Navigation Links
New biological scaffold offers promising foundation for engineered tissues
Date:2/24/2014

Our cells don't live in a vacuum. They are surrounded by a complex, nurturing matrix that is essential for many biological functions, including growth and healing.

In all multicellular organisms, including people, cells make their own extracellular matrix. But in the lab, scientists attempting to grow tissue must provide a scaffold for cells to latch onto as they grow and proliferate. This engineered tissue has potential to repair or replace virtually any part of our bodies.

Typically, researchers construct scaffolds from synthetic materials or natural animal or human substances. All have their strengths and weaknesses, but no scaffolds grown in a Petri dish have been able to mimic the highly organized structure of the matrix made by living things, at least until now.

Feng Zhao of Michigan Technological University has persuaded fibroblasts, cells that makes the extracellular matrix, to make just such a well-organized scaffold. Its fibers are a mere 80 nanometers across, similar to fibers in a natural matrix. And, since her scaffold is made by cells, it is composed of the same intricate mix of all-natural proteins and sugars found in the body. Plus, its nanofibers are as highly aligned as freshly combed hair.

The trick was to orient the cells on a nano-grate that guided their growthand the creation of the scaffold.

"The cells did the work," Zhao said. "The material they made is quite uniform, and of course it is completely biological."

Stem cells placed on her scaffold thrived, and it had the added advantage of provoking a very low immune response.

"We think this has great potential," she said. "I think we could use this to engineer softer tissues, like skin, blood vessels and muscle."


'/>"/>
Contact: Marcia Goodrich
mlgoodri@mtu.edu
906-231-5521
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. Unraveling biological networks
2. New method for estimating parameters may boost biological models
3. A project to research biological and chemical aspects of microalgae to fuel approach
4. EPA to highlight innovative ways to detect and respond to biological threats
5. Salk scientists redraw the blueprint of the bodys biological clock
6. Weeding out invasive species with classical biological control
7. Crime and punishment: The neurobiological roots of modern justice
8. Electric charge disorder: A key to biological order?
9. Florida Tech biological sciences professor earns $257,000 NSF grant to study coral diseases
10. Like curry? New biological role identified for compound used in ancient medicine
11. Biological and Pharmaceutical Complex Fluids Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New biological scaffold offers promising foundation for engineered tissues
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... ... May 02, 2016 , ... Meister Media Worldwide launches its ... and added functionality give the agricultural world a taste of Meister Media Worldwide’s ... agriculture – from precision farming via satellites and Unmanned Aerial Vehicles (UAVs) to ...
(Date:5/2/2016)... PA (PRWEB) , ... May 02, 2016 , ... ... proud to report on the pre-launch success of their revolutionary, veterinarian-designed product for ... cats to stalk, trap, and play with their food the way nature intended. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Proove ... excited to announce the launch of the Proove Health Foundation . The ... education to promote the use of personalized medicine for tackling the nation’s most-pressing ...
(Date:4/29/2016)... , April 29, 2016 ... Transparency Market Research "Separation Systems for Commercial Biotechnology ... Trends, and Forecast 2015 - 2023", the separation ... US$ 10,665.5 Mn in 2014 and is projected ... 2015 to 2023 to reach US$ 19,227.8 Mn ...
Breaking Biology Technology: