Navigation Links
New cancer drug delivery system is effective and reversible

CHAMPAIGN, Ill. For cancer drug developers, finding an agent that kills tumor cells is only part of the equation. The drug must also spare healthy cells, and ideally its effects will be reversible, to cut short any potentially dangerous side effects.

University of Illinois researchers report that they have assembled a new cancer drug delivery system that, in cell culture, achieves all of the above. The findings appear this month in the journal Angewandte Chemie.

The team began with the knowledge that small, membrane-bound compartments, called liposomes, are useful as drug-delivery vehicles. When linked to molecules that target receptors on cancer cells, liposomes can enter and dump their cancer-killing contents into those cells.

Scientists have spent more than a decade trying to direct liposomes to specific cancer cells, with limited success. A common approach involves attaching an antibody to the liposome membrane. Ideally the antibody will bind to a cancer cell receptor so that it can deliver the liposome and the cancer drug into the cell.

Developing such antibodies is costly and time-consuming, however, and the process of attaching them to liposomes is difficult to control. Antibodies spur an immune response, requiring extra steps to create a useable therapeutic agent, and the ability of antibody-conjugated liposomes to bind to cancer cells can be inconsistent.

Some small molecules, such folate, a vitamin, also work as cancer cell targeting agents, but those now in use are not as good as antibodies at binding to cancer cells.

To solve the cell-targeting problem, the U. of I. team turned its attention to small molecules called aptamers.

"Aptamers are short strands of DNA or RNA; they are highly efficient binders, and are very easy to make, label and manipulate," said Zehui Cao, a postdoctoral researcher in the laboratory of chemistry professor Yi Lu, who led the study. Materials s

Contact: Diana Yates
University of Illinois at Urbana-Champaign

Page: 1 2 3

Related biology news :

1. Protein handlers should be effective treatment target for cancer and Alzheimers
2. Moving to the US increases cancer risk for Hispanics
3. Women often opt to surgically remove their breasts, ovaries to reduce cancer risk
4. Pitt researchers find promising candidate protein for cancer prevention vaccines
5. The way you eat may affect your risk for breast cancer
6. Stem cell daughters lead to breast cancer
7. Study links virus to some cases of common skin cancer
8. A crystal ball for brain cancer?
9. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
10. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
11. Cancers distinctive pattern of gene expression could aid early screening and prevention
Post Your Comments:
Related Image:
New cancer drug delivery system is effective and reversible
(Date:8/21/2014)... BOSTON -- Nine researchers from Beth Israel ... included in "The World,s Most Influential Scientific Minds ... from Thomson Reuters ScienceWatch, a web resource for science ... scientists recognized as among the most influential "are performing ... to the advancement of their science," according to a ...
(Date:8/21/2014)... window? It consists of radiations in the 3.3 to ... water in biological tissues. New theoretical findings show that ... water window. These could be the basis of an ... biological samples or to be used in high-precision spectroscopy. ... needed to efficiently generate the harmonic radiationswhich are multiples ...
(Date:8/21/2014)... feeding tube connectors, designed by an international standards process, ... , According to an invited review published in the ... ( NCP ), the official journal of the American ... connectors will greatly reduce the occurrence of misconnection that ... Small-bore connectors, which are used to join medical devices, ...
Breaking Biology News(10 mins):BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2
... A new study by top global fisheries experts presents ... The analysis of 61 species of "scombrids," which include ... include swordfish and marlins, classified seven as threatened with ... Red List of Threatened Species. University of Miami ...
... The Northwest Forest Plan enacted in 1993 was designed ... northern spotted owl, but researchers conclude in a new study ... carbon sequestration on public lands. When forest harvest levels ... after passage of this act, they became a significant carbon ...
... NEW YORK (July 22, 2011)A genetic study ... that the big-horned animals travel extensively across the ... to Wildlife Conservation Society researchers with the support ... Using a non-invasive technique that extracts DNA from ...
Cached Biology News:Double jeopardy: Tuna and billfish 2Northwest Forest Plan has unintended benefit - carbon sequestration 2World's largest sheep an international traveler 2World's largest sheep an international traveler 3
(Date:8/22/2014)... 2014 “Our nation's healthcare system ... national disgrace. Furthermore, every governmental and professional entity ... deplorable state of unorganized dysfunction shares in that ... merely serve as a device to use in ... failure(s) that have accumulated through the years leading ...
(Date:8/21/2014)... research team including DESY scientists has observed tiny quantum ... reports in the journal Science that the ... the nanodroplets. It is the first time that the ... samples of what is known as superfluid helium, have ... best expectations," says Andrey Vilesov of the University of ...
(Date:8/21/2014)... COLD SPRING, N.Y. , Aug. 21, 2014 ... today the launch of their Nutraceutical "TELO-20 for ... first and only Telomere-lengthening supplement in the world ... the ends of every chromosome in the body. ... the world,s leading experts in Telomere Science and ...
(Date:8/21/2014)... , Aug. 21, 2014 ... Immune Pharmaceuticals Inc., a biotechnology company, on its ... Immune previously traded on OTCQX®, the best marketplace ... OTC Markets Group. Logo - ... on the successful execution of its growth strategy ...
Breaking Biology Technology:5 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... part of its ongoing efforts to improve the quality ... diagnosed with scoliosis, Axial Biotech, Inc., a company revolutionizing ... today announced that it has signed a multi-year agreement ... The agreement focuses on providing access to ...
... 2011 ,   Amsterdam ... human gene therapy, today announced the appointment of,Dr. Carlos ... AMT more than 25 years of pharmaceutical industry experience,most ... approvals at the European Medicines Agency (EMA),and U.S. Food ...
... Nottingham and using nanotechnology 100,000 times smaller than the thickness ... the vast energy of the Sun to produce clean fuel. ... Society,s annual Summer Science Exhibition which opens ,today [5 July ... have already found a way to produce hydrogen from water. ...
Cached Biology Technology:Axial Biotech Signs Agreement With Shriners Hospital for Children 2Axial Biotech Signs Agreement With Shriners Hospital for Children 3Amsterdam Molecular Therapeutics Appoints Dr. Carlos R. Camozzi as Chief Medical Officer 2Amsterdam Molecular Therapeutics Appoints Dr. Carlos R. Camozzi as Chief Medical Officer 3Putting sunshine in the tank 2
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
Hamartin/TSC1 (1B2) Mouse mAb Ship: Hot Store: -20 C...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: