Navigation Links
New biological scaffold offers promising foundation for engineered tissues
Date:2/24/2014

Our cells don't live in a vacuum. They are surrounded by a complex, nurturing matrix that is essential for many biological functions, including growth and healing.

In all multicellular organisms, including people, cells make their own extracellular matrix. But in the lab, scientists attempting to grow tissue must provide a scaffold for cells to latch onto as they grow and proliferate. This engineered tissue has potential to repair or replace virtually any part of our bodies.

Typically, researchers construct scaffolds from synthetic materials or natural animal or human substances. All have their strengths and weaknesses, but no scaffolds grown in a Petri dish have been able to mimic the highly organized structure of the matrix made by living things, at least until now.

Feng Zhao of Michigan Technological University has persuaded fibroblasts, cells that makes the extracellular matrix, to make just such a well-organized scaffold. Its fibers are a mere 80 nanometers across, similar to fibers in a natural matrix. And, since her scaffold is made by cells, it is composed of the same intricate mix of all-natural proteins and sugars found in the body. Plus, its nanofibers are as highly aligned as freshly combed hair.

The trick was to orient the cells on a nano-grate that guided their growthand the creation of the scaffold.

"The cells did the work," Zhao said. "The material they made is quite uniform, and of course it is completely biological."

Stem cells placed on her scaffold thrived, and it had the added advantage of provoking a very low immune response.

"We think this has great potential," she said. "I think we could use this to engineer softer tissues, like skin, blood vessels and muscle."


'/>"/>
Contact: Marcia Goodrich
mlgoodri@mtu.edu
906-231-5521
Michigan Technological University
Source:Eurekalert  

Page: 1

Related biology news :

1. Unraveling biological networks
2. New method for estimating parameters may boost biological models
3. A project to research biological and chemical aspects of microalgae to fuel approach
4. EPA to highlight innovative ways to detect and respond to biological threats
5. Salk scientists redraw the blueprint of the bodys biological clock
6. Weeding out invasive species with classical biological control
7. Crime and punishment: The neurobiological roots of modern justice
8. Electric charge disorder: A key to biological order?
9. Florida Tech biological sciences professor earns $257,000 NSF grant to study coral diseases
10. Like curry? New biological role identified for compound used in ancient medicine
11. Biological and Pharmaceutical Complex Fluids Conference
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New biological scaffold offers promising foundation for engineered tissues
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/18/2016)... , March 18, 2016 --> ... of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and ... security companies in the border security market and the continuing ... and Europe has led visiongain to ... improved success. --> defence & security companies ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... San Diego, Calif. (PRWEB) , ... May 25, 2016 , ... ... San Diego area and has consistently been rated one of its top attractions. ... over the globe to participate in a unique and intimate team-building experience. , Each ...
(Date:5/25/2016)... Md. (PRWEB) , ... May 25, 2016 , ... ... request for information (RFI) issued by the Office of the National Coordinator for ... patient experience, and determines if clinically relevant data were available when and where ...
(Date:5/25/2016)... ... May 25, 2016 , ... Biohaven Pharmaceutical ... (FDA) has granted the company’s orphan drug designation request covering BHV-4157 for the ... granted by the FDA. , Spinocerebellar ataxia is a rare, debilitating neurodegenerative ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... a newly re-branded identity. The new Media Cybernetics corporate branding reflects a results-driven ... of imaging and image analysis. The re-branding components include a crisp, refreshed logo ...
Breaking Biology Technology: