Navigation Links
New biodegradable compound facilitates bone regeneration in cases of substantial loss
Date:7/30/2010

Bones have a capacity to regenerate themselves after suffering partial damage. However, it is really quite another thing when a serious break or tumour lesion occurs and the loss of tissue is substantial. Today these cases are treated with various kinds of grafts, but they have a number of disadvantages, such as rejection, contamination or limitations on donors.

As a consequence, the current tendency in bone tissue engineering is developing materials that temporarily substitute for the bone while inducing its regeneration in such a way that this, temporary material, disappears as the bone recovers its space. Ms Beatriz Olalde, researcher at the Health Unit of Tecnalia, is working on the creation of one of these compounds. With the results obtained to date, she has presented her PhD thesis at the University of Basque Country (UPV/EHU), entitled, Development of a new porous, biodegradable nanocompound support for the regeneration of bone tissue.

The porous support or foam, developed by Ms Olalde and defended in her thesis, is totally new. The aim was to manufacture a biodegradable porous support which, while temporarily substituting for the damaged bone, would be capable of inducing a process of bone regeneration. With this in mind, a compound was developed which is capable of interacting both chemically and electrically with the bone cells or the adjoining bone tissue, thus accelerating bone recovery.

Polylactic acid, hydroxyapatite and carbon nanotubes

The basis of the composition of the porous support presented in the thesis is a polymer: polylactic acid, a material widely used in medicine and which, given its biodegradable properties, disappears as the bone grows. To this the researcher added a bioceramic hydroxyapatite. Polymers have difficulties in attracting cells and so the function of hydroxyapatite, which provides calcium, is facilitating this integration of the support into the surrounding bone cells.

Finally, the compound also has carbon nanotubes. These enhance the mechanical properties of the polymers, which are limited in this aspect and would otherwise break up given bone resistance. Moreover, it is the carbon nanotubes that provide the electrical character to the porous support, as both the polylactic acid and the hydroxyapatite are insulating materials. In this manner, an electric field can be applied in such a way that the bone cells are directed to the porous support and the regeneration process is accelerated.

According to Ms Olalde in her thesis, the trials undertaken with the new porous support, involving both in vitro and in vivo experiments, gave satisfactory results. The foam proved to have optimum mechanical properties for supporting the bone well and, moreover, it does not break up once implanted. What is more, with the initial in vivo results, obtained 3 weeks alter being implanted in the porous support, bone growth was already observed. Also, after 16 weeks, this new bone showed mechanical, histomorphometric and densitometric properties similar to those of intact or healthy bone tissue.


'/>"/>

Contact: Amaia Portugal
a.portugal@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. Biodegradable particles can bypass mucus, release drugs over time
2. Stanford researchers develop biodegradable substitutes for wood, plastic bottles and other materials
3. Biodegradable mulch films on the horizon
4. Key compound of ozone destruction detected
5. Luteolin stars in study of healthful plant compounds
6. New model is proposed to explain absence of organic compounds on surface of Mars
7. Fluorescent compounds make tumors glow
8. Ontario Cancer Institute, US scientists discover compound that kills lymphoma cells
9. Breathe easy: A natural fruit compound may help asthma
10. Compound screening for drug development made simpler
11. URI pharmacy researcher finds beneficial compounds in pure maple syrup
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: