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New bacteria-resistant materials discovered
Date:8/13/2012

Using state-of-the-art technology scientists at The University of Nottingham have discovered a new class of polymers that are resistant to bacterial attachment. These new materials could lead to a significant reduction in hospital infections and medical device failures.

Medical device associated infections can lead to systemic infections or device failure, costing the NHS 1bn a year. Affecting many commonly used devices including urinary and venous catheters bacteria form communities known as biofilms. This 'strength in numbers approach' protects them against the bodies' natural defences and antibiotics.

Experts in the Schools of Pharmacy and Molecular Medical Sciences, have shown that when the new materials are applied to the surface of medical devices they repel bacteria and prevent them forming biofilms.

The research was led by Professor Morgan Alexander, and Professor Martyn Davies in the School of Pharmacy and Professor Paul Williams in the School of Molecular Medical Sciences. The results of the 1.3m four year research project supported by a Translation Award from the Wellcome Trust, have been published today, Sunday 12 August 2012, in the prestigious academic journal Nature Biotechnology.

The novel materials had to be found using a new technique

Researchers believed there were new materials that could resist bacteria better but they had to find them. This meant screening thousands of different chemistries and testing their reaction to bacteria a challenge which was beyond conventional materials development or any of our current understanding of the interaction of micro-organisms with surfaces.

The discovery has been made with the help of experts from the Massachusetts Institute of Technology (MIT) who initially developed the process by which thousands of unique polymers can now be screened simultaneously.

Professor Alexander said: "This is a major scientific breakthrough
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Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-115-951-5751
University of Nottingham
Source:Eurekalert  

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