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New biosensors reveal workings of anti-psychotic drugs in the living brain
Date:12/13/2009

ated a deeper part of the brain in a way known to release acetylcholine nearby. They saw a color change, evidence that the CNiFERs were working. Then they gave the rats one of two atypical neuroleptics. In both cases, the drug severely depressed the response, indicating that the drugs' receptor-blocking action overrides the increase in acetylcholine they report online in Nature Neuroscience December 13.

CNiFERs could be re-designed to detect the activity of other types of receptors as well, work that is underway. "The technique puts CNiFERs together from easily obtained molecular components," said Quoc-Thang Nguyen, a former research associate in Kleinfeld's lab who shares lead authorship with Schroeder. Nguyen recently founded Femtoscience, a company that has licensed the technology from UC San Diego and will develop it as a way to screen drugs.


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Contact: David Kleinfeld
scinews@ucsd.edu
University of California - San Diego
Source:Eurekalert  

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