Navigation Links
New book on protein homeostasis from Cold Spring Harbor Laboratory Press
Date:10/7/2011

Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause such mechanisms to become dysfunctional or overloaded, resulting in the accumulation and aggregation of misfolded proteins a feature of numerous neurodegenerative conditions.

Written and edited by experts in the field, Protein Homeostasis covers the entire spectrum of protein homeostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry. The contributors examine the physical biochemistry of protein folding and the roles of the various cellular compartments in protein quality control, as well as approaches for ameliorating protein misfolding and aggregation diseases.

Including discussions of specific disorders such as Alzheimer's disease, Huntington's disease, and prion diseases, this book is an essential reference for not only molecular and cellular biologists but also medical scientists wishing to understand the pathological consequences of and potential therapies for protein homeostasis deficiencies in common human diseases.


'/>"/>

Contact: Elizabeth Powers
powerse@cshl.edu
516-422-4101
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1

Related biology news :

1. High-performance simulation, neutrons uncover 3 classes of protein motion
2. Scientists discover the proteins that control development of varicose veins
3. Pitt team identifies key protein causing excess liver production of glucose in diabetes
4. Compound kills highly contagious flu strain by activating antiviral protein
5. Protein switches could turn cancer cells into tiny chemotherapy factories
6. Cancer proteins surprising role as memory regulator
7. From protein to planes and pigskin
8. Abnormal activation of a protein may explain deadly link between high salt intake and obesity
9. Crystal structure shows how motor protein works
10. Lack of protein FKBP51 in old mice improves resilience to depressive behavior
11. ORNL invention unravels mystery of protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book on protein homeostasis from Cold Spring Harbor Laboratory Press
(Date:2/8/2016)... , February 8, 2016 ... payment platform which presents innovation for clients, comfort ... feature called VoiceKey. --> Worldcore ... presents innovation for clients, comfort and unbeatable security, ... --> Worldcore is the ...
(Date:2/3/2016)... Vigilant Solutions announces today that the ... Missouri solved two recent hit-and-run cases with ... Vigilant Solutions. Brian Wenberg explains, "I ... was walking out of a convenience store and witnessed an elderly male back ... striking his vehicle and leaving the scene.  In his ...
(Date:2/2/2016)... 2, 2016 Technology Enhancements Accelerate Growth of X-ray ... the digital and computed radiography markets in ... Indonesia (TIM). It provides an ... as well as regional market drivers and restraints. The ... penetration and market attractiveness, both for digital and computed ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... ... February 12, 2016 , ... The Pittcon 2016 Exposition, ... Georgia, will include 848 exhibitors (count as of February 9) of which 119 ... services used by the scientific community in industrial, academic, and government labs. The ...
(Date:2/11/2016)... DIEGO, Feb. 11, 2016  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ... ended December 31, 2015. --> ... a net loss of $29.3 million, or $0.34 loss per share, ... per share for the same period in 2014. For the year ... $88.9 million, or $1.05 loss per share, as compared to a ...
(Date:2/11/2016)... ATLANTA , Feb. 11, 2016  Wellcentive ... a Portland, Oregon -based community ... to provide population health analytics, quality reporting and ... help FamilyCare strengthen its team of quality managers, ... reporting to the provider groups serving FamilyCare members. ...
(Date:2/11/2016)... ... February 11, 2016 , ... Reichert ... years, continues today to pursue the highest level of accuracy and quality with ... AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough enough for ...
Breaking Biology Technology: