Navigation Links
New blood-thinning drug safer than rat poison
Date:9/29/2009

In an article reviewed by F1000 Medicine Faculty Members Robert Ruff, Brian Olshansky and Luis Ruilope, the blood-thinner dabigatran is shown to protect against stroke, blood clotting and major bleeding as effectively as warfarin, but with fewer side effects.

The original paper, Dabigatran versus warfarin in patients with atrial fibrillation, by Neal Devaraj and Stuart Connolly et al. in the New England Journal of Medicine, says warfarin (also commonly used in rat poison) has several drawbacks. Finding the correct dosage requires careful and laborious monitoring, and the risk of major bleeding has led to it being under-used.

With fewer side-effects and complications than warfarin, the reviewers see many potential benefits from dabigatran. According to Olshansky, it is "perhaps one of the important drug discoveries in the past decade."

Ruilope says that according to the investigators, "This oral anticoagulant prevents strokes and peripheral embolic events in patients with atrial fibrillation significantly better than that much older drug (warfarin) at different doses. It is also safer than warfarin with respect to major bleeding events."

"An immediate change of practice is not warranted but a change in standard anticoagulant therapy may be needed," Ruilope says.


'/>"/>

Contact: Steve Pogonowski
press@f1000.com
Faculty of 1000: Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. MIT works toward safer gene therapy
2. New drug makes weight loss safer
3. Jumping genes could make for safer gene delivery system
4. Safer, more accurate radiation therapy for expecting mothers
5. Scientists discover how cigarette smoke causes cancer: Study points to new treatments, safer tobacco
6. NIST trumps the clumps: Making biologic drugs safer
7. Researchers create safer alternative to heparin
8. NPL unveils new equipment to make cancer treatment safer
9. Queens University Belfast plays leading role in Europe-wide tests for safer food
10. Researchers piggyback to safer reprogrammed stem cells
11. Oh baby, interventional radiology makes childbirth safer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Athens, Ga. An international team of scientists including researchers ... Brassica napus commonly known as canolain the journal ... of the plant, which is used widely in farming and ... and its native Europe, but the winter crop is increasingly ... for its naturally low levels of saturated fat and rich ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... darkness use a previously unknown process for harvesting energy ... by a Penn State University scientist has discovered. The ... improving plant growth, harvesting energy from the Sun, and ... Erie and other lakes worldwide. A paper describing the ... Express edition of the journal Science on ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3
... findings about life in the heart of Yellowstone National ... years of Montana State University research. The book ... Sixteen Years of Integrated Field Studies" covers many of ... attention, said editor and MSU ecologist Robert A. Garrott. ...
... role in the disparity between the numbers of African ... the disease. A study by researchers at the Johns ... disparity was substantially reduced when comparing groups of African ... The results are published in the November 2008 print ...
... | Union County New Mexico is a landscape of striking ... cone volcanoes and mesas preserved by basalt, part of the ... is the youngest volcano in the field. The cone rises ... m above sea level. The base of the volcano is ...
Cached Biology News:New book covers 16 years of MSU research in Yellowstone 2New book covers 16 years of MSU research in Yellowstone 3Hypertension disparity linked to environment 2Scientists map soils on an extinct American volcano 2
(Date:8/21/2014)... August 21, 2014 Gallus ... contract development and manufacturing organization (CMO) announced today ... Inc., an oncology company focused on the development ... to manufacture the anti-prostate specific membrane antigen (PSMA) ... candidate. Under the agreement the antibody will ...
(Date:8/21/2014)... On Wednesday of last week RENU 28, the ... molecules, became available for purchase in Australia and New Zealand, ... RENU 28 works is, if you think about the definition ... of cellular renewal within your body. If you think about ... of cellular renewal. What RENU 28 does is it works ...
(Date:8/20/2014)... analysis of patented university inventions licensed to biotechnology ... to commercialization. To open these roadblocks, the researchers ... during the discovery stage could lead to faster ... frequently derived from discoveries made in university laboratories ... known during clinical trials, which have a high ...
(Date:8/20/2014)... the first time, chemists have succeeded in measuring vibrational ... resolution. The study reveals how vibration of a single ... , The study was performed at the University ... the University of Jyvskyl works as a visiting fellow ... the study. The second team was lead by Professor ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3RENU 28 Skin Care Now Available in Australia and New Zealand 2Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Seeing a molecule breathe 2
... PharmaVentures announced today that it was delighted ... US and Canada as Merck & Co) to secure its ... Nottingham and Roslin BioCentre, for the former MSD research facility ... working between MSD, the Scottish Life Sciences community and the ...
... 17, 2012  Cepheid (Nasdaq: CPHD ) today ... the position of Senior Vice President, Human Resources, effective ... Cepheid from Verigy, Inc., a wholly owned subsidiary of ... Vice President of Human Resources.  Prior to Verigy, Mr. ...
... from a Nobel Laureate. Find out how major discoveries ... policy, education, and research in other countries. The iBioSeminars ... online, on-demand, and for free. iBioSeminars ... biology seminars given by the world,s leading researchers. The ...
Cached Biology Technology:PharmaVentures Helps Secure Investor for Former MSD Research Site 2Cepheid Welcomes Senior Vice President of Human Resources 2iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists 2
HLA-DRbeta (DA2)...
... to Cytokeratin 5 / 6 Cytokeratin ... weight, basic type of cytokeratin expressed in ... layers of stratified epithelia as well as ... cells and mesothelioma. Cytokeratin 6 (56 kD) ...
...
Aldolase A (N-15)...
Biology Products: