Navigation Links
New approach to treating human brain cancer could lead to improved outcomes
Date:9/25/2013

f the SHH pathway that regulate cell growth during normal development. The mutations cause cell signaling to go awry, triggering the creation of cancer cells that grow uncontrollably and establish tumors. SHH-associated tumors account for 25 percent of all human cases of medulloblastoma, and the SHH pathway has been implicated in other tumor types such as lung, breast, prostate, and skin cancer.

"Our increased understanding of SHH-associated tumors has recently led to the development of drugs that specifically inhibit the SHH pathway. Early studies in humans with these new drugs have offered some hope for patients, but many do not respond and most patients who do respond develop resistance to the drug. For this reason, it is essential to develop alternative, or additional, therapies that are more effective than current treatment options," Wechsler-Reya said.

The team's first set of experiments used a mouse model for SHH-dependent medulloblastoma. In-vitro studies of mouse tumor cells showed that cell-cycle inhibitors caused tumor cell death. In vivo, mice that were treated with the inhibitor had smaller tumors that weighed less compared to mice that were not treated, essentially halting the progression of the tumor.

The second set of experiments used human SHH-dependent medulloblastoma cells. When the researchers treated these human tumor cells with cell-cycle inhibitors, they also observed a significant reduction in tumor growth and progression.

Finally, when the scientists combined SHH inhibitors with cell-cycle inhibitors, they found that the combination worked together to produce results that were greater than either inhibitor alone.

"These results strongly support an approach to treatment that combines SHH inhibitors with cell-cycle inhibitors to treat medulloblastoma. Our hope is that the combination of these inhibitors will prevent tumor progression and drug resistance, and improve the overall effectiveness of curr
'/>"/>

Contact: Susan Gammon, Ph.D.
sgammon@sanfordburnham.org
310-610-3808
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A new approach to early diagnosis of influenza
2. Novel approach to gene regulation can activate multiple genes simultaneously
3. Mechanism offers promising new approach for harnessing the immune system to fight cancer
4. Study highlights possible new approach to prostate cancer treatment
5. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
6. New approach to protecting prion protein from altering shape
7. New data support community-wide approach to addressing child obesity
8. A Future-Proof Approach to Intelligent Buildings
9. New chemical approach to treat Alzheimers
10. Agencies should use common approach to evaluate risks pesticides pose to endangered species
11. Novel therapeutic approaches to cure chronic HBV infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... , and HILDEN, Germany , June ... QGEN ; Frankfurt Prime Standard: QIA) today launched new Investigator ... in forensic laboratories in the United States ... to simultaneously analyze multiple key genomic markers (short tandem repeats ... Quality Sensor to evaluate the quality of DNA in ...
(Date:6/16/2015)... Fingerprint Cards has received an order ... company,s portfolio from one of its module partners in ... place during the third quarter 2015. The sensors will be ... Jörgen Lantto, CEO of FPC, comments: " This ... interest from smartphone OEMs in integrating touch fingerprint sensors in ...
(Date:6/12/2015)... DALLAS , June 12, 2015  Securus ... justice technology solutions for public safety, investigation, corrections ... issued its patent to electronically capture, analyze and ... various facial recognition methods. This system ... authorized by an enrollment and subsequent sign-on process ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2
... mice responsible for repairing DNA strands damaged by oxidation ... that such stress contributes to the development of cancer. ... DNA Repair by researchers at the National Institute ... University (OHSU) and the New York University School of ...
... measure organic contaminants in human body fluids, the National ... four new Standard Reference Materials (SRMs) available for purchase. ... and Prevention (CDC), the human milk and serum SRMs ... pesticides, commonly found in the U.S. population. Scientists at ...
... Netherlands: For the first time, researchers have been able ... of IVF treatment in blood. Dr. Cathy Allen, from the ... the European Society of Human Reproduction and Embryology today (Wednesday ... works for some patients but not for others. Previous ...
Cached Biology News:Genetically engineered mice yield clues to 'knocking out' cancer 2NIST issues human milk and blood serum SRMs for contaminant measurements 2Will IVF work for a particular patient? The answer may be found in her blood 2Will IVF work for a particular patient? The answer may be found in her blood 3
(Date:7/2/2015)... , July 2, 2015 Amici ... Bio-tech procurement company Amici Procurement has chosen Microsoft Cloud ... it move to Office 365.      (Logo: ... small to medium-sized companies in the bio-tech sector with ... of the purchasing cycle to help them obtain best ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... development and manufacturing of surgical instruments in Orthopedics, announced today the acquisition of ... and the world's largest provider of surgical instruments to the Spine Industry. The ...
(Date:7/1/2015)... PARIS , July 1, 2015 ... key developer of biotech crops, today announce a ... generations of insect control traits. "Growers ... the realities of advancing insect resistance. We are ... insect control technology with Genective,s capability in developing ...
(Date:7/1/2015)... ... July 01, 2015 , ... The next-generation sequencing (NGS) ... market segments, including the molecular diagnostics industry. BCC Research reveals in its new report ... tests, lower test costs, and a growing need for better diagnostics as part of ...
Breaking Biology Technology:Biotech Procurement Company Moves to Office 365 with iomart 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3AgBiome and Genective collaborate to create novel insect-resistant crops 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3
... September 10 Elsevier,a leading publisher of scientific, technical ... become one of the Charter Members of the,InChI Trust ... the first InChI Trust Board,meeting on September 11th. , ... Union of Pure and Applied,Chemistry (IUPAC), the IUPAC International ...
... , ROTTERDAM, The Netherlands, September 10 ... development of human,antibodies using its proprietary SIMPLE Antibody(TM) platform, today,announced ... The Company raised EUR 9.5million ( USD 13.6 million) from ... one of,the largest of its kind in the last 12 ...
... James Tour have brought graphite,s potential as a mass ... created the potential for reprogrammable gate arrays that could ... In a paper published in the online ... Alexander Sinitskii show how they,ve used industry-standard lithographic techniques ...
Cached Biology Technology:Elsevier Joins InChI Trust as a Charter Member 2Elsevier Joins InChI Trust as a Charter Member 3Elsevier Joins InChI Trust as a Charter Member 4arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 2arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 3arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 4arGEN-X Raises EUR9.5 Million to put SIMPLE Antibody(TM) Platform to Work 5Graphitic memory techniques advance at Rice 2Graphitic memory techniques advance at Rice 3
... is a fully licensed, high throughput, water bath ... up to 24 microplates. This equates to 9,216 ... ,A robotic arm rapidly transfers a basket of ... ramping times that are considerably faster than those ...
... Ribonuclease is a 27kDa periplasmic enzyme from ... RNA to cyclic nucleotide monophosphate (NMP) intermediates. ... these intermediates to 3-NMPs (1). RNase ONE ... RNases that can cleave a phosophodiester bond ...
... to Dideoxycytidine Dideoxycytidine is a cytidine analog ... inhibiting retroviral activity. Immunogen: Chemical ... Specificity: The specificity of the ddC antiserum ... moles of ddC to moles of ddC analog ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
Biology Products: