Navigation Links
New approach to protecting prion protein from altering shape
Date:7/18/2013

ed them with Creutzfeldt-Jakob disease prions. The mice did eventually develop symptoms, but the signs did not emerge for more than a year in fact, it took about 400 days. In contrast, mice without the modified prion protein showed symptoms within 260 days.

"Our discovery that a tailor-made mutation in one specific region of prion protein can prevent it from changing shape to a disease-associated conformation helps resolve the ongoing major controversy in the field regarding the mechanism by which infectious prions self-replicate," said Qingzhong Kong, PhD, associate professor of pathology and first author on the paper.

With no effective treatments currently available for these fatal diseases, this finding has also important implications for the development of new drugs. It suggests a novel pharmacologic strategy in which scientists can either identify or design a molecule that binds to prion protein and stabilizes its normal shape, thereby preventing propagation of the disease.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New data support community-wide approach to addressing child obesity
2. A Future-Proof Approach to Intelligent Buildings
3. New chemical approach to treat Alzheimers
4. Agencies should use common approach to evaluate risks pesticides pose to endangered species
5. Novel therapeutic approaches to cure chronic HBV infection
6. BUSM researchers identify novel approach to study COPD and treatment efficacy
7. Vitamin P as a potential approach for the treatment of damaged motor neurons
8. Einstein study reveals new approach for stopping herpes infections
9. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
10. New approaches for controlling pesticide exposure in children
11. New approach alters malaria maps
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Researchers who studied 100 twin pairs have identified a gene ... less than six hours of sleep per night. The ... effects of sleep deprivation. , Results show that a participant ... had an average nightly sleep duration of only five hours, ... twin, who slept for about six hours and five minutes ...
(Date:7/31/2014)... France, and the U.S. has discovered and described ... member of the tribe Omaliini that has ever ... were made possible through the use of the ... the detailed study of otherwise invisible specimens in ... the journal Annals of the Entomological Society ...
(Date:7/31/2014)... loud noise alters how the brain processes speech, ... according to neuroscientists at The University of Texas ... week in Ear and Hearing , researchers ... loss affects the brain,s recognition of speech sounds. ... of the population, affecting an estimated 15 percent ...
Breaking Biology News(10 mins):Study of twins discovers gene mutation linked to short sleep duration 2UT Dallas study reveals effect of loud noises on brain 2
... (November 28, 2012) Tufts University School of Engineering ... offer significant improvement in tissue imaging while simultaneously ... monitoring drug delivery. The devices also lend themselves ... Biodegradable and biocompatible, these tiny mirror-like devices ...
... a drop of water forms on a pine needle, rolls down ... repeated over and over, on each pine needle of every tree ... the coast of Santa Barbara. That fog drip helps the entire ... and wetter times, Bishop pine trees are thought to have proliferated ...
... silk is one of the strongest materials known: Research by ... from silk,s unusual hierarchical arrangement of protein building blocks. ... and Joyce Wong of Boston University has synthesized new ... making further improvements in the synthetic material. And an ...
Cached Biology News:Implantable silk optics multi-task in the body 2New study shows how climate change could affect entire forest ecosystems 2New study shows how climate change could affect entire forest ecosystems 3New study shows how climate change could affect entire forest ecosystems 4The music of the silks 2The music of the silks 3
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... bearings are uniquely suited to prevent loss of lubrication ... the high temperatures . , Recently, a manufacturer ... engineers at Graphite Metallizing to overcome problems with movement ... operation, pans containing blocks of powder mixture are loaded ...
(Date:7/31/2014)... July 31, 2014 According to ... "Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, ... - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - ... 2013 - 2019," the global electrodes market for medical ... and is estimated to reach a market worth USD ...
(Date:7/31/2014)... California (PRWEB) July 31, 2014 CollabRx, ... that inform therapeutic decision-making in oncology, today announced that ... 14, 2014 to discuss the Company's financial results for ... an update about the business in the current fiscal ... call beginning on Thursday, August 14, 2014, at 5 ...
(Date:7/31/2014)...  Smith & Nephew (LSE:SN, NYSE: ... announced its entry into the forefoot market with ... System. Comprised of three separate repair options, the ... repair and reconstruction, a metatarsal osteotomy guide, and ... fusion, also known as hammer toe correction. ...
Breaking Biology Technology:Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4
... in Latin,America, WASHINGTON, June 12 The ... San Francisco (UCSF) announced,today that 10 promising biomedical ... in the Biomedical Sciences. Funded by Pew through ... offers talented,young Latin American scientists $60,000 for a ...
... today the,results of tests utilizing its Ygiene(TM) formulation ... is designed to be used by the,military and ... "The Ygiene(TM) formulation killed all anthrax spores exposed ... said Dr. Philip Tierno, the,Principal Investigator on the ...
... Company Begins Process to Restore Shareholder Value Following NEBIDO(R) ... ... Indevus,Pharmaceuticals, Inc. (Nasdaq: IDEV ) today announced that Glenn L. Cooper,MD, ... the Company through the challenges,it faces as a result of the recent ...
Cached Biology Technology:Ten Latin American Scientists Named 2008 Pew Fellows in the Biomedical Sciences 2BioNeutral Announces a BREAKTHROUGH in the Fight Against Bioterrorism 2Indevus Announces Management Changes 2Indevus Announces Management Changes 3Indevus Announces Management Changes 4