Navigation Links
New book presents methods to poke and prod individual molecules
Date:11/20/2007

COLD SPRING HARBOR, N.Y. Single-molecule biologythe revolutionary field that deals with the study of individual macromoleculesis undergoing rapid growth. Tremendous technical advances have made it possible to probe molecules one by one, and to produce dynamic images as they twist, twirl, wobble, and unfold. These high-tech methods are the focus of a new book that was just released by Cold Spring Harbor Laboratory Press (www.cshlpress.com).

Single-Molecule Techniques: A Laboratory Manual is the first to take researchers who know nothing about single-molecule analyses to the point where they can successfully design and execute appropriate experiments. It is geared toward research scientists, post-docs, and graduate students in structural and molecular biology, biochemistry, and biophysics, as well as all who are interested in observing, manipulating, and elucidating the molecular mechanisms and discrete properties of macromolecules.

In order to examine biological phenomena on a molecular level, scientists formerly needed to test an entire population of molecules to capture an average of whats happening. But using single-molecule techniques, scientists are now able to examine macromolecules in singuloone by oneand obtain astonishingly clear views of discrete molecular and cellular events. These high-tech methods have primarily been the domain of biophysicists, but recently, the field of single-molecule biology has burgeoned into a multidisciplinary activity.

Now it seems appropriate that the techniques of single molecules be extended to other users, not just to the experts, write the editors, Drs. Paul Selvin and Taekjip Ha, in the preface to the book. Selvin and Ha are well-respected pioneers in the field of single-molecule biology and active scientists at the University of Illinois, Urbana-Champaign. We hope to reach a wide audience, and for that, we aim to present a clear and accessible discourse, they continue. Hopefully, this will further enhance the field.

Step-by-step protocols cover a range of methods, and are broadly divided into two categories: (1) fluorescence-based imaging methods, which include both in vivo and in vitro techniques, and (2) force-based methods, such as atomic force microscopy, optical and magnetic tweezers, and nanopores. Results from these experiments provide valuable information about the structural properties, mechanics, and sub-cellular locations of macromolecules, often with measurements at nano- and pico-unit resolution.

Single Molecule Techniques also includes substantial background information on each technique to guide researchers through each step of designing and executing experiments that yield informative results.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory  
Source:Eurekalert

Related biology news :

1. Frontiers in Optics presents scientific advancements
2. New book presents successful strategies for probing genetic variation
3. NARSAD presents 2007 prizes for outstanding achievement in neuroscience and psychiatric research
4. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
5. Contraception: progress brings hope for new methods for men
6. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
7. First individual genome sequence published
8. Clemson scientists shed light on molecules in living cells
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Curry-derived molecules might be too spicy for colorectal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book presents methods to poke and prod individual molecules
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, Inc. ... therapeutics focused on the gut microbiome, today announced ... 25,000,000 shares of its common stock and warrants ... at a price to the public of $1.00 ... Synthetic Biologics from the offering, excluding the proceeds, ...
(Date:11/14/2016)... Inc. ("xG" or the "Company") (Nasdaq: XGTI, XGTIW), a ... challenging operating environments, announced its results for the third ... conference call to discuss these results on November 15, ... Key Recent Accomplishments The ... Vislink Communication Systems. The purchase is expected to close ...
(Date:6/27/2016)... DUBLIN , June 27, 2016 Research ... in North America 2016-2020" report to their offering. ... North America to grow at a CAGR ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... KING OF PRUSSIA, PA (PRWEB) , ... December 01, 2016 , ... ... clinical research is through industry-wide collaboration, standardization and a beautiful technology experience. All three ... which convened more than 100 clinical trial leaders from over 40 sponsor, CRO and ...
(Date:12/2/2016)... Dec. 1, 2016   SurePure, Inc. (OTCQB: ... that the Company has concluded an agreement with Tamarack ... a 90-day period to acquire units of the Company,s ... USD 3.7 million.  Concurrently with the ... under which Tamarack will seek regulatory approvals in ...
(Date:11/30/2016)... announced the appointment of Joshua F. Coleman , M.D., ... Coleman will oversee clinical content development and curation of scientific ... suite empowers molecular pathologists with a seamless workflow for the ... quality control through reporting. ... , , Prior ...
(Date:11/30/2016)... Nov. 30, 2016  The Allen Institute for ... the first publicly available collection of gene edited, ... target key cellular structures with unprecedented clarity. Distributed ... powerful tools are a crucial first step toward ... understand what makes human cells healthy and what ...
Breaking Biology Technology: