Navigation Links
New book offers practical advice for unraveling the genetics of complex human diseases
Date:9/14/2009

COLD SPRING HARBOR, N.Y. (Sept. 14, 2009) Many human diseasesincluding Alzheimer's disease, schizophrenia, cancer, and cardiovascular diseaseare caused by multiple genetic variants and the interaction of those variants with the environment. Because such diseases lack a clear-cut inheritance pattern, sophisticated technological approaches and statistical analyses are required to determine their underlying cause. These approaches and their theoretical basis are the subject of a new book published by Cold Spring Harbor Laboratory Press, Genetics of Complex Human Diseases: A Laboratory Manual.

The book is edited by Ammar Al-Chalabi (MRC Centre for Neurodegeneration Research, King's College London) and Laura Almasy (Southwest Foundation for Biomedical Research, San Antonio, Texas), the lead instructors of the Genetics of Complex Human Diseases course, which is held every other year at Cold Spring Harbor Laboratory. Each chapter is contributed by a former speaker at the course.

"In putting this book together, we have aimed to bring together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin them," write the editors in the introductory chapter of the book. "Anyone with an interest in human genetics or who uses genetic techniques in research will find this book useful, particularly if studying diseases with complex inheritance."

The book's chapters combine practical information and strategic advice about the molecular technologies and statistical tools currently in use with reviews of each topic, providing both the how and the why of complex disease analysis. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Related biology news :

1. New lab test offers better prediction of HIV microbicide safety
2. Biological warfare in bacteria offers hope for new antibiotics
3. MS study offers theory for why repair of brains wiring fails
4. Embryology study offers clues to birth defects
5. Stem cell protein offers a new cancer target
6. Novel vaccine approach offers hope in fight against HIV
7. MIT’s implantable device offers continuous cancer monitoring
8. Princeton geoscientist offers new evidence that meteorite did not wipe out dinosaurs
9. Synthetic chemical offers solution for crops facing drought
10. Star Trek-like technology offers noninvasive monitor for patients and athletes
11. Brown-led team offers first look at how bats land
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book offers practical advice for unraveling the genetics of complex human diseases
(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
(Date:6/1/2016)... , June 1, 2016 Favorable ... Election Administration and Criminal Identification to Boost Global Biometrics ... recently released TechSci Research report, " Global Biometrics Market ... Competition Forecast and Opportunities, 2011 - 2021", the global ... by 2021, on account of growing security concerns across ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... , June 23, 2016 On Wednesday, ... at 4,833.32, down 0.22%; the Dow Jones Industrial Average edged ... closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on ... ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals ... (NASDAQ: BIND ). Learn more about these stocks ...
Breaking Biology Technology: