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New cancer gene discovered
Date:10/13/2009

ly recently that we've had access to the tools needed to prove it," says Stenman.

The research group has also looked at the mechanism behind the transformation of the normal MYB gene into a cancer gene. Genes can be compared to blueprints for proteins. Carefully controlled regulating systems then determine when and how much of each protein is formed. One such regulating system, discovered recently, is microRNA, which can turn genes on and off. When this cancer gene forms, this important control system is put out of action, leading to activation of the gene and massive overproduction of an abnormal MYB protein with carcinogenic properties.

"This is an important discovery, because it's a new mechanism which I think will turn out to be quite common in a variety of human cancers," says Stenman.


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Contact: Professor Goran Stenman
goran.stenman@llcr.med.gu.se
46-313-422-922
University of Gothenburg
Source:Eurekalert

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