Navigation Links
New bacterial signaling molecule could lead to improved vaccines
Date:5/27/2010

Many disease-causing microbes carry pumps that expel antibiotics, making the bugs hard to kill with standard drugs.

Ironically, these same pumps could be the bugs' Achilles heel.

University of California, Berkeley, scientists have found that the molecular pumps in Listeria bacteria, and perhaps in other pathogens, also expel small signaling molecules that stimulate a strong immune response in the cells they infect. A robust immune response, involving mobilization of killer cells and a host of other defenses, is needed to kill bad microbes before they can do damage

The surprising find that bacteria pump out a totally new and highly immunogenic molecule suggests that it may be possible to improve vaccines that use live or disabled bacteria to activate the immune system. These vaccine-grade bacteria could be engineered to ramp up production of the signaling molecule or ramp up the number of pumps, for example.

"We think this could translate directly into better vaccines," said Daniel Portnoy, UC Berkeley professor of molecular and cell biology and of public health and associate faculty director of the campus's Center for Emerging and Neglected Diseases. "We can certainly get Listeria bacteria to make more of this molecule; we already have a mutant that does that."

The researchers report their discovery, funded in part by the American Recovery and Reinvestment Act (ARRA) through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, in the May 28 issue of the journal Science.

For more than 20 years, Portnoy has been studying Listeria monocytogenes bacteria, which cause the serious foodborne illness listeriosis, to understand how they generate an unusually strong immune response in host cells. What he learns could help boost the effectiveness of a Listeria vaccine, but he also hopes to use the bacteria's powerful immunogenicity to boost the effectiveness of vaccine
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Legionnaires bacterial proteins work together to survive
2. Scripps research team blocks bacterial communication system to prevent deadly staph infections
3. Small RNA plays parallel roles in bacterial metabolism
4. New drug targets may fight tuberculosis and other bacterial infections in novel way
5. Bacterial infections in premature babies more common than previously realized
6. Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture
7. Biochemists reveal details of mysterious bacterial microcompartments
8. Biologists surprised to find parochial bacterial viruses
9. Tomato pathogen genome may offer clues about bacterial evolution
10. Bacterial slime helps cause serious disease
11. A survivor in Greenland: A novel bacterial species is found trapped in 120,000-year-old ice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2015 In the current ... outperforms the strongest competitors, showing outstanding performance in ... system is capable of a throughput of 5.000.000 ... to be ten times faster than most competitors ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) ...
(Date:4/1/2015)... 2015   Medisafe ™, the leading global medication ... iOS and Android smartphones and tablets, ... the platform to allow patients to track and correlate ... time, patients will be able to visualize in real-time ... biometrics, such as glucose levels and blood pressure. ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... This release is available in German . ... that Nadja Knoll found new proof in the nomad people of ... nutritionist from the Friedrich Schiller University Jena (Germany) analyzed the diet ... of the field study show that the Maasai are in a ...
... PROVIDENCE, R.I. [Brown University] In 1988, a mysterious invader ... likely arrived in ballast from commercial ships, and it found ... decades later, the crab, Hemigrapsus sanguineus , has expanded ... southward to North Carolina. Its numbers continue to expand, and ...
... ORLEANS, LA Broncus Technologies, Inc., a medical device ... diseases, announced today at the American Thoracic Society ... system version 2.1. The bronchoscopic navigation system is ... These highlight the clinical benefits of using the ...
Cached Biology News:Nomad people baffle with good health in spite of malnourishment 2Are invasives bad? Not always, say Brown researchers 2LungPoint system results presented at American Thoracic Society 2010 International Conference 2LungPoint system results presented at American Thoracic Society 2010 International Conference 3
(Date:5/1/2015)... Investor-Edge has initiated coverage ... GENE ), Agilent Technologies Inc. (NYSE: ... TMO ), Sequenom Inc. (NASDAQ: SQNM ), ... research report on Genetic Technologies can be accessed ... 2015, the NASDAQ Composite ended at 4,941.42, down ...
(Date:4/30/2015)... , April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of foodborne ... the first quarter of 2015 on May 7, 2015 ... Roka Bioscience will also host a conference call at ... discuss its first quarter financial results. During the conference ...
(Date:4/30/2015)... 30, 2015 Oxford Finance LLC ("Oxford"), a ... sciences and healthcare services companies, today announced the closing ... with Celula, Inc., a diagnostic testing company focused on ... patient care and improved outcomes.  Proceeds of the loan ... the commercialization of its products in the U.S. and ...
(Date:4/30/2015)... MENLO PARK, Calif. , April 30, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... operating results on Thursday, May 7, 2015 after the ... host a conference call and webcast on Thursday, May ... Pacific to discuss the results and recent corporate developments. ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Oxford Finance Provides $10 Million Debt Financing to Celula 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3
... the late 1970s with the first IPOs taking place in 1980 ... 25 years old. , ,An interesting article in Genetic Engineering ... most industry cycles run about 50 years until they mature. If ... cycle. A new industry of significance usually produces an industrial revolution, ...
... the Digital Healthcare Conference 2005 on choosing ... technology. , ,For the Froedtert & Medical College ... other systems is simply one way, albeit a powerful ... ,"Research is our mission, and technology can help us ...
... Wis. Representatives of the British Consulate-General, ... health technology investments, met Wisconsin companies on Tuesday ... , ,"We're looking for companies with complimentary products ... for the Chicago office of the British ...
Cached Biology Technology:Biotech industry reaches midpoint in 50-year maturation cycle 2Biotech industry reaches midpoint in 50-year maturation cycle 3Biotech industry reaches midpoint in 50-year maturation cycle 4Biotech industry reaches midpoint in 50-year maturation cycle 5Rodney Dykehouse of Froedtert and Medical College of Wisconsin warns against tech for its own sake 2Rodney Dykehouse of Froedtert and Medical College of Wisconsin warns against tech for its own sake 3British, Wisconsin firms explore life-science opportunities together 2British, Wisconsin firms explore life-science opportunities together 3
Mouse monoclonal [HL-37] to HLA DQ1 + HLA DQ3 ( Abpromise for all tested applications)....
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
... Features Convenient platform for tube handling and ... x 0.2ml V-bottom tubes - 96 ... - Thermo-Fast® 96 Non-Skirted Plate ... - 48 x 0.5ml Thermo-Tubes Multiple workstations can ...
6B9...
Biology Products: