Navigation Links
New book reviews research on p53 -- the 'guardian of the genome' -- and its relatives
Date:6/23/2010

COLD SPRING HARBOR, N.Y. (June 23, 2010) -- The p53 tumor suppressor gene, the "guardian of the genome," protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of proteins that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

A new book from Cold Spring Harbor Laboratory Press, The p53 Family, provides a comprehensive review of the functions of the p53 family. It was edited by Arnold Levine and David Lane, who independently discovered p53 about 30 years ago.

"We hope that by bringing together a unique gathering of experts this volume will provide a great introduction to the field for newcomers to the p53 family and a starting off point for vigorous debate among the converted," write Levine and Lane in the preface to the book. "The many unknowns in this system that are detailed and discussed in this volume provide us all with inspiration for future work."

In 23 chapters, the contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line.

The p53 Family also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1

Related biology news :

1. New book reviews the structure and function of cell junctions
2. EPA reviews Univ. of Michigan dioxin study
3. Reviews of microbial gene language published in special issue of Trends in Microbiology
4. Biophysical Reviews makes debut in 2009
5. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
6. Researchers create self-assembling nanodevices that move and change shape on demand
7. UCI researchers develop worlds first plastic antibodies
8. Rice yields researched to tackle food security issues
9. Freely available data supporting next generation of human genetic research
10. NYU Langone Medical Center receives $5.4 million NYSTEM grant for stem cell research
11. Research on stem cells wins first prize for Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book reviews research on p53 -- the 'guardian of the genome' -- and its relatives
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft System ... over the next decade to reach approximately $14.21 billion by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/22/2017)... 2017 Optimove , provider of ... such as 1-800-Flowers and AdoreMe, today announced two ... Replenishment. Using Optimove,s machine learning algorithms, these features ... replenishment recommendations to their customers based not just ... customer intent drawn from a complex web of ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... Recent studies show ... Many treatments for specific cancers, such as breast, prostate, or lung, target vital ... deprivation therapy for advanced prostate cancer. , This therapy limits the production ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... system, announced it has secured $2M in funding from an impressive group of ... Innovations, and SVG Thrive Fund. With this investment, 3Bar is broadening availability of ...
(Date:8/16/2017)... edition of the Inc. 5000 features a now-familiar name: BioPoint ( http://biopointinc.com/ ... list for the third year in a row. Now in its 36th ... a set of quantitative metrics. In addition, BioPoint was also named to ... Bay State . ... ...
(Date:8/15/2017)... Aug. 15, 2017 After spending the past two years ... crowdsourced data collection, GeneFo now offers this platform to healthcare stakeholders ... amplifying support, adherence, and data collection vis a vis their members, ... the successful launch of this offer. ... GeneFo ...
Breaking Biology Technology: