Navigation Links
New biosensor microchip could speed up drug development, Stanford researchers say
Date:4/19/2011

was not involved in the research.

Members of Wang's research group developed the magnetic nanosensor technology several years ago and demonstrated its sensitivity in experiments in which they showed that it could detect a cancer-associated protein biomarker in mouse blood at a thousandth of the concentration that commercially available techniques could detect. That research was described in a 2009 paper in Nature Medicine.

The researchers tailor the nanotags to attach to the particular protein being studied. When a nanotag-equipped protein binds with another protein that is attached to a nanosensor, the magnetic nanotag alters the ambient magnetic field around the nanosensor in a small but distinct way that is sensed by the detector.

"Let's say we are looking at a breast cancer drug," Gaster said. "The goal of the drug is to bind to the target protein on the breast cancer cells as strongly as possible. But we also want to know: How strongly does that drug aberrantly bind to other proteins in the body?"

To determine that, the researchers would put breast cancer proteins on the nanosensor array, along with proteins from the liver, lungs, kidneys and any other kind of tissue that they are concerned about. Then they would add the medication with its magnetic nanotags attached and see which proteins the drug binds with and how strongly.

"We can see how strongly the drug binds to breast cancer cells and then also how strongly it binds to any other cells in the human body such as your liver, kidneys and brain," Gaster said. "So we can start to predict the adverse affects to this drug without ever putting it in a human patient."

It is the increased sensitivity to detection that comes with the magnetic nanotags that enables Gaster and Wang to determine not only when a bond forms, but also its strength.

"The rate at which a protein binds and releases, tells how strong the bond is," Gaster said. That
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. K-State chemists biosensor may improve food, water safety and cancer detection
2. Directed self-assembly of vertical nanotubes for biosensors, logic, nano-biofuel cells
3. Carnegie Mellon researchers create fluorescent biosensor to aid in drug development
4. Carbon nanotubes form ultrasensitive biosensor to detect proteins
5. Biosensors reveal how single bacterium gets the message to split into a swimming and a stay-put cell
6. UCLA researchers show how worlds smallest coffee ring may help biosensors detect disease
7. New biosensors reveal workings of anti-psychotic drugs in the living brain
8. UTSA wins $500,000 to develop biosensor and regenerative medicine Ph.D. program
9. Nano-tetherball biosensor precisely detects glucose
10. Photonic crystal biosensors detect protein-DNA interactions
11. Microchip patented which separates and extracts tumor cells in the blood
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New biosensor microchip could speed up drug development, Stanford researchers say
(Date:7/10/2014)... in New Mexico, nearly every public golf course is ... potable water supplies. Across the U.S. Southwest as a ... treated effluent. Reusing the effluent increases the sustainability of ... alike fertilize their lawns during the growing season. The ... State University turfgrass expert has a new vision for ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
(Date:7/10/2014)... SPRINGS, Florida , July 1, 2014 ... wallets pave way for convenience and improved security: NXT-ID, Inc. ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) ... is pleased to announce that the second series of 30 ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... The old balkanized approach to ocean management, in which ... and administered by different agencies, has failed to protect ... panel of international scientists says, and should be replaced ... The panel, organized by scientists from Duke University, ...
... new and cleaner ways to meet the country,s energy ... new fuel source. The approach has the potential to ... contributing to rural economic development and lowering greenhouse emissions. ... volumes of diesel and jet transportation fuels. One of ...
... new paper by researchers at George Mason University and the ... between the diversity of organisms at the bottom of the ... Mark D. Uhen, a geologist at Mason, says that ... of whale species living at any given time period correlates ...
Cached Biology News:Marine spatial planning: A more balanced approach to ocean management 2Marine spatial planning: A more balanced approach to ocean management 3Marine spatial planning: A more balanced approach to ocean management 4Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 2Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 3Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 4New study finds link between marine algae and whale diversity over time 2
(Date:7/10/2014)... ST. PETERSBURG, Russia , July 10, 2014 /PRNewswire/ ... the Russian Federation Dmitry Medvedev , presented ... a biopharmaceutical company BIOCAD . The Company is ... the scope of MabNext project BIOCAD develops a number ... of cancer and autoimmune diseases. The ceremony took place ...
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
(Date:7/10/2014)... --  Ceres, Inc . (Nasdaq: CERE ), ... results for the three months ended May 31, 2014 ... Ceres reported that the company and its customers have ... in Brazil, which concluded in June, despite dry and ... for part of the growing season. Yields of several ...
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... Chromatography and Mass Spectrometry Application Report , ... Shieh, Thermo Electron Corporation, San Jose, CA , ... Use of LC/MS n has experienced a dramatic ... screening to ADME/Tox studies. The Finnigan LCQ series ion trap mass spectrometers ...
... , Larry Simonson and Lynn ... Life Sciences Inc, Applications Laboratory, Hopkinton, Massachusetts, USA , ... Initially, work in 96 well microplates was commonly ... of plate processing has grown, automated liquid handling has become a ...
... Geoffrey Grove, Susan Ryan and Ed Alderman ... Technology Department, Caliper Life Sciences, Inc., Hopkinton, MA 01748 , ... The High Volume Head is one of four ... The architecture of the device includes an array of 96 pistons, which ...
Cached Biology Technology:Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 2Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 3Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 4384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 2384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 3384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 2Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 3Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 5Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 6
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... other fluid sources for 8 vessels while ... each individual pump is controlled electronically. Both, ... maintained. ,High-precision controlled miniature pumps can ... allows flow rates between 0 and 420 ...
The Mu-End™ Protein Truncation Kit provides a convenient method for generating a library of N-terminal and C-terminal protein deletions that can be expressed in E. coli....
... The loxP-amp-loxP cassette is ... cells. The prokaryotic promoter gb2 driving ... slightly modified version of the Em7 promoter. ... generally used Tn5 promoter. A synthetic polyadenylation ...
Biology Products: