Navigation Links
New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity
Date:4/15/2009

COLD SPRING HARBOR, N.Y. If it were not for a group of enzymes called topoisomerases, DNA would become a knotted, coiled, dysfunctional mess inside of a cell as it gets twisted, rolled, unzipped, and pulled by the cellular machinery that reads and copies its sequence. Topoisomerases, which are responsible for relieving this tension and maintaining the integrity of the genome, were first discovered in the 1970s by Harvard's Professor of Biochemistry and Molecular Biology James C. Wang. Wang has written a book that discusses the history of topoisomerases, their mechanisms of action, and their use and potential as therapeutic targets. The book, entitled Untangling the Double Helix, has just been released by Cold Spring Harbor Laboratory Press.

"The primary motivation for [writing this book] is that, despite the gradual recognition of the significance of the DNA entanglement problem in nearly all cellular transactions of DNA, and the finding that many antimicrobial and anticancer therapeutics target the DNA topoisomerases, few articles have been written for the general readership," wrote Wang. The book will appeal to those with a general interest in molecular biology, the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Wang starts with the history of the "insuperable" DNA entanglement problem and describes research that led to the discovery of the DNA topoisomerases. He details the mechanistic features of the different subfamilies of DNA topoisomerases, and explains how cutting-edge laboratory techniques are used to visualize individual enzymes in real time as they break and rejoin DNA molecules in a controlled manner.

Wang describes how topoisomerases perform their magic in DNA replication, transcription, genetic recombination, and chromosome condensation, and ends with a discussion of topoisomerases as targets of therapeutic agents, including antibiotics (such as Cipro) and anticancer drugs. Each of the ten chapters includes key references for those looking for a more comprehensive discussion of a specific topic.


'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Related biology news :

1. Cells with double vision
2. Tree deaths have doubled across the western US
3. Researchers make breakthrough in the production of double-walled carbon nanotubes
4. Women double fruit, veggie intake with switch to Mediterranean diet plan
5. A double-barreled immune cell approach for neuroblastoma
6. Gaining too much weight during pregnancy nearly doubles risk of having a heavy baby
7. Depression during pregnancy can double risk of preterm delivery
8. Boffinry and Baftas: Brothers double doctorates
9. 55th anniversary of Nobel honoring double helix continues to overlook the late Rosalind Franklin
10. Popcorn-ball design doubles efficiency of dye-sensitized solar cells
11. IEEE-USA commends president for asking Congress to double support for critical research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... 2016 , ... The Ankle Plating System 3 and Small ... fractures of the distal tibia and fibula. This system marks Acumed's continued commitment ... is composed of seven plate families that span the lateral, medial, and posterior ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... (RFI) issued by the Office of the National Coordinator for Health IT (ONC) ... determines if clinically relevant data were available when and where it was needed. ...
(Date:5/25/2016)... CITY, UTAH. (PRWEB) , ... May 25, 2016 , ... ... in healthcare information exchange, today announced that Charles W. Stellar has been named by ... WEDI’s interim CEO since January 2016. As an executive leader with more than 35 ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... Drug Administration (FDA) has granted the company’s orphan drug designation request covering BHV-4157 ... drug designation granted by the FDA. , Spinocerebellar ataxia is a rare, ...
Breaking Biology Technology: