Navigation Links
New book presents methods to poke and prod individual molecules
Date:11/20/2007

COLD SPRING HARBOR, N.Y. Single-molecule biologythe revolutionary field that deals with the study of individual macromoleculesis undergoing rapid growth. Tremendous technical advances have made it possible to probe molecules one by one, and to produce dynamic images as they twist, twirl, wobble, and unfold. These high-tech methods are the focus of a new book that was just released by Cold Spring Harbor Laboratory Press (www.cshlpress.com).

Single-Molecule Techniques: A Laboratory Manual is the first to take researchers who know nothing about single-molecule analyses to the point where they can successfully design and execute appropriate experiments. It is geared toward research scientists, post-docs, and graduate students in structural and molecular biology, biochemistry, and biophysics, as well as all who are interested in observing, manipulating, and elucidating the molecular mechanisms and discrete properties of macromolecules.

In order to examine biological phenomena on a molecular level, scientists formerly needed to test an entire population of molecules to capture an average of whats happening. But using single-molecule techniques, scientists are now able to examine macromolecules in singuloone by oneand obtain astonishingly clear views of discrete molecular and cellular events. These high-tech methods have primarily been the domain of biophysicists, but recently, the field of single-molecule biology has burgeoned into a multidisciplinary activity.

Now it seems appropriate that the techniques of single molecules be extended to other users, not just to the experts, write the editors, Drs. Paul Selvin and Taekjip Ha, in the preface to the book. Selvin and Ha are well-respected pioneers in the field of single-molecule biology and active scientists at the University of Illinois, Urbana-Champaign. We hope to reach a wide audience, and for that, we aim to present a clear and accessible discourse, they continue. Hopefully, this will further enhance the field.

Step-by-step protocols cover a range of methods, and are broadly divided into two categories: (1) fluorescence-based imaging methods, which include both in vivo and in vitro techniques, and (2) force-based methods, such as atomic force microscopy, optical and magnetic tweezers, and nanopores. Results from these experiments provide valuable information about the structural properties, mechanics, and sub-cellular locations of macromolecules, often with measurements at nano- and pico-unit resolution.

Single Molecule Techniques also includes substantial background information on each technique to guide researchers through each step of designing and executing experiments that yield informative results.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory  
Source:Eurekalert

Related biology news :

1. Frontiers in Optics presents scientific advancements
2. New book presents successful strategies for probing genetic variation
3. NARSAD presents 2007 prizes for outstanding achievement in neuroscience and psychiatric research
4. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
5. Contraception: progress brings hope for new methods for men
6. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
7. First individual genome sequence published
8. Clemson scientists shed light on molecules in living cells
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Curry-derived molecules might be too spicy for colorectal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book presents methods to poke and prod individual molecules
(Date:3/17/2016)... 2016 ABI Research, the leader in ... biometrics market will reach more than $30 billion ... 2015. Consumer electronics, particularly smartphones, continue to boost ... to reach two billion shipments by 2021 at ... , Research Analyst at ABI Research. "Surveillance is ...
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... http://www.apimages.com ) - --> - Renvoi : ... - --> --> ... solutions biométriques, fournit de nouveaux lecteurs d,empreintes digitales ... LF10 de DERMALOG sera utilisé pour produire des ...
(Date:3/10/2016)... BLUE BELL, Pa. , March 10, 2016   ... U.S. Customs and Border Protection (CBP) is testing ... in San Diego to help identify ... United States . The test, designed to help determine ... outdoor, pedestrian environment, began in February and will run until ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... Kansas City, Missouri (PRWEB) , ... May 04, 2016 , ... ... President of Professional and Agricultural Sales. , Doug began his career at PBI-Gordon ... has since served in a wide variety of roles, ranging from customer service to ...
(Date:5/3/2016)... ... ... In a list published by the Boston Business Journal, iLab Solutions ... small percentage of the state's 615,000+ small businesses. The list examined companies based in ... 2012 to 2015. , As this award comes on the heels of ...
(Date:5/3/2016)... New York, NY (PRWEB) , ... May 03, ... ... and NeuroTech NYC , the sensor and data driven conferences, will take ... include:, UnitedHealth's Vidya Raman-Tangella on incorporating technology -- ...
(Date:5/3/2016)... Los Angeles, Calif (PRWEB) , ... May 03, ... ... network of industry leading fertility clinics and IVF laboratories. A contingency of reproductive ... Fertility™ to treat men and women experiencing infertility and to help them build ...
Breaking Biology Technology: