Navigation Links
New biodegradable compound facilitates bone regeneration in cases of substantial loss
Date:7/30/2010

Bones have a capacity to regenerate themselves after suffering partial damage. However, it is really quite another thing when a serious break or tumour lesion occurs and the loss of tissue is substantial. Today these cases are treated with various kinds of grafts, but they have a number of disadvantages, such as rejection, contamination or limitations on donors.

As a consequence, the current tendency in bone tissue engineering is developing materials that temporarily substitute for the bone while inducing its regeneration in such a way that this, temporary material, disappears as the bone recovers its space. Ms Beatriz Olalde, researcher at the Health Unit of Tecnalia, is working on the creation of one of these compounds. With the results obtained to date, she has presented her PhD thesis at the University of Basque Country (UPV/EHU), entitled, Development of a new porous, biodegradable nanocompound support for the regeneration of bone tissue.

The porous support or foam, developed by Ms Olalde and defended in her thesis, is totally new. The aim was to manufacture a biodegradable porous support which, while temporarily substituting for the damaged bone, would be capable of inducing a process of bone regeneration. With this in mind, a compound was developed which is capable of interacting both chemically and electrically with the bone cells or the adjoining bone tissue, thus accelerating bone recovery.

Polylactic acid, hydroxyapatite and carbon nanotubes

The basis of the composition of the porous support presented in the thesis is a polymer: polylactic acid, a material widely used in medicine and which, given its biodegradable properties, disappears as the bone grows. To this the researcher added a bioceramic hydroxyapatite. Polymers have difficulties in attracting cells and so the function of hydroxyapatite, which provides calcium, is facilitating this integration of the support into the surrounding bone cells.

Finally, the compound also has carbon nanotubes. These enhance the mechanical properties of the polymers, which are limited in this aspect and would otherwise break up given bone resistance. Moreover, it is the carbon nanotubes that provide the electrical character to the porous support, as both the polylactic acid and the hydroxyapatite are insulating materials. In this manner, an electric field can be applied in such a way that the bone cells are directed to the porous support and the regeneration process is accelerated.

According to Ms Olalde in her thesis, the trials undertaken with the new porous support, involving both in vitro and in vivo experiments, gave satisfactory results. The foam proved to have optimum mechanical properties for supporting the bone well and, moreover, it does not break up once implanted. What is more, with the initial in vivo results, obtained 3 weeks alter being implanted in the porous support, bone growth was already observed. Also, after 16 weeks, this new bone showed mechanical, histomorphometric and densitometric properties similar to those of intact or healthy bone tissue.


'/>"/>

Contact: Amaia Portugal
a.portugal@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. Biodegradable particles can bypass mucus, release drugs over time
2. Stanford researchers develop biodegradable substitutes for wood, plastic bottles and other materials
3. Biodegradable mulch films on the horizon
4. Key compound of ozone destruction detected
5. Luteolin stars in study of healthful plant compounds
6. New model is proposed to explain absence of organic compounds on surface of Mars
7. Fluorescent compounds make tumors glow
8. Ontario Cancer Institute, US scientists discover compound that kills lymphoma cells
9. Breathe easy: A natural fruit compound may help asthma
10. Compound screening for drug development made simpler
11. URI pharmacy researcher finds beneficial compounds in pure maple syrup
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), ... published by MarketsandMarkets, the market is expected to be worth USD 18.98 billion ... Continue Reading ... ...      (Logo: ...
Breaking Biology News(10 mins):
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... Lithography Equipment for the Semiconductor, MEMS, and Microfluidics Industries, announces the new Model ... specifications found more often in automated production mask aligners. OAI has already received ...
(Date:8/16/2017)... of Prussia, PA (PRWEB) , ... August 16, 2017 , ... ... will be taking part in sessions at the ISPE Annual Meeting and Expo ... Marriott Marquis San Diego Marina. The event’s theme is “Driving innovation to advance patient ...
(Date:8/16/2017)... ... August 16, 2017 , ... While art and science are often ... connected than one might think. A Mesh Is Also a Snare, a group ... City Science Center’s Esther Klein Gallery (EKG) on August 17 and run through September ...
(Date:8/16/2017)... , Aug. 16, 2017  This year,s edition of the Inc. 5000 ... life sciences workforce solutions, has made the list for the third year ... the nation,s fastest-growing private companies based on a set of quantitative metrics. ... includes the fastest-growing companies in the Bay State . ... Inc. 5000 ...
Breaking Biology Technology: