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New application of physics tools used in biology
Date:2/7/2014

to the activation or deactivation of signaling pathways that can lead to tumor formation," Xing added.

The molecular mechanism underlying epigenetic memory involves complex interactions between histones, DNA and enzymes, which produce modification patterns that are recognized by the cell. To gain insight into such complex systems, the team constructed a mathematical model that captures the essential features of the histone-induced epigenetic memory. The model highlights the "engineering" challenge a cell must constantly face during molecular recognition. It is analogous to restoring a picture with missing parts. The molecular properties of a species have been evolutionarily selected to allow them to "reason" what the missing parts are based on incomplete information pattern inherited from the mother cell.


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Contact: Anne Stark
stark8@llnl.gov
925-422-9799
DOE/Lawrence Livermore National Laboratory
Source:Eurekalert

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