"The hope of this new breed of 'gene hunters' was that cracking the life code of Plasmodium falciparum would reveal the novel biochemical Achilles' heel of the parasite and lead to the development of antimalarial drugs and vaccines," Sherman said.
The grand promise of the Plasmodium falciparum Genome Project, he added, was that a more complete understanding of the malaria parasite's genes would allow a better understanding of the regulation of the parasite's complex life cycle in human red blood and liver cells, identify those genes the parasite uses to thwart the host immune response, and explain the manner by which it is possible for the parasite to evade cure after drug treatments.
To write the 372-page book, Sherman combed through the literature on malaria-related topics with a critical eye. He then turned all the information into a digestible form for readers interested in science.
Sherman received his master's and doctoral degrees from Northwestern University, Ill., where his lifelong research on the biochemistry of malaria parasites began. He joined UC Riverside in 1962 and retired in 2006. During his tenure, he served as chair of the Department of Biology (1973-1978); dean of the College of Natural and Agricultural Sciences (1981-1988); acting executive vice chancellor (1993-1994); and chair of the Academic Senate (1997-2004).
The author or coauthor of more than 150 scholarly papers and 7 books, Sherman also has edited two books on malaria. His book,
"The Power of Plagues" (American Society for Microbiology Press, 2006), examined the interrelationship between plagues and culture. His book "Twelve Diseases That Changed Our World" (American Society for Microbiology Press, 2007) focused on a dozen diseases that greatly influenced societ
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University of California - Riverside