Navigation Links
New book offers practical advice for unraveling the genetics of complex human diseases
Date:9/14/2009

COLD SPRING HARBOR, N.Y. (Sept. 14, 2009) Many human diseasesincluding Alzheimer's disease, schizophrenia, cancer, and cardiovascular diseaseare caused by multiple genetic variants and the interaction of those variants with the environment. Because such diseases lack a clear-cut inheritance pattern, sophisticated technological approaches and statistical analyses are required to determine their underlying cause. These approaches and their theoretical basis are the subject of a new book published by Cold Spring Harbor Laboratory Press, Genetics of Complex Human Diseases: A Laboratory Manual.

The book is edited by Ammar Al-Chalabi (MRC Centre for Neurodegeneration Research, King's College London) and Laura Almasy (Southwest Foundation for Biomedical Research, San Antonio, Texas), the lead instructors of the Genetics of Complex Human Diseases course, which is held every other year at Cold Spring Harbor Laboratory. Each chapter is contributed by a former speaker at the course.

"In putting this book together, we have aimed to bring together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin them," write the editors in the introductory chapter of the book. "Anyone with an interest in human genetics or who uses genetic techniques in research will find this book useful, particularly if studying diseases with complex inheritance."

The book's chapters combine practical information and strategic advice about the molecular technologies and statistical tools currently in use with reviews of each topic, providing both the how and the why of complex disease analysis. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the comp
'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New lab test offers better prediction of HIV microbicide safety
2. Biological warfare in bacteria offers hope for new antibiotics
3. MS study offers theory for why repair of brains wiring fails
4. Embryology study offers clues to birth defects
5. Stem cell protein offers a new cancer target
6. Novel vaccine approach offers hope in fight against HIV
7. MIT’s implantable device offers continuous cancer monitoring
8. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
9. Synthetic chemical offers solution for crops facing drought
10. Star Trek-like technology offers noninvasive monitor for patients and athletes
11. Brown-led team offers first look at how bats land
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book offers practical advice for unraveling the genetics of complex human diseases
(Date:8/28/2014)... is pleased to announce the selection of Dr. Fred ... Membership acknowledges those who have served ESA for at ... of the Society that has reached an extraordinary level. ... Governing Board and then voted on by the ESA ... Ceremony at Entomology 2014, ESA,s Annual Meeting in Portland, ...
(Date:8/28/2014)... reports that an expansion of marine protected areas is ... functions. According to investigators from the Wildlife Conservation ... have focused on saving the largest numbers of species, ... key and difficult-to-replace ecological functions. , Many ... fish species that also are food for millions of ...
(Date:8/28/2014)... for your neighbors than traditional cigarettes, but still ... new study from USC. , Scientists studying secondhand ... in exposure to harmful particles, with close-to-zero exposure ... some harmful metals in second-hand e-cigarette smoke were ... smoke contains high levels of polycyclic aromatic hydrocarbons ...
Breaking Biology News(10 mins):Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2Second-hand e-cig smoke compared to regular cigarette smoke 2
... The results of a recent study by the University of ... there was a unexpected increase in hydrocarbon levels along the ... Worsened in previous years by works to remove the wreck, ... 2006 along with numerous forest fires., On 19th November 2002 ...
... This press release is available in ... of the University of Montreal,s Department of Chemistry have discovered ... contamination of our water by sewers. " E coli ... of fecal pollution of our water from storm water discharge, ...
... - Researchers are making progress in developing a system ... technology that could be used to diagnose human disease ... an instrument called an atomic force microscope to study ... method,s potentially broad applications, said Arvind Raman, a Purdue ...
Cached Biology News:Hydrocarbon pollution along the coast of Galicia shot up five years after the Prestige oil spill 2Chemistry professor links feces and caffeine 2New medical, research tool possible by probing cell mechanics 2
(Date:8/28/2014)... USA (PRWEB) August 27, 2014 Scientists, ... month for SPIE Laser Damage 2014 symposium. ... materials for high-power lasers will run 14-17 September. The ... for optics and photonics . , The premier conference ... understanding laser damage to optical materials will engage researchers ...
(Date:8/28/2014)... Earlier this month, a report was created ... U.S. Air Force on the performance of vehicles using ... type of fuel made from mustard seeds, offered great ... America’s Eco friendly future. In fact, every branch of ... independent of foreign oil over the next few years. ...
(Date:8/28/2014)... San Diego, CA (PRWEB) August 28, 2014 ... products, Pipette.com is offering a promotion for ... enables Pipette.com customers to purchase the highest quality ... Centrifuge Tubes are ideal for customers doing chemical, ... benefit lab technicians who are not regularly able ...
(Date:8/27/2014)... August 27, 2014 Varian Medical Systems ... its current Salt Lake City manufacturing facility and allow ... Utah to ultimately create 1,000 new full time jobs ... , “Utah is home to hardworking people with immense ... credited with Varian’s success in the manufacturing of our ...
Breaking Biology Technology:Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3
... CV Therapeutics,Inc. (Nasdaq: CVTX ) announced today ... up to $185 million in exchange for rights ... American sales of Lexiscan(TM),(regadenoson) injection. CV Therapeutics received ... receive a potential future milestone payment,of $10 million., ...
... and Families, EMERYVILLE, Calif., April 15 ... two new health care areas designed to,soothe patients ... to offer health resources. The Carol Ann,Read Breast ... procedures, all in one location, for the quickest ...
... April 15 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,(TSX: ONC, ... Dr. Anders,Kolb of the Nemours Center for Childhood ... Pediatric Sarcomas" was,presented today at the American Association ... being held in San Diego, California from,April 12-16, ...
Cached Biology Technology:CV Therapeutics Announces $185 Million Transaction with TPG-Axon Capital for Half of Royalty for Lexiscan(TM) (regadenoson) Injection 2CV Therapeutics Announces $185 Million Transaction with TPG-Axon Capital for Half of Royalty for Lexiscan(TM) (regadenoson) Injection 3Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 3Oncolytics Biotech Inc. Collaborators Present Reovirus Research for Pediatric Sarcomas at AACR Annual Meeting 2
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Human SCP3 Affinity Purified Polyclonal Ab Keywords: Spermatogenesis, meiosis Protein Family: Cell Cycle...
Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5), mRNA....
Human Rad1 MAb (Clone 33)...
Biology Products: