical technologies ... with much greater speed than do electrical signals, says ... Bethlehem, Pa. If they are guided with sufficient precision ... can bring about applications in spectroscopy, sensing and medical ...
Cached Biology Technology:Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 2Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 3Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 4Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 5Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 6Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 7Opsona Therapeutics Closes EUR18M Funding 2Opsona Therapeutics Closes EUR18M Funding 3Opsona Therapeutics Closes EUR18M Funding 4Engineers tune a nanoscale grating structure to trap and release a variety of light waves 2Engineers tune a nanoscale grating structure to trap and release a variety of light waves 3
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks...
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
... technology incorporating the sophisticated DirectDrive architecture ... new Varian NMR System is undeniably ... ,The Varian NMR System features parallel ... channel, providing pulse sequence programming power ...
Biology Products: