Navigation Links
New cancer-fighting strategy focuses on signaling molecules
Date:2/24/2010

essels to feed nutrients to growing tumors and to advance progression to malignant cancer.

Most tumors are rife with activated immune cells, says Coussens, but their role in the development of cancer has been largely overlooked.

The findings may lead to more successful treatment of certain solid tumors by combining chemotherapy with drugs that can thwart cancer-promoting activities of the immune system, according to Coussens. For instance, the drug Rituxan has relatively few side effects, she adds.

As a result of the molecular discovery, Coussens is collaborating with pharmaceutical industry experts to explore new therapeutic strategies. Preclinical testing of the combination approach is underway involving therapies similar to Rituxan and chemotherapy, and initial results "look promising,'' says Coussens.

At UCSF, the Coussens lab focuses on the role of inflammatory cells and leukocyte proteases as critical regulators of skin, lung and breast cancer development. During the early development of cancer, many physiological processes occur in the vicinity of young tumor cells that are similar to processes that occur during embryonic development and to healing of wounds in adult tissue.

By studying mouse models of skin, lung and breast cancer development, the Coussens lab is identifying important molecules involved in regulating tumor-associated inflammation, angiogenesis, and cancer development. Identification of these important regulatory mechanisms reveals drug-targets that can then be used to design novel therapeutic strategies for treating cancer development in humans.

Biochemical and cellular studies during the past decade have shown that inflammation can promote the development of cancer. In addition, certain chronic inflammatory conditions, such as Crohn's disease, pancreatitis, prostatitis, asbestosis and Barrett's esophagus, are associated with an elevated cancer risk.

Discoveries over the last
'/>"/>

Contact: Elizabeth Fernandez
efernandez@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U-Iowa improves delivery of cancer-fighting molecules
2. FSU researcher using computers to hone cancer-fighting strategies
3. Researchers uncover key trigger for potent cancer-fighting marine product
4. Queens researchers propose rethinking renewable energy strategy
5. H1N1 influenza adopted novel strategy to move from birds to humans
6. Skunks strategy not just black and white
7. New strategy for mending broken hearts?
8. Strategy outlined for growing bioenergy while protecting wildlife
9. IEEE-USA President endorses national innovation strategy
10. Science Coalition commends Presidents strategy for innovation
11. New strategy for inhibiting virus replication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... detection cartridge developed at Sandia National Laboratories and recently ... faster and cheaper. , Bacillus anthracis , ... soils all over the world and can cause serious, ... The bacteria can survive in harsh conditions for decades. ... occur through skin contact, inhalation of spores or eating ...
(Date:4/17/2014)... Calif. One day about eight years ago, ... California, Riverside, and her father were on a field trip ... upon an orchid they had never seen before. , Unable ... on orchids. The orchid turned out to be an ... Lophiaris silverarum . , "Lophiaris" is the genus name, ...
(Date:4/17/2014)... France have hit on a novel method to ... correct and most effective treatment possible., Kidney stones ... and developing world. If left untreated, apart from ... failure and other complications. In many patients treated ... a more effective pathological approach to diagnosis and ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
... a common feature of prion disease-affected human, mouse, and ... Neena Singh and colleagues at Case Western Reserve University ... findings, published March 13 in the open-access journal ... of neurotoxicity in prion disorders, and novel avenues for ...
... Kansas State,University, with collaboration from Epitopix LLC, have ... E. coli O157 in beef cattle. ... the post-harvest food safety,aspect, whether it,s E. ... College of Veterinary Medicine. Thomson is the Jones,Professor ...
... German . The Aarhus University ... between the many conference participants and according to ... Kyoto was very successful in doing so: "I am ... will undoubtedly contribute significantly to the future climate debate ...
Cached Biology News:Iron is involved in prion disease-associated neuronal demise 2K-State researchers help Epitopix license the United States' first E. coli O157 vaccine for cattle 2Seven recommendations from Aarhus to COP15 2Seven recommendations from Aarhus to COP15 3
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... January 14, 2014 Histogen, Inc., a ... of cells grown under simulated embryonic conditions, today announced ... with Suneva Medical, Inc. for physician-dispensed aesthetic products containing ... , This agreement is an amendment to the existing ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... measurement and control provider, is pleased to release ... family of mass flow products designed to be ... on a standard 1.125-inch wide platform with a ... B-Series provides a compact flow measurement and control ...
... announced it has been awarded a 5-year, $17.8 million ... (USAID) to lead a team of organizations in improving ... a member of the North American Free Trade Agreement ... States. USAID programs support Mexican efforts to strengthen ...
... Department in State of Qatar to Introduce State-of-the-Art ... One of the leading cancer centers in the ... from Varian Medical Systems (NYSE: VAR ... precise treatments. Al Amal Hospital in Doha, Qatar, ...
Cached Biology Technology:Brooks Instrument's New Mass Flow Controller Series Is Immune to Pressure and Temperature Fluctuations 2Brooks Instrument's New Mass Flow Controller Series Is Immune to Pressure and Temperature Fluctuations 3USAID Selects Abt Associates to Lead Team in Strengthening Mexico Private Sector Competitiveness 2Leading Middle East Cancer Hospital Acquires Advanced Radiotherapy Capability from Varian Medical Systems 2Leading Middle East Cancer Hospital Acquires Advanced Radiotherapy Capability from Varian Medical Systems 3
... trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl ... latanoprost-related isomer containing both a double ... (β) hydroxyl group at C-15. Similar ... ester is a potential impurity in ...
... new product number, created to easily match ... yet, please order under the old Sigma-Aldrich ... assistance. Feature: tissue-culture treated yes ... cm 2 D H 60 ...
... bind specifically to Fc regions of many ... conjugates are commonly used as affinity adsorbents ... from serum, hybridoma ascites fluids, tissue culture ... are also commonly used to capture immune ...
... min) assay can detect H2O2 or peroxidase ... H2O2 oxidizes ADHP in a 1:1 stoichiometry ... at 530-571 nm, emission at 590-600 nm). ... a one-step, homogeneous, no wash assay system. ...
Biology Products: