Navigation Links
New biomarker method could increase the number of diagnostic tests for cancer
Date:6/29/2009

f cancer biomarkers are discovered every day, but only a handful ever makes it through clinical validation. This is a critical roadblock because biomarkers have the potential to allow doctors to detect cancer in the earliest stages, when treatment provides the greatest chances of survival," said John E. Niederhuber, M.D., NCI director. "The critical limiting factor to date in validating biomarkers for clinical use has been the lack of standardized technologies and methodologies in the biomarker discovery and validation process, and this research may solve that dilemma."

The collaborative and multi-institute nature of this work was critical because many other technologies have yielded test results that vary greatly from one laboratory to the next. The Clinical Proteomic Technologies for Cancer (CPTC) program was established to help solve this problem. The five institutes that participated in this research as part of the NCI-sponsored CPTAC include the Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Mass.; Vanderbilt-Ingram Cancer Center, Nashville, Tenn.; University of California, San Francisco; Purdue University, West Lafayette, Ind., and Memorial Sloan-Kettering Cancer Center, New York City.

Proteomics studies interactions between proteins, which often work in a tag-team fashion to send important signals within a cell. Most proteomic technologies have been based on mass spectrometry, a decades-old technology that determines which proteins are in a specimen based on the mass and electric charge of fragments of each protein.

The current biomarker discovery process typically identifies hundreds of candidate biomarkers in each study using small numbers of samples, leading to very high rate of invalid biomarkers. The biomarkers that are actually valid -- that is, true biomarkers -- must be culled from lengthy lists of candidates, a time-consuming and not always accurate process.

The CPTAC center
'/>"/>

Contact: Elizabeth Fernandez
efernandez@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. A search for biomarkers for early detection of colorectal cancer
2. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
3. Genetic Engineering & Biotechnology News reports on cancer biomarkers
4. Biomarkers allow doctors to match therapy to patient
5. Biomarker predicts malignancy potential of HG-PIN lesions in the prostate
6. Scientists find potential protein biomarkers for growth hormone
7. Urologists identify 7 biomarkers that may help pinpoint prostate cancer recurrence
8. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
9. Biomarkers for identifying infant infections
10. Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease
11. CHIs 5th Biomarker World Congress: Signature Event with Cutting-Edge Agenda
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and ... addition of the "Global Iris Recognition Market 2015-2019" ... forecast the Global Iris Recognition market to grow at ... This report covers the present scenario and ... for the period 2015-2019. To calculate the market size, ...
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs , ... company, today announced that the Company will demonstrate multiple ... enterprise and consumers at Connect:ID on March 23 through ... HOYOS Labs will highlight the IEEE Biometric Open Protocol ... ; and enterprise access control system. BOPS was invented ...
(Date:3/20/2015)... March 20, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... one of the products featured in 2015 "I Want ... 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 International ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... release is available in German . , FRANKFURT. ... birds may serve as a magnetometer to measure the vector ... only as a magnetic compass, which shows the direction of ... neurobiologists Dr.Gerta Fleissner and her husband Prof. Dr. Gnther Fleissner ...
... Scientists seeking answers to the complex problem of premature birth ... labor, study how genetics and the environment interact to cause ... factors that make some women more likely to give birth ... of Dimes. The March of Dimes has committed ...
... expert survivors of the insect world, appear to lack major ... immune system. "It,s surprising," says Emory biologist Nicole Gerardo, ... Biology . "Aphids have some components of an immune system, ... critical to insect immunity." Pea aphids are major agricultural ...
Cached Biology News:A magnetometer in the upper beak of birds? 2A magnetometer in the upper beak of birds? 3March of Dimes provides $2.6 million in new funding for preterm birth research 2Pesky aphid thrives despite weak immune system 2
(Date:3/25/2015)... 25, 2015 /CNW/ - The Gairdner Foundation is ... Canada Gairdner Awards, recognizing some of the most significant ... Among the world,s most esteemed medical research ... and provide a $100,000 (CDN) prize to each scientist for ... of research and innovation across the country, inspiring ...
(Date:3/25/2015)... -- FDNA®, the pioneer in computer-aided dysmorphology ... allowing geneticists around the globe to access Facial ... devices. Face2Gene® facilitates detection of facial dysmorphic features and ... up-to-date genetic references. The date of the release coincides ... Salt Lake City, UT , where ...
(Date:3/25/2015)... 25, 2015  CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... commercial focus on China , announces ... its target therapy drug candidate ENMD-2076 in triple-negative breast ... of Medical Sciences in Beijing , ...
(Date:3/25/2015)... 2015 Oxis International, Inc. (OXIS) (OXI.PA) a ... announced today Oxis CEO Tony Cataldo will ... at 4:15pm EST to update shareholders and other interested ... Oxis Chairman and CEO Tony Cataldo ... very exciting for Oxis and our shareholders. There is ...
Breaking Biology Technology:2015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 2CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 3CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 4CASI Pharmaceuticals Announces Initiation Of A Phase 2 Trial With ENMD-2076 In Triple-Negative Breast Cancer In China 5Oxis Biotech Inc. Announces Corporate Update Conference Call for March 31 2
... array microscope slide ... scanner in cytogenetic biodosimetry, TUCSON, Ariz., ... digital pathology systems, the Uniformed,Services University of Health Sciences, ... Jackson Foundation for the Advancement,of Military Medicine (HJF) announced ...
... March 11 On Tuesday, April 22,2008, Wyeth (NYSE: ... 2008 first,quarter. The Company will hold a one-hour conference ... April 22, 2008. Interested investors,and others may listen to ... our,Internet webcast, which may be accessed by visiting our ...
... Inc.,(Nasdaq: MAXY ), a biotechnology company focused ... that it will present at the Cowen &,Company ... 18, 2008 at,8:00 a.m. Eastern Time. Russell Howard, ... of the presentation can be accessed on,Maxygen,s website ...
Cached Biology Technology:DMetrix and the Armed Forces Radiobiology Research Institute Announce Cooperative Research and Development Agreement 2DMetrix and the Armed Forces Radiobiology Research Institute Announce Cooperative Research and Development Agreement 3
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
...
... The Thermo Labsystems Wellmix is a ... and time settings. The shaking speed is ... shaking frequency, high speed and a small ... assays. The shaking time is quick and ...
Mouse monoclonal [AZ24] to Polo like kinase ( Abpromise for all tested applications)....
Biology Products: