Widely prescribed medications are often taken to influence all of these issues, especially when efforts to control them with diet, exercise, and proper weight have not been effective. However, some of these medications have unwanted side effects that remain a concern.
In this research, it was found that supplements of lipoic acid appeared to affect triglyceride levels through two pathways. After eating, lipoic acid supplementation increased the rate of disappearance of triglycerides in the bloodstream. And supplements also reduced the genetic expression of enzymes in the liver that synthesize triglycerides.
This is the first study that has identified the molecular targets by which lipoic acid can lower triglyceride levels, the researchers said, and to show the effect on liver enzymes resulting in less production of triglycerides. It also found that the mechanism of action of how lipoic acid can lower triglycerides appears separate and distinct from that provided by fibrate drugs, a group of prescription medications often used for that purpose.
Lipoic acid supplements have in various studies been shown to be an appetite suppressant, but control groups of laboratory animals were used in this research to ensure that lower triglyceride levels were not the result simply of less food intake.
The rats used in the experiment were obese to begin with, and developed higher triglyceride levels as the experiment proceeded and they aged but the animals given lipoic acid fared much better. As they grew from five weeks of age to nine weeks, the blood triglyceride levels doubled in rats given
|Contact: Regis Moreau|
Oregon State University