Navigation Links
New approach to protecting prion protein from altering shape
Date:7/18/2013

A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for neurodegenerative diseases. This finding, published in the July 18 issue of Cell Reports, offers new hope in the battle against a foe that until now has always proved fatal.

Prion diseases include Creuzfeldt-Jakob disease and fatal familial insomnia. Unlike other transmissible diseases, the infectious agent is not a virus or bacteria, but an abnormally shaped prion protein. Scientists believe it self-replicates by binding to normal prion proteins and forcing them to change shape to become an abnormal, and thus diseased, protein.

"Once heretical, the notion that proteins alone can act as self-propagating infectious agent is now becoming accepted as a new paradigm in biology and medicine. However, the mechanism by which prion protein changes its shape remains largely unknown and highly controversial, hindering efforts to develop drugs for prion diseases," said Witold Surewicz, PhD, professor of physiology and biophysics and senior author of the study. "A heated debate continues as to which part of the prion protein undergoes the change and what is the three-dimensional structure of the infectious form of the protein."

The researchers generated a variant of prion protein designed to stabilize the normal shape of one specific part of the protein. They accomplished this goal by replacing just one out of more than 200 amino acid residues, the building blocks of the protein. In a series of experiments, the researchers found that the modified prion protein was highly resistant to changing its shape. In other words, this approach may be successful in blocking the coercive action of the abnormal prion protein.

The team then created transgenic mice that produced this "superstable" human prion protein and infect
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New data support community-wide approach to addressing child obesity
2. A Future-Proof Approach to Intelligent Buildings
3. New chemical approach to treat Alzheimers
4. Agencies should use common approach to evaluate risks pesticides pose to endangered species
5. Novel therapeutic approaches to cure chronic HBV infection
6. BUSM researchers identify novel approach to study COPD and treatment efficacy
7. Vitamin P as a potential approach for the treatment of damaged motor neurons
8. Einstein study reveals new approach for stopping herpes infections
9. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
10. New approaches for controlling pesticide exposure in children
11. New approach alters malaria maps
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... news release is available in German . ... as individuals prompt our fellow humans to behave socially? ... social dilemmas in game theory. Previous studies assumed that ... groups. Nonetheless, scientists from the Max Planck Institute for ... can exert an influence on the cooperative behaviour of ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... oil and gas production are well over recommended levels ... access journal Environmental Health . High levels of ... is the first to be based on community sampling ... be used to supplement official air-quality monitoring programs. , ... not readily flow to the surface. This is because ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4New tech aims to improve communication between dogs and humans 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
... not all plants from the same species can be ... only prevent the exchange of genes between well-established species ... but also between varieties of one and the same ... if one wants to understand the origin of biodiversity. ...
... global inventory of farm animals showing many breeds of ... extinction, scientists from the Consultative Group on International Agricultural ... genebanks to conserve the sperm and ovaries of key ... An over-reliance on just a few breeds of ...
... clear nearly a century ago that many genes likely influence ... has followed in defining the myriad genes. Now an international ... a genetic variant associated with human height the first ... in the September 2 advance online edition of Nature Genetics, ...
Cached Biology News:How the plant immune system can drive the formation of new species 2How the plant immune system can drive the formation of new species 3Report: African, Asian, Latin American farm animals face extinction 2Report: African, Asian, Latin American farm animals face extinction 3Report: African, Asian, Latin American farm animals face extinction 4Genome study shines light on genetic link to height 2Genome study shines light on genetic link to height 3
(Date:10/30/2014)... 2014  Ardelyx, Inc. (NASDAQ: ARDX ... gastrointestinal and metabolic diseases, today announced that it ... Thursday, November 6, 2014. Following the announcement, the ... call and webcast at 4:30pm ET to review ... update. The live webcast can be ...
(Date:10/30/2014)... 30, 2014 SoundConnect , ... offers Office 365 end users the key to ... phone system by adding voice enablement and hybrid ... Lync Online, a communication tool that includes presence, ... hosted voice, O365 becomes a comprehensive unified communications ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Whitehouse Laboratories ... its ICH Stability Testing and Package Test Capacity. Responding ... centers on a dramatic increase in environmental chamber storage ... stability, storage and aging samples to be securely held ... this major capital expenditure has already taken place with ...
(Date:10/30/2014)... A new report, commissioned by BioCrossroads and ... in-depth look at Indiana,s capital ... two different time frames: 1993 to 2002 and 2003 ... opportunities for investment growth.  The Life Science Innovation ... gains in innovation dollars as well as an increase ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5
... 18 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: ... specializing in the manufacture,research, development, marketing and ... applied for listing approval on the Nasdaq ... milestone for China-Biotics, and we are committed,to ...
... 18 Swedish environmental technology,company SEKAB has signed ... its sustainability with LDC Bioenergia, a Brazilian ethanol,and ... group Louis Dreyfus., "The agreement safeguards supplies ... production chain for environmental and social,sustainability," says Anders ...
... a magnet that,s smaller than the head of a pin? ... of MRI technique to do just that. , The technique may ... doctors a new tool for studying the plaques in blood vessels ... In a recent issue of Physical Review Letters, the ...
Cached Biology Technology:China-Biotics, Inc. Files Application for Nasdaq Listing 2SEKAB Agreement: More Verified Ethanol to Europe 2New kind of MRI enables study of magnets for computer memory 2New kind of MRI enables study of magnets for computer memory 3
... harvesting of cells • Blade design minimizes ... the growth surface • Designed for use ... wrapped • Sterilized by gamma radiation and ... a new product number, created to easily ...
... single use spatulas have been designed to ... are for those interested in eliminating the ... Each spatula is individually packaged, RNase/DNase free, ... is a new product number, created to ...
... use with dishes and cell culture clusters. ... product number, created to easily match Cornings ... please order under the old Sigma-Aldrich number ... Comp Dim: blade L 1.9 cm handle ...
... interferons are cytopathic effect inhibition assays, also ... The neutralization assay measures the antibody's ability ... cytokine. Sample types include; tissue culture supernatents; ... assays, one unit is defined as the ...
Biology Products: