Navigation Links
New blood test for Down syndrome
Date:10/6/2008

Howard Hughes Medical Institute researchers have developed a new prenatal blood test that accurately detected Down syndrome and two other serious chromosomal defects in a small study of 18 pregnant women. If confirmed in larger trials, they say, the test would offer a safer and faster alternative to invasive prenatal tests such as amniocentesis that pose a small risk of miscarriage.

Researchers have long known that a pregnant woman's blood contains small amounts of DNA from the fetus. Howard Hughes Medical Institute researcher Stephen R. Quake and colleagues at Stanford University devised an ingenious way to the scan fetal DNA present in the mother's blood to determine whether the fetus' cells contain extra chromosomes associated with several types of severe birth detects.

The test developed by Quake's team was more accurate than techniques used in previous efforts to diagnose aneuploidy by analyzing fetal DNA. Aneuploidy occurs when there are either too many or too few chromosomes in cells. Down syndrome, for example, is caused by a trisomy -- three copies instead of two -- of chromosome 21.

"We believe this is the first demonstration of a universal, noninvasive test for Down and other aneuploidies," said Quake, senior author of the research article, which was published online in the early edition of the Proceedings of the National Academy of Sciences (PNAS) on October 6, 2008. "We need a larger clinical study to understand a bit more about the best way to implement it, but I am highly optimistic it will be used as a diagnostic test in short order."

Amniocentesis and chorionic villus sampling (CVS), which are currently considered the "gold standard" in prenatal testing, involve sampling cells in amniotic fluid. Those cells are obtained by inserting a needle into the mother's uterus. The procedure carries up to a one percent risk of inducing a miscarriage. For that reason, routine use of these invasive diagnostic tests has largely been li
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Discovery of natural compounds that could slow blood vessel growth
2. Scientist plans to test for blood pressure genes affected by age
3. High blood pressure takes big toll on small filtering units of the kidney
4. Better understanding of blood vessel constrictor needed to harness its power for patients
5. Protein identified that plays role in blood flow
6. Prosthetic vein valve designed to direct blood flow shows promising pre-clinical results
7. Pivotal national trial uses newest interventional radiology treatment to bust blood clots in legs
8. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
9. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
10. Blood fingerprints for cancer
11. Researchers devise means to create blood by identifying earliest stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... whereby the genetic information of DNA is used ... have numerous different functions in living organisms. Messenger ... gene expression, by relating the genetic information of ... proteins. , By examining the different types ... organism at a given time, researchers can determine ...
(Date:4/17/2014)... have uncovered a new way the immune system may ... efforts to use immune cells to treat illness. , ... the immunological equivalent of "neighborhood police" specialized squads ... organ, instead of an entire city, the body. , ... Louis have shown that the liver, skin and uterus ...
(Date:4/17/2014)... domestication derive from Charles Darwin, whose ideas in ... during the 19th century, a period when landowners ... is from Darwin that we inherit the ideas ... wild species and total human control over breeding ... this industrial setting has been applied too broadly ...
Breaking Biology News(10 mins):Rapid and accurate mRNA detection in plant tissues 2Some immune cells defend only 1 organ 2The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4
... more attractive to women seeking short-term relationships, scientists at ... previously assumed that in Western cultures scarring was an ... perceived as a sign of maturity and strength. ... that Western women find scarring on men attractive and ...
... the presidential campaign, Barack Obama proposed an economic plan ... These so-called "green collar" jobs do, in fact, present ... report from Duke University. , Highlighting the direct ... say U.S. manufacturing is poised to grow in a ...
... A new study confirms that exercise can reverse the ... in the hippocampus of the mouse brain, and suggests ... which promotes the production and maturation of new stem ... into a variety of mature nerve cells which have ...
Cached Biology News:Scientists find facial scars increase attractiveness 2Duke study pinpoints potential 'green collar' job growth in US 2Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age 2Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age 3
(Date:1/15/2014)... is the device," Nobel laureate Herbert Kroemer famously ... found at the junctures where layers of different ... the interfaces between layers of metal oxides are ... favorites as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. ...
(Date:1/15/2014)... 2014 The Pittcon Organizing Committee is pleased ... Safety Tech , an e-Journal and producer of ... the second year for the co-location of Food Labs Conference ... provides that the registration fee to attend the two-day Food ...
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
Breaking Biology Technology:A deeper look at interfaces 2Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3
... online library of cellular images freely available to biomedical ... anniversary on August 9, 2011 by winning The ... The Scientist announced the readers, choice multimedia winners ... The Cell has more than 3,000 searchable images posted. ...
... DUNDEE, Scotland, Sept. 1, 2011 Aridhia Informatics ... partnership to create innovative products to aid the ... outcomes. Anticipating an increased focus on ... will work together to create products for the ...
... The medical imaging company SyntheticMR AB, a subsidiary ... their magnetic resonance imaging software from Umeå University Hospital ... in clinical practice to monitor the treatment efficacy of ... includes tools to automatically estimate a measure for brain ...
Cached Biology Technology:Free Online Library of Cell Images Wins 'The Labby' 2Pioneering US/Scottish Alliance for Life Science and Clinical Informatics 2Pioneering US/Scottish Alliance for Life Science and Clinical Informatics 3Pioneering US/Scottish Alliance for Life Science and Clinical Informatics 4Swedish University Hospital Improves Monitoring of Treatment Efficacy in Multiple Sclerosis With Synthetic MRI Innovation 2Swedish University Hospital Improves Monitoring of Treatment Efficacy in Multiple Sclerosis With Synthetic MRI Innovation 3
... The S.c. EasyComp Transformation Kit ... transformation-competent Saccharomyces cerevisiae cells. Advantages over ... spheroplast formation or LiCl methods include:- Cells ... than 30 minutes - Competent cell preparation ...
...
... System is used in conjunction ... PCR of problematic and/or GC-rich ... Solution with 10X PCRX Amplification ... broader magnesium concentration broader annealing ...
Mouse Exodus 2 - 12kDa...
Biology Products: