Navigation Links
New approach for tuberculosis drugs
Date:7/2/2014

Consumption was one of the worst known diseases of the 18th century. Thanks to medical advances, the number of deaths from this lung disease which is today known as tuberculosis has declined significantly. Efforts to eradicate the disease in the 1950s and 1960s resulted in a wide range of new drugs entering the market.

And yet 1.4 million people still continue to die each year from tuberculosis. Multidrug-resistant strains of the disease-causing pathogen are especially dangerous because they can no longer be treated with today's drugs (see box). "In the past 50 years, only one new tuberculosis drug has come on to the market, and that was in 2012," says Karl-Heinz Altmann, Professor of Pharmaceutical Biology at ETH Zurich. New active substances that are able to kill multidrug-resistant strains of the disease are therefore urgently needed. Altmann and his team have now laid the foundation for new tuberculosis drugs, and they were inspired by a bacteria-derived antibiotic called pyridomycin.

New design for greater efficacy

Pyridomycin inhibits the growth of the tuberculosis pathogen Mycobacterium tuberculosis, but it is degraded relatively quickly and is therefore ineffective. However, by using the structure of pyridomycin, Altmann and his research group have designed a molecule that has several advantages over the natural active substance. The new molecule is more stable and is easier to produce synthetically; it can also serve as a lead structure for the synthesis and biological testing of further modified versions of the active substance. Drugs could eventually be developed that work efficiently and are well tolerated. They could also be be adapted such as to overcome new drug-resistant strains of the tuberculosis pathogen. The researchers have applied for a patent for the new active substance's basic structure and the method of production.

The researchers found inspiration from a long forgotten subs
'/>"/>

Contact: News & Media Relations
mediarelations@hk.ethz.ch
41-446-324-141
ETH Zurich
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. A project to research biological and chemical aspects of microalgae to fuel approach
3. UofL research holds promise of therapeutic approach for gum disease
4. Approach to diabetes self-management too narrow, study suggests
5. Manatee hearing good enough to sense approaching motorboats
6. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
7. New approach to spell checking gene sequences
8. Powerful new approach to attack flu virus
9. Potential new approach to regenerating skeletal muscle tissue
10. Bugs have key role in farming approach to storing CO2 emissions
11. Computing advances vital to sustainability efforts; new report recommends problem-focused, iterative approach to research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , a ... will showcase its EyeLock ID technology integrated in a 3D ... Oak Ridge National Laboratory (ORNL) at the 2015 ... authentication technology is being used to validate the driver and ...
(Date:1/22/2015)... , Jan. 16, 2015  A man-made form of ... and other mental capabilities in adults with mild cognitive ... study led by researchers at Wake Forest Baptist Medical ... diagnosed with amnesic mild cognitive impairment (MCI) or mild ...
(Date:1/22/2015)... YORK and POINT ROBERTS, Washington ... news source covering leading sectors including technology and tech stocks, ... Privacy marketplace featuring master pickpocket and security consultant Apollo ... is stolen and talks about the Wocket™ biometric smart wallet, ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... Great Lakes with things like trout and salmon would be good ... water, so it would be natural to assume that more fish ... the April journal of Ecology by the Ecological Society of America ... trout to the area has not been good for the birds, ...
... experts on evolution will gather in Minnesota June 20 ... gathering of evolutionary biologists. The conference, the premier international ... is sponsored by the University of Minnesota,s Bell Museum ... and Minnesota Citizens for Science Education. Headlining the ...
... and Micaela Caramellino, two doctoral students in ... at a student poster event organized for developing ... micro-sized drug particles. The New Jersey section of ... sponsor. In recent years, the pharmaceutical ...
Cached Biology News:Restoring fish populations leads to tough choice for Great Lakes Gulls 2University of Minnesota to host world's largest conference on evolution 2NJIT doctoral students receive recognition at poster competition 2
(Date:2/26/2015)... The Pittcon 2015 Exposition, which takes ... Morial Convention Center in New Orleans, Louisiana, will ... 2015) displaying products and services used by the ... The Exposition will offer the latest innovations in ... chemistry; drug discovery; nanotechnology; life sciences to include ...
(Date:2/26/2015)... February 26, 2015 Innovation is ... emerging from unexpected parts of the world and ... From agriculture to manufacturing to health care, disruption ... environmental realities and socio-political trends shake the foundations ... key ingredient for CEOs to survive the next ...
(Date:2/26/2015)... 26, 2015 According to a new ... Market For Transgenic Crops (Corn, Soybean, Cotton and Others), ... Size, Share, Growth, Trends and Forecast, 2013 – 2019,”the ... million in 2012 and is expected to reach USD ... 9.5% from 2013 to 2019. , Demand for ...
(Date:2/26/2015)... 2015 Regis Technologies announced new ... oncology drug substances. , Regis Technologies is proud to ... Potent Compound Suite (PCS) for 2015. , Regis is ... cGMP facility in Morton Grove, Illinois. The PCS addition ... compounds up to about one kilogram per batch. ...
Breaking Biology Technology:Pittcon 2015 Announces Exposition Highlights 2One Million Acts of Innovation Canada Creates Partnership with The Economist Events’ Innovation Forum 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3Regis Extends cGMP Services to Oncology Market 2
... Cover the Use of Pharsight Software for In-Vitro / ... Correlation Modeling ... Pharsight(R),Corporation (Nasdaq: PHST ), a leading provider ... drug,development, today announced that Jason Chittenden, MS, Director of,Training ...
... (Nasdaq:,INSM), a developer of follow-on biologics and biopharmaceuticals, ... before The NASDAQ Listing,Qualifications Panel (,the Panel") to ... common stock from The NASDAQ Capital Market., ... Market ("NASDAQ") on,June 17, 2008 indicating that the ...
... / b3c newswire /  - Rentschler Biotechnologie, ... Arzneimittel gibt die Inbetriebnahme einer 2.500 Liter ... über neun unabhängige GMP-Produktionslinien mit Arbeitsvolumen von ... die Herstellung von klinischen Prüfmustern und für ...
Cached Biology Technology:Pharsight to Present on IVIVC at Bioequivalence & Bioavailability Strategies Conference 2Pharsight to Present on IVIVC at Bioequivalence & Bioavailability Strategies Conference 3Insmed to Request Hearing Before NASDAQ Panel to Review NASDAQ Staff Determination 2Rentschler Biotechnologie erweitert Kapazitten fr Produktion in Sugetierzellen 2
The filter 640DF35 for the Molecular Imager FX is a band pass filter for Texas Red dye....
The filter 605DF50 for the Molecular Imager FX is a band pass filter for ethidium bromide, SYPRO Red, SYPRO Ruby, Alexa Fluor 532 and 546, and Cy3 dyes when using the 635 nm laser....
... BioGenex VISION Sytem is a highly ... with proprietary digital imaging and automation ... image acquisition, analysis, archving/retrieval and colored ... state-of-the-art digital imaging system that aids ...
... ApopTag Fluorescein Direct In Situ ... cells in situ by the ... fragments are tagged with a ... kit provides fluorescence staining for ...
Biology Products: