Navigation Links
New book offers practical advice for unraveling the genetics of complex human diseases
Date:9/14/2009

COLD SPRING HARBOR, N.Y. (Sept. 14, 2009) Many human diseasesincluding Alzheimer's disease, schizophrenia, cancer, and cardiovascular diseaseare caused by multiple genetic variants and the interaction of those variants with the environment. Because such diseases lack a clear-cut inheritance pattern, sophisticated technological approaches and statistical analyses are required to determine their underlying cause. These approaches and their theoretical basis are the subject of a new book published by Cold Spring Harbor Laboratory Press, Genetics of Complex Human Diseases: A Laboratory Manual.

The book is edited by Ammar Al-Chalabi (MRC Centre for Neurodegeneration Research, King's College London) and Laura Almasy (Southwest Foundation for Biomedical Research, San Antonio, Texas), the lead instructors of the Genetics of Complex Human Diseases course, which is held every other year at Cold Spring Harbor Laboratory. Each chapter is contributed by a former speaker at the course.

"In putting this book together, we have aimed to bring together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin them," write the editors in the introductory chapter of the book. "Anyone with an interest in human genetics or who uses genetic techniques in research will find this book useful, particularly if studying diseases with complex inheritance."

The book's chapters combine practical information and strategic advice about the molecular technologies and statistical tools currently in use with reviews of each topic, providing both the how and the why of complex disease analysis. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the comp
'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New lab test offers better prediction of HIV microbicide safety
2. Biological warfare in bacteria offers hope for new antibiotics
3. MS study offers theory for why repair of brains wiring fails
4. Embryology study offers clues to birth defects
5. Stem cell protein offers a new cancer target
6. Novel vaccine approach offers hope in fight against HIV
7. MIT’s implantable device offers continuous cancer monitoring
8. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
9. Synthetic chemical offers solution for crops facing drought
10. Star Trek-like technology offers noninvasive monitor for patients and athletes
11. Brown-led team offers first look at how bats land
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book offers practical advice for unraveling the genetics of complex human diseases
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the addition of the "The Global ... their offering. ... an overview of the global digital media ... control and monitor piracy by securely and ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... July 2012, Apple introduced the fingerprint reading feature ... only device of Apple incorporating such a feature, ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal ... that pinpoints fine-scale differences in genetic ancestry of individuals ... Since immigrants first arrived more than four ... has served as a meeting place for peoples ... and the ongoing mixing of peoples with African, European, ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Ann Liebert, Inc. is pleased to announce significant growth ... Impact Factors published by Thomson Reuters. More than half ... the majority achieving an increase of 10% and higher. ... editorial standards for exceptional quality, supported by outstanding review ...
... Smithsonian Conservation Biology Institute and George Mason University ... complex that embodies the concept of the living ... Studies Program has trained future conservationists with an ... Smithsonian National Zoological Park,s 3,200-acre facility in Front ...
... YORK, N.Y. (June 30, 2011) Autism Speaks Weatherstone Pre-Doctoral ... a 2010 fellow, recently published new findings in the journal ... autism. Their research is based on a mouse model that ... to be associated with autism spectrum disorder (ASD), known as ...
Cached Biology News:Smithsonian Conservation Biology Institute and George Mason University expand partnership 2Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows 2Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows 3
(Date:12/24/2014)... December 23, 2014 “Preparative & ... HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, ... & Agriculture) - Forecasts to 2019” provides a ... opportunities, current market trends, and strategies impacting the ... estimates and forecasts of the revenue and share ...
(Date:12/24/2014)... York (PRWEB) December 23, 2014 According to ... Long Island Affiliate of ITRA Global, the national office market ... steady recovery. This is evidenced by the third quarter’s ... stock market. Low energy costs have held inflation down ... only negative is the housing market remaining soft. , This ...
(Date:12/24/2014)... BEIJING , Dec. 23, 2014 ... or the "Company"), a leading fully integrated plasma-based ... today announced that its majority-owned subsidiary, Shandong Taibang ... Practices ("GMP") certification from the China Food and ... factor production facility. As previously disclosed in the ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  NeuroLifeSciences ... of mazindol in children with attention deficit/hyperactivity disorder published ... 2014 . The paper, titled "Pilot ... deficit/hyperactivity disorder" ( Konofal et al, Drug ... 2014 ) shows that mazindol might be an ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... Milwaukee-based provider of financial technology solutions selected Opsware ... operations Tuesday. Metavante plans to use Opsware to automate ... center information technology environment. , ,We selected Opsware ... complexity and cost in the data center, said Brian ...
... and be more responsive to the needs of their ... they provide as a result of two new products ... company. API Software announced Tuesday the availability of the ... scheduling application, which recently acquired two new contracts. ...
... Third Wave Technologies Inc. , a Madison-based provider of ... 2003 last Tuesday. The year was transitional for Third ... financial resources away from the genomic tools market and ... revenue of $36.3 million and a net loss of ...
Cached Biology Technology:API Releases New Software, Acquires Additional Contracts 2
... Neogens enzyme-linked immunosorbent assay (ELISA) test ... screening devices for the detection of drugs ... kits are intended for forensic use only. ... be confirmed by a quantitative method such ...
Cag-A (IgG) -Ab EIA Sample Size: 10 l...
... pending) is a protein based inhibitor of ... the most common and troublesome RNases including ... SUPERaseIn can be used in any application ... is ideal for in vitro transcription and ...
... Inhibitor is a recombinant human protein produced in ... neutral pancreatic RNase A type enzymes. The ... binds RNases in a 1:1 ratio. The enzyme ... many tissues and cell types. Addition of the ...
Biology Products: