Navigation Links
New antidepressant acts very rapidly and is long lasting
Date:12/7/2012

A first-of-its-kind antidepressant drug discovered by a Northwestern University professor and now tested on adults who have failed other antidepressant therapies has been shown to alleviate symptoms within hours, have good safety and produce positive effects that last for about seven days from a single dose.

The novel therapeutic targets brain receptors responsible for learning and memory -- a very different approach from existing antidepressants. The new drug and others like it also could be helpful in treating other neurological conditions, including schizophrenia, bipolar disorder, anxiety and Alzheimer's disease.

The results of the phase IIa clinical trial were presented today (Dec. 6) at the 51st Annual Meeting of the American College of Neuropsychopharmacology in Hollywood, Fla.

Also this week, a paper reporting some of the background scientific research that provided the foundation for the clinical development of GLYX-13 was published by the journal Neuropsychopharmacology.

The compound, called GLYX-13, is the result of more than two decades of work by Joseph Moskal, research professor of biomedical engineering at Northwestern's McCormick School of Engineering and Applied Science and director of the University's Falk Center for Molecular Therapeutics.

"Our study showed that this compound is capable of eliciting a robust and rapid antidepressant effect without the typical side effects seen with other drugs that also modulate the NMDA receptor," said Moskal, who is founder and chief scientific officer of the Evanston-based biotechnology company Naurex Inc., which conducted the clinical study.

GLYX-13 works by modulating the NMDA (N-methyl-D-aspartate) receptor in the brain, as do current NMDA receptor antagonists such as ketamine, but GLYX-13 does not have their serious and limiting side effects, such as hallucinations and schizophrenia-like effects. (An antagonist is a substance that inhibit
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Brain signal IDs responders to fast-acting antidepressant
2. Research finds heart remodeling rapidly follows cardiac injury
3. New study reveals lions are rapidly losing ground in Africa
4. Bears, scavengers count on all-you-can-eat salmon buffet lasting for months
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)...  Since its launch in December 2014, the 1U™ ... of trying to remember their usernames and passwords through replacing ... smartphones. To assist people who have struggled to remember usernames ... 1U and focuses on redefining identity, announced today that it ...
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the addition ... Systems Market" report to their offering. ... security market is estimated to grow at a CAGR of ... a larger share in this market, Canada ...
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... introducing expression of a special green-algae gene into ... researchers have been able to elicit specific behavioral ... The work paves the way for better understanding ... with muscles, to regulate behavior in intact, living ...
... the film classic "Flowers for Algernon," but adds a happy ... drugs, to reverse the attention deficits linked to the leading ... of Current Biology reports the findings, which were studied in ... , The results proved so hopeful, that the ...
... A team of scientists led by Priscilla Cooper, a ... the Department of Energy's Lawrence Berkeley National Laboratory, has ... repair (TCR), an essential but still mysterious mechanism of ... information from a cell's DNA is being transcribed into ...
Cached Biology News:Algal protein in worm neurons allows remote control of behavior by light 2Recreating 'Flowers for Algernon' with a happy ending 2Recreating 'Flowers for Algernon' with a happy ending 3Discovering the first steps in transcription-coupled repair 2Discovering the first steps in transcription-coupled repair 3Discovering the first steps in transcription-coupled repair 4Discovering the first steps in transcription-coupled repair 5Discovering the first steps in transcription-coupled repair 6
(Date:1/22/2015)... COLUMBIA, Md. (PRWEB) January 22, 2015 ... of its new UV-1280 multipurpose UV-visible spectrophotometer. Offering ... compact, high-quality instrument is ideal for applications in ... and life science. , The user-friendly UV-1280 enables ...
(Date:1/22/2015)... The laboratory information management systems market is a ... technological advancements due to factors such as rising pressure ... healthcare systems, and increasing government support for adoption of ... players in the market focus on technological advancements to ...
(Date:1/22/2015)... WI (PRWEB) January 22, 2015 Dr. Greg ... the 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics ... Conference is an annual continuing education conference for health care ... and included the topic of probiotics in health. Dr. Leyer ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, ... Sequenom, Inc. (NASDAQ: SQNM ), the ... agreement for next generation noninvasive prenatal tests (NIPT). ... interpretation technology, called Mantis™, to advance analysis of ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... Calif., Oct. 29 Genomic Health,Inc. (Nasdaq: GHDX ... conference,call and webcast on Wednesday, November 5, 2008 at ... financial results. The call and webcast,will follow the release ... Conference Call Details, To access the live conference ...
... 29 DURECT Corporation,(Nasdaq: DRRX ) ... license agreement with Alpharma Ireland Limited, an ... granting such party the exclusive worldwide,rights to ... patch, has cleared review under the,Hart-Scott-Rodino (HSR) ...
... Confirmation of Annual and Special General Meeting of Shareholders ... ANPI , TSX: ANP), a global specialty pharmaceutical ... its,financial results for the third quarter ended September 30, ... (8:00 AM Pacific)., The Company,s Annual and Special ...
Cached Biology Technology:Genomic Health to Announce Third Quarter 2008 Financial Results and Host Conference Call on Wednesday, November 5, 2008 2DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 2DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 3DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 4Notice of conference call and webcast 2