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New bitter blocker discovered
Date:6/2/2011

" said Integral Molecular senior author Joseph B. Rucker, Ph.D. "This knowledge will help us develop more potent bitter taste inhibitors."

A series of human sensory studies established that probenecid robustly inhibited the bitter taste of salicin, a compound that stimulates one of the target receptors.

"This demonstrates how we can take in vitro experiments and go on to show how they make a difference functionally and perceptually," said Breslin.

Additional studies will continue to explore the structure and function of TAS2Rs. The overall goal is to identify the regions of the receptors that contribute to bitter molecule binding and how binding events lead to signaling events within the cell.

Understanding modulation of bitter receptor function may have additional implications for the respiratory and gastrointestinal systems, as bitter taste receptors also are expressed in the nose, the lungs and the intestines.


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Contact: Leslie Stein
stein@monell.org
267-619-4707
Monell Chemical Senses Center
Source:Eurekalert

Page: 1 2

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