Navigation Links
New biosensor microchip could speed up drug development, Stanford researchers say
Date:4/19/2011

Stanford researchers have developed a new biosensor microchip that could significantly speed up the process of drug development. The microchips, packed with highly sensitive "nanosensors," analyze how proteins bind to one another, a critical step for evaluating the effectiveness and possible side effects of a potential medication.

A single centimeter-sized array of the nanosensors can simultaneously and continuously monitor thousands of times more protein-binding events than any existing sensor. The new sensor is also able to detect interactions with greater sensitivity and deliver the results significantly faster than the present "gold standard" method.

"You can fit thousands, even tens of thousands, of different proteins of interest on the same chip and run the protein-binding experiments in one shot," said Shan Wang, a professor of materials science and engineering, and of electrical engineering, who led the research effort.

"In theory, in one test, you could look at a drug's affinity for every protein in the human body," said Richard Gaster, MD/PhD candidate in bioengineering and medicine, who is the first author of a paper describing the research that was published online this month by Nature Nanotechnology.

The power of the nanosensor array lies in two advances. First, the use of magnetic nanotags attached to the protein being studied such as a medication greatly increases the sensitivity of the monitoring.

Second, an analytical model the researchers developed enables them to accurately predict the final outcome of an interaction based on only a few minutes of monitoring data. Current techniques typically monitor no more than four simultaneous interactions and the process can take hours.

"I think their technology has the potential to revolutionize how we do bioassays," said P.J. Utz, associate professor of medicine (immunology and rheumatology) at Stanford University Medical Center, who
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. K-State chemists biosensor may improve food, water safety and cancer detection
2. Directed self-assembly of vertical nanotubes for biosensors, logic, nano-biofuel cells
3. Carnegie Mellon researchers create fluorescent biosensor to aid in drug development
4. Carbon nanotubes form ultrasensitive biosensor to detect proteins
5. Biosensors reveal how single bacterium gets the message to split into a swimming and a stay-put cell
6. UCLA researchers show how worlds smallest coffee ring may help biosensors detect disease
7. New biosensors reveal workings of anti-psychotic drugs in the living brain
8. UTSA wins $500,000 to develop biosensor and regenerative medicine Ph.D. program
9. Nano-tetherball biosensor precisely detects glucose
10. Photonic crystal biosensors detect protein-DNA interactions
11. Microchip patented which separates and extracts tumor cells in the blood
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New biosensor microchip could speed up drug development, Stanford researchers say
(Date:9/2/2014)... AGU,s blogs: Earthquake rupture through a U.S. suburb ... of California Davis in the hours and days after ... scientists understand why the earthquake caused so much damage ... Trembling Earth blog, hosted by the American Geophysical Union. ... Mars Rovers: The Next Places to Direct Our Curiosity ...
(Date:9/2/2014)... On September 3, The Field Museum will present the ... recognition of his commitment to biodiversity conservation awareness. The ... honor an outstanding individual, team or organization whose efforts ... rich natural heritage and whose actions can serve as ... founder of Mongabay.com, an environmental science and conservation news ...
(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
Breaking Biology News(10 mins):This week From AGU: California earthquake, future Mars rovers, models underestimate ozone 2Exceptionally well preserved insect fossils from the Rhône Valley 2
... The work of molecular biologist Joseph M. Miano, ... Miano helps head the Aab Cardiovascular Research Institute and ... and Pediatrics program at the University of Rochester Medical ... was highly unlikely, shared enthusiasm, intense curiosity and a ...
... of researchers from the University of Valladolid (Spain) has analysed ... free iron than pale and non-alcoholic beers. Iron is essential ... compounds that give these beverages stability and flavour. According ... (UVa) on 40 types of beers from all 5 continents, ...
... Scientists at the National Physical Laboratory (NPL) have mimicked ... genetic material. The research hopes to apply the approach ... defective genes such as those that cause cancer. ... challenges around targeting damaged cells and creating corrective genes. ...
Cached Biology News:In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 2In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 3In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 4Dark beer has more iron than pale beer 2
(Date:9/2/2014)... NC (PRWEB) September 02, 2014 ... of its 11th clinical research site: PMG Research of ... ownership and operation of the clinical research department at ... expanding PMG’s presence in eastern North Carolina. This new ... For the patients in Rocky Mount and the surrounding ...
(Date:9/2/2014)... , September 2, 2014 Culot ... research and lab management services  BioData, producer ... is pleased to announce the appointment of Louis ... recently served as VP Marketing and Business Development at ... research and clinical applications. Previously, Culot worked ...
(Date:9/1/2014)... Reportlinker.com announces that a new market ... India Solid Waste Management Vehicles Market Forecast ... In India ... responsible for complete handling and regulation of solid ... 135,000 MT solid waste is generated daily in ...
(Date:9/1/2014)... 01, 2014 The Collaborative R&D ... report provides comprehensive understanding and unprecedented access to ... by the worlds leading life science companies. , ... of how and why companies enter collaborative R&D ... partner’s negotiated deals terms provides critical insight into ...
Breaking Biology Technology:PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 3Louis Culot Appointed as BioData's CEO 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4
... In the quest to exploit unique properties at ... have developed a novel technique for creating uniform ... and students in the Department of Physics and ... methods from holographic lithography to demonstrate a new ...
... Pharmaceuticals, Inc. (NASDAQ: IDIX ), announced today that ... Stanley Global Healthcare Conference on September 13 at 8:35 a.m. ... the Bank of America Merrill Lynch Global Healthcare Conference on ... of America Merrill Lynch Financial Centre, London.   ...
... Cellectis (Alternext: ALCLS), the French genome engineering specialist, will present at ... September 20, 2011, and at the MidCap Event in Paris on ... will present the activities and the development strategy of the Cellectis ... Hyatt New York hotel on Tuesday, September 20, 2011 at 11:30 ...
Cached Biology Technology:Stevens researchers pioneer novel technique to make plasmonic nanogap arrays 2Stevens researchers pioneer novel technique to make plasmonic nanogap arrays 3
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
Mouse monoclonal [CAT-1] to Chloramphenicol Acetyltransferase ( Abpromise for all tested applications)....
... MaV203 Competent Yeast Cells are designed for ... 1). S. cerevisiae strain MaV203 contains deletions ... for use with GAL4-based two-hybrid systems. The ... for selection of ProQuest bait and prey ...
mCD-1 10 transcription reactions...
Biology Products: