Navigation Links
New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity
Date:4/15/2009

COLD SPRING HARBOR, N.Y. If it were not for a group of enzymes called topoisomerases, DNA would become a knotted, coiled, dysfunctional mess inside of a cell as it gets twisted, rolled, unzipped, and pulled by the cellular machinery that reads and copies its sequence. Topoisomerases, which are responsible for relieving this tension and maintaining the integrity of the genome, were first discovered in the 1970s by Harvard's Professor of Biochemistry and Molecular Biology James C. Wang. Wang has written a book that discusses the history of topoisomerases, their mechanisms of action, and their use and potential as therapeutic targets. The book, entitled Untangling the Double Helix, has just been released by Cold Spring Harbor Laboratory Press.

"The primary motivation for [writing this book] is that, despite the gradual recognition of the significance of the DNA entanglement problem in nearly all cellular transactions of DNA, and the finding that many antimicrobial and anticancer therapeutics target the DNA topoisomerases, few articles have been written for the general readership," wrote Wang. The book will appeal to those with a general interest in molecular biology, the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Wang starts with the history of the "insuperable" DNA entanglement problem and describes research that led to the discovery of the DNA topoisomerases. He details the mechanistic features of the different subfamilies of DNA topoisomerases, and explains how cutting-edge laboratory techniques are used to visualize individual enzymes in real time as they break and rejoin DNA molecules in a controlled manner.

Wang describes how topoisomerases perform their magic in DNA replication, transcription, genetic recombination, and chromosome condensation, and ends with a discussion of topoisomerases as targets of therapeutic agents, including antibiotics (such as Cipro) and anticancer drugs. Each of the ten chapters includes key references for those looking for a more comprehensive discussion of a specific topic.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Related biology news :

1. Cells with double vision
2. Tree deaths have doubled across the western US
3. Researchers make breakthrough in the production of double-walled carbon nanotubes
4. Women double fruit, veggie intake with switch to Mediterranean diet plan
5. A double-barreled immune cell approach for neuroblastoma
6. Gaining too much weight during pregnancy nearly doubles risk of having a heavy baby
7. Depression during pregnancy can double risk of preterm delivery
8. Boffinry and Baftas: Brothers double doctorates
9. 55th anniversary of Nobel honoring double helix continues to overlook the late Rosalind Franklin
10. Popcorn-ball design doubles efficiency of dye-sensitized solar cells
11. IEEE-USA commends president for asking Congress to double support for critical research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity
(Date:2/2/2016)... , Feb. 2, 2016 Checkpoint ... that Rising Market Are you interested in ... forecasts revenues for checkpoint inhibitors. Visiongain,s report gives ... submarket, product and national level. Avoid falling ... what progress, opportunities and revenues those emerging cancer ...
(Date:2/2/2016)... 2, 2016   Parabon NanoLabs (Parabon) ... Army Research Office and the Defense Forensics and ... of the company,s Snapshot Kinship Inference ... more generally, defense-related DNA forensics.  Although Snapshot is ... appearance and ancestry from DNA evidence), it also ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: ... pleased to announce that Mitsui & Co. Ltd., its ... succinic acid plant, is investing an additional CDN$25 million ... increasing its stake from 30% to 40%.  Mitsui will ... bio-succinic acid produced in Sarnia , ...
(Date:2/10/2016)... is introducing a hybrid membership model which will provide ... joining or renewing through an organizational purchasing model. For ... employee in any size association or AMC office can ... benefits.   John H. Graham, IV , ... organizations of any size and their employees to gain ...
(Date:2/10/2016)... , Feb. 10, 2016  Matchbook, Inc., ... for fast growing biotech companies, announced today the ... Procurement Strategic Advisor. Jim brings nearly 25 years ... and procurement, having spent nearly two decades in ... Chain/Logistics and Procurement at Genzyme and, most recently ...
(Date:2/10/2016)... ... 2016 , ... SonaCare Medical, LLC reports the introduction of ... monitoring. The inaugural launch of this new technology occurred over the course of ... to a HIFU technical expert at SonaCare Medical headquarters. , Sonalink allows ...
Breaking Biology Technology: