Navigation Links
New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity
Date:4/15/2009

COLD SPRING HARBOR, N.Y. If it were not for a group of enzymes called topoisomerases, DNA would become a knotted, coiled, dysfunctional mess inside of a cell as it gets twisted, rolled, unzipped, and pulled by the cellular machinery that reads and copies its sequence. Topoisomerases, which are responsible for relieving this tension and maintaining the integrity of the genome, were first discovered in the 1970s by Harvard's Professor of Biochemistry and Molecular Biology James C. Wang. Wang has written a book that discusses the history of topoisomerases, their mechanisms of action, and their use and potential as therapeutic targets. The book, entitled Untangling the Double Helix, has just been released by Cold Spring Harbor Laboratory Press.

"The primary motivation for [writing this book] is that, despite the gradual recognition of the significance of the DNA entanglement problem in nearly all cellular transactions of DNA, and the finding that many antimicrobial and anticancer therapeutics target the DNA topoisomerases, few articles have been written for the general readership," wrote Wang. The book will appeal to those with a general interest in molecular biology, the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Wang starts with the history of the "insuperable" DNA entanglement problem and describes research that led to the discovery of the DNA topoisomerases. He details the mechanistic features of the different subfamilies of DNA topoisomerases, and explains how cutting-edge laboratory techniques are used to visualize individual enzymes in real time as they break and rejoin DNA molecules in a controlled manner.

Wang describes how topoisomerases perform their magic in DNA replication, transcription, genetic recombination, and chromosome condensation, and ends with a discussion of topoisomerases as targets of therapeutic agents, including antibiotics (such as Ci
'/>"/>

Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cells with double vision
2. Tree deaths have doubled across the western US
3. Researchers make breakthrough in the production of double-walled carbon nanotubes
4. Women double fruit, veggie intake with switch to Mediterranean diet plan
5. A double-barreled immune cell approach for neuroblastoma
6. Gaining too much weight during pregnancy nearly doubles risk of having a heavy baby
7. Depression during pregnancy can double risk of preterm delivery
8. Boffinry and Baftas: Brothers double doctorates
9. 55th anniversary of Nobel honoring double helix continues to overlook the late Rosalind Franklin
10. Popcorn-ball design doubles efficiency of dye-sensitized solar cells
11. IEEE-USA commends president for asking Congress to double support for critical research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity
(Date:2/5/2015)... , Jan. 26, 2015 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... website ( http://www.nxt-id.com/ ) as part of its 2015 ... The Company launched its new consumer website for Wocketwallet.com ... , CEO of NXT-ID said, "Our new corporate website ...
(Date:2/5/2015)... , Jan. 28, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... upcoming RedChip Global Online CEO Conference on January 29 ... Gino Pereira , CEO of NXT-ID will present ... product, the Wocket smart wallet and its full suite ...
(Date:2/5/2015)... VIEW, Calif. , Feb. 3, 2015 /PRNewswire/ ... printer technology, demand from industries such as consumer ... global market for surface mount technology (SMT) screen ... equipment to automatic control will push the adoption ... dispensers will remain steady as glue dispensers are ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3
... Philadelphia, PA, May 2, 2012 Although the ... associated. Individuals with epilepsy are more likely to have ... risk factor for psychosis. It is not known whether ... of psychosis is a risk factor for epilepsy. ...
... Infants born to women who used the anti-HIV drug tenofovir ... not weigh less at birth and are not of shorter ... regimens that do not include tenofovir during pregnancy, according to ... However, at 1 year of age, children born to ...
... to sneak up on a huge dinosaur while it sleeps, crawl ... have felt like a needle going in but giant "flea-like" ... just that. And a few actually lived through the experience, ... these creatures, just announced in Current Biology, a professional ...
Cached Biology News:Evidence of familial vulnerability for epilepsy and psychosis 2Anti-HIV drug use during pregnancy does not affect infant size, birth weight 2Anti-HIV drug use during pregnancy does not affect infant size, birth weight 3Jurassic pain: Giant 'flea-like' insects plagued dinosaurs 165 million years ago 2
(Date:2/27/2015)... Brighton, Illinois (PRWEB) February 27, 2015 ... Matt Sims, General Manager of State Line Farms, received ... Award recognizes a producer, under the age of 35, ... , "It is an honor to win the Tomorrow's ... to discovering who won the Top Producer Award and ...
(Date:2/26/2015)... -- On behalf of biotech client GenScript USA, ... & Spitzer, P.A. (Wilentz) secured a significant jury verdict ... excess of $10 million. The jury determined that Genewiz ... it improperly hired one or more of GenScript,s employees.  ... notwithstanding the verdict, a new trial, and remittitur. ...
(Date:2/26/2015)... MENLO PARK, Calif. , Feb. 26, 2015 /PRNewswire/ ... has released the latest version of the Governance ... organizations accomplish governance, risk and compliance (GRC) tasks across ... has also been updated to help customers better align ... Organizations of the Treadway Commission ) requirements. In response ...
(Date:2/26/2015)... The healthcare landscape is rapidly and radically changing. ... will host its 20 th Anniversary Medical Technologies ... to 10, at the Hilton San Diego Resort and Spa ... This event is a platform for global medical devices, diagnostics, ... and how to succeed in an uncertain future. ...
Breaking Biology Technology:Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3Embrace the Future of Medical Technologies with Frost & Sullivan 2Embrace the Future of Medical Technologies with Frost & Sullivan 3
... COATED PLATE ASSAYS , ... the counting of radioimmunoassays based on coated microtitration plates. The following method ... compare the standard immunoassay microtitration plates with those manufactured by PerkinElmer Life ... procedure is straightforward: , (1) Coat ...
... , ... Dpartement dImmunologie, Laboratoires Fournier S.A., France ... TGF- type I and type II receptors ... type II (TRII) tends to act as the primary receptor. In the ...
... L. Smith1, M.J. Price-Jones 1 , K.T. ... plc., Forest Farm, Whitchurch, Cardiff, CF4 7YT, Wales, UK, 2 PerkinElmer ... , INTRODUCTION ... a multi-detector instrument designed for liquid scintillation (LS) or luminescence detection of samples ...
Cached Biology Technology:Coated Plate Immunoassay on the MicroBeta - eg. TSH - IRMA 2Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 2Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 3Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 4Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 5Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 6Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor 7Counting Cytostar-T scintillating microplates on the MicroBeta JET 2Counting Cytostar-T scintillating microplates on the MicroBeta JET 3Counting Cytostar-T scintillating microplates on the MicroBeta JET 4Counting Cytostar-T scintillating microplates on the MicroBeta JET 5
... Immulon 2HB ELISA ... provide increased binding affinity for hydrophilic ... bottom works well for reagent injection ... Each strip accomodates ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
... positively and negatively supercoiled DNA in presence of ... the effects of supercoiling on transcription in vitro ... , Determining the degree of supercoiling of naturally ... differ in length by only one base-pair ...
... Kit for Kilo-Sequencing is designed to aid ... into the multiple cloning sites (MCS) of ... or phagemid vectors (pUC18/19). The kit is ... the target DNA, thereby progressively moving the ...
Biology Products: