Navigation Links
New autism research reveals brain differences at 6 months in infants who develop autism
Date:2/17/2012

PHILADELPHIA, PA − A new study from the Infant Brain Imaging Network, which includes researchers at the Center for Autism Research at the Children's Hospital of Philadelphia (CHOP), found significant differences in brain development starting at age 6 months in high-risk infants who later develop autism, compared to high-risk infants who did not develop autism.

"It's a tremendously exciting finding," said Sarah Paterson, PhD, director of the Infant Neuroimaging Lab at CHOP's Center for Autism Research. "We found that the brains of the children who developed autism were markedly different even prior to the onset of behavioral symptoms of autism. Thus, our findings, while requiring replication, are a very important first step towards identifying a biomarker for autism risk. This would enable specialists to diagnose autism much earlier than what is currently possible through behavioral observations."

The study also suggests that autism does not appear suddenly in young children but instead develops over time during infancy, note the authors. Intensive early intervention has been shown to improve outcomes in children with developmental delays and autism.

"This research raises the possibility that we might be able to intervene even before a child is 6 months old, to blunt or prevent the development of some autism symptoms," said Paterson.

The study was published February 17th in the American Journal of Psychiatry. Its results are the latest from the ongoing Infant Brain Imaging Study (IBIS), which is led at CHOP by Dr. Paterson and Robert Schultz, PhD, who are co-authors on this study.

Participants in the study were 92 infants considered to be at high risk for ASD, because they all have older siblings with autism. Each infant had diffusion tensor imaging (DTI) a type of magnetic resonance imaging (MRI) at 6 months and behavioral assessments at 24 months. Most of the children also had additional brain imaging scans at either or both 12 and 24 months.

At 24 months, 28 infants (30 percent) met criteria for ASDs while 64 infants (70 percent) did not. The two groups differed in white matter fiber tract development pathways that connect brain regions as measured by fractional anisotropy (FA). FA measures white matter organization and development, based on the movement of water molecules through brain tissue.

This study examined 15 separate fiber tracts, and found significant differences in FA growth trajectories in 12 of the 15 tracts between infants who did develop autism versus infants who did not. Infants who later developed autism had elevated FA at six months but then experienced slower development over time. By 24 months of age, infants with autism had lower FA values than infants without autism.

The findings come on the heels of a recent study from London published in Current Biology, which found that infants at high risk for autism who were later diagnosed with the condition showed different brain responses from low-risk babies, or from high-risk babies that did not develop autism when shown images of faces looking at or away from the baby. Paterson said that the two findings strengthen one another and are encouraging evidence that scientists are on the right track towards finding markers for identifying autism much earlier than is currently possible.


'/>"/>
Contact: Dana Mortensen
mortensen@email.chop.edu
267-426-6092
Children's Hospital of Philadelphia
Source:Eurekalert

Related biology news :

1. Brain-imaging differences evident at 6 months in infants who develop autism
2. Study looks at possible link to hyper-excitability factors in epilepsy, autism and more
3. Autism experts to gather at USC symposium
4. A clue to the GI problems that plague many kids with autism?
5. Autism may be linked to abnormal immune system characteristics and novel protein fragment
6. Neurons grown from skin cells may hold clues to autism
7. Diagnoses of autism spectrum disorders vary widely across clinics
8. UMMS researchers identify epigenetic signatures of autism
9. New findings validate the accuracy of autism diagnosis in children with Down syndrome
10. Study finds promising drug treatment for improving language, social function in people with autism
11. Children with autism benefit from early, intensive therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/21/2016)... 2016 Unique technology combines ... superior security   Xura, Inc. ... secure digital communications services, today announced it is working ... enterprise customers, particularly those in the Financial Services Sector, ... authentication within a mobile app, alongside, and in combination ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... Boston, MA (PRWEB) , ... April 28, 2016 ... ... (EDT), Asymmetrex will deliver a talk on its first-in-class technologies for ... the 2016 Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome ...
(Date:4/27/2016)... ... April 27, 2016 , ... Shimadzu Scientific Instruments ... Spring 2016 Marijuana Business Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to ... more. Expo attendees can stop by booth 1021 to learn how Shimadzu’s instruments ...
(Date:4/27/2016)... RESEARCH TRIANGLE PARK, N.C. , April ... UTHR ) announced today that Martine Rothblatt , ... will provide an overview and update on the company,s ... Health Care Conference. The presentation will take ... Eastern Time, and can be accessed via a live ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI ... testing novel treatments in small animal subjects. Simultaneous PET/MRI imaging offers a solution ...
Breaking Biology Technology: