Navigation Links
New biosensors reveal workings of anti-psychotic drugs in the living brain
Date:12/13/2009

Scientists have resolved a question about how a popular class of drugs used to treat schizophrenia works using biosensors that reveal previously hidden components of chemical communication in the brain.

Although delusions and hallucinations characterize the illness, people with schizophrenia also struggle to sustain attention or recall information in a particular order, difficulties that interfere with their ability to hold a job or function well, said Lee Schroeder, a student in the medical scientist training program at the University of California, San Diego.

A class of drugs called atypical neuroleptics has become the most commonly prescribed treatment for schizophrenia, in part for their ability to improve these cognitive functions. How they altered brain chemistry was uncertain, however. Atypical neuroleptics elicit large releases of the neurotransmitter acetylcholine. But they had also been shown to barricade a particular type of receptor on the receiving cell's surface, which would block the message.

The question was, which action prevails? The answer might guide the development of more effective drugs with fewer side effects. "The hunt is now on," said Schroeder, who shares lead authorship on the paper. "What about these drugs helps? That's where our cells come in."

To find out, the team designed biological cells that change color when acetylcholine latches onto this particular class of receptors, called M1. That allowed them to see when M1 receptors received the chemical message, an event neuroscientists had previously been unable to detect in a living, intact brain. "It's a world of signaling between cells that we were blind to before," said David Kleinfeld, professor of physics and member of UC San Diego's center for neural circuits and behavior, who led the collaboration that invented the system.

The team implanted the cells, which they call CNiFERs (pronounced "sniffers"), in rat brains, then stimul
'/>"/>

Contact: David Kleinfeld
scinews@ucsd.edu
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Study reveals H1N1 unexpected weakness
3. Old hay and Alpine ibex horns reveal how grasslands respond to climate change
4. UBC geneticist reveals molecular view of key epigenetic regulator
5. Study reveals how Arctic food webs affect mercury in polar bears
6. The cause behind the characteristic shape of a long leaf revealed
7. Research reveals exactly how coughing is triggered by environmental irritants
8. Research reveals lipids unexpected role in triggering death of brain cells
9. Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers
10. $15 million stimulus award creates national consortium for revealing scientific resources
11. Inconspicuous leaf beetles reveal environments role in formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New biosensors reveal workings of anti-psychotic drugs in the living brain
(Date:12/11/2014)... 10, 2014  Data Sciences International (DSI), the ... a new series of digital telemetry implants to ... M series, part of the PhysioTel™ Digital platform, ... possible physiologic data when incorporating functional endpoints into ... to toxicology studies has evolved from short ECG ...
(Date:12/10/2014)... RALEIGH, N.C. , Dec. 9, 2014  Valencell, ... announced it is seeing a staggering demand from its ... demand, the Company revealed, is not solely coming from ... industries as well. "A wearable is only ... a result, accuracy is the ultimate driver in long-term ...
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE ... collaboration catalyst that provides the connective tissue that enhances ... enabling them to easily share client-level information; earned a ... to expand to organizations serving seniors aging in community ... Diego" partner on December 11 th 4-6p. ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... of voices they hear to the number of faces ... The finding indicates that numerical perception is truly an ... particular sense, said the researchers. The experimental approach also ... before they have a verbal capacity, understand similar abstract ...
... the United States, independent pet rescue organizations are ... in loving new homes. Although the majority of ... foster homes, they're successfully winning high visibility for ... the 100th annual meeting of the American Sociological ...
... in an escalating 'arms race' with infectious bacteria, as scientists ... evolve new resistance strategies. But now, researchers have a ... the race -- reproducing in the lab the natural evolution ... of scientists in Argentina and Mexico identified mutations that increased ...
Cached Biology News:Monkeys understand numbers across senses 2Virtual animal shelters ?How the Internet is transforming the experience of pet adoptions 2Gaining ground in the race against antibiotic resistance 2Gaining ground in the race against antibiotic resistance 3
(Date:12/19/2014)...  Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... a privately held company based in ... a big data platform for centralized management and ... proprietary on-market Genomic Management Solution, Bina-GMS 1 , ... fast and scalable analyses to maximize the value ...
(Date:12/19/2014)... FL (PRWEB) December 18, 2014 ... the nation’s leading specialty pharmacies, has an expanded ... as clinical pharmacy consultants for prescriber offices in ... expertise. , “We have a variety of ... For example, those specializing in hepatitis C help ...
(Date:12/19/2014)... Reports from CDC show approximately ... one or more chronic health conditions - including cardiovascular ... some of these diseases, but may not eliminate the ... While implanted nerve stimulation devices today offer relief, they ... can induce side effects. , To eliminate the ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2
... EnviroChip™ white papers show how consumers like you can save ... your engine. , ... Denver (PRWEB) July 28, 2008 ... EnviroChip™, a revolutionary fuel harmonizing microchip, can eliminate a consumer,s need ...
... 25 BioTrends Research Group, Inc.,released its 10th ... insight into the management of,renal anemia and bone ... Dialysis. The report provides information from 182 US,Nephrologists ... fielded in,June 2008., In the renal anemia ...
... (Amex: CPD ) posted net sales for the ... $108.3 million, as compared to $35.4,million for the corresponding ... over the first quarter of Fiscal 2008. Pre-tax income ... 2009 as compared to a,pre-tax income of $9.6 million ...
Cached Biology Technology:BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 3Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 4Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 5Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 6Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 7
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
2'-Fluorine-CTP (2'-F-CTP) is readily incorporated into transcripts by T7 and SP6 R&DNA™ Polymerase and is available separately....
Human Glypican 2 Biotinylated Affinity Purified PAb...
Tachykinin (H-2)...
Biology Products: