Navigation Links
New cancer-fighting strategy focuses on signaling molecules
Date:2/24/2010

Cancer researchers studying the immune system have identified a previously unrecognized set of targets and biomarkers to battle solid tumors.

The findings center on discovery of signaling molecules that are major players in a biochemical mechanism linking certain actions of B cells to solid tumor growth. The most notable implication of the study is that a drug in use for more than decade to treat non-Hodgkin's lymphoma, which is a cancer of the B cells, might be effective against other solid tumors, says lead author Lisa Coussens, PhD, of the UCSF Helen Diller Family Comprehensive Cancer Center.

"This is paradigm shifting," emphasizes Coussens, who is a pioneer in studying the role of molecular regulation in cellular inflammation that is linked to development of cancer. "The discoveries open up our thinking to many new signaling molecules as potential therapeutic targets.''

The research is published online and in print by the scientific journal "Cancer Cell" (vol.17, issue 2, http://www.cell.com/cancer-cell/current).

"These are very significant findings because they suggest that Rituxan, a drug that we already are familiar with, could have very broad clinical implications in the treatment of some solid tumors,'' says Coussens, who also is a professor in the UCSF Department of Pathology and co-director of the Mouse Pathology Core and Program in Cancer, Immunity and Microenvironment.

The researchers found that a class of antibodies known as immunoglobulin G and the receptors to which they bind play a key role in the link between B cells and solid tumor growth. Called FcRgamma, these receptors are found on cells of the innate immune system (including mast cells, macrophages, and dendritic cells). The activation of FcRgamma plays a part in recruiting circulating immune cells to neoplastic (abnormal) tissue, which in turn enhances development of new blood v
'/>"/>

Contact: Elizabeth Fernandez
efernandez@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U-Iowa improves delivery of cancer-fighting molecules
2. FSU researcher using computers to hone cancer-fighting strategies
3. Researchers uncover key trigger for potent cancer-fighting marine product
4. Queens researchers propose rethinking renewable energy strategy
5. H1N1 influenza adopted novel strategy to move from birds to humans
6. Skunks strategy not just black and white
7. New strategy for mending broken hearts?
8. Strategy outlined for growing bioenergy while protecting wildlife
9. IEEE-USA President endorses national innovation strategy
10. Science Coalition commends Presidents strategy for innovation
11. New strategy for inhibiting virus replication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) ... Global Watermarking and Fingerprinting Markets" report to ... This insight provides an overview ... markets. Watermarking aims to control and monitor piracy ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced ... - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of AuthenTec ... with the iPhone 5S. It is currently the only ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... as David Attenborough and directors of some of the ... Leopold, a University of Washington professor emeritus of botany, ... Prize carries a cash award of 40 million yen, ... team each year, according information from Japan,s Expo ,90 ...
... Troy, NY In the spring, later sunset and ... researchers at Rensselaer Polytechnic Institute,s Lighting Research Center (LRC). ... in the spring delays the onset of nocturnal melatonin, ... nighttime," explains Mariana Figueiro, Ph.D., associate professor. "This ...
... team of scientists has been exploring Moreton Bay, close to Brisbane, ... Reef at risk of extermination under climate change. In a ... survive and flourish in the Bay, which lies well to the ... the past 7000 years. Corals only cover about 1 per ...
Cached Biology News:University of Washington professor's lifetime efforts receive international recognition 2University of Washington professor's lifetime efforts receive international recognition 3Exposure to early evening sunlight in spring creates teenage night owls 2Exposure to early evening sunlight in spring creates teenage night owls 3Scientists test Moreton Bay as coral 'lifeboat' 2Scientists test Moreton Bay as coral 'lifeboat' 3
(Date:1/22/2015)... 22, 2015 Crystal Diagnostics (CDx) Xpress System, ... has received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing ... collectively referred to as STEC or the “Big-6”) as well ... unit (cfu) per 325 g of raw ground beef and ...
(Date:1/22/2015)... Geneva, Switzerland (PRWEB) January 22, 2015 ... for characterized mammalian Research Cell Banks (RCBs) used for ... generated Research Cell Banks will include Next-Generation Sequencing ... cell’s genetic architecture de-risks biologic manufacturing by ensuring the ...
(Date:1/22/2015)... 2015   GenoSpace , a precision medicine software company that ... broad use of genomic, imaging and other biomedical data in ... Michelle Munson , CEO of Aspera, an IBM Company, to ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to ...
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... 2011 Students, faculty and supporters of The University ... the 234,000-square-foot, state-of-the-art Engineering Research Building with a March ... http://photos.prnewswire.com/prnh/20110301/DC56976 ) The landmark center ... is shared by College of Engineering and ...
... Advanced Health Media (AHM), the leading supplier of technology ... announced that Greg Miller, AHM,s Executive Vice President and ... Council (NJTC) as the recipient of the 2011 CIO ... Year award recognizes Information Technology (IT) executives, innovation and ...
... March 1, 2011 BioNeutral Group, Inc. (OTC Bulletin ... technology-based company, today announced that its wholly-owned subsidiary, BioNeutral ... Development Finance Authority (KEDFA) to receive up to $280,000 ... At a February 24 meeting, six companies, including ...
Cached Biology Technology:UT Arlington Honors Collaborative Research During March 4 Engineering Research Building Dedication 2UT Arlington Honors Collaborative Research During March 4 Engineering Research Building Dedication 3Greg Miller of Advanced Health Media Named New Jersey Technology Council CIO of the Year 2BioNeutral Group to Receive Economic Development Incentives 2BioNeutral Group to Receive Economic Development Incentives 3
Canine Aortic Smooth Muscle Cells (CnAOSMC) (>500,000 cells)...
... cell lines in combination with the corresponding ... Kits are only functional in combination with ... be transfected with this kit. The corresponding ... in percent (Efficiency [%] / viability [%]). ...
... Human Pathogenic Viruses The ... (NCPV) preserves well characterised, authenticated ... secure facility, and NCPV is ... or nucleic acids derived from ...
B-FABP (FL-132)...
Biology Products: