Navigation Links
New anticoagulant discovered based on the same used by malaria vectors to feed on
Date:12/11/2012

An international project lead by the Molecular and Cell Biology Institute of Porto University with the participation of researchers from IMIM (Hospital del Mar Medical Research Institute) has, for the first time ever, deciphered the mechanism by which a substance called anophelin binds to an enzyme (thrombin) involved in the process of blood coagulation. This discovery was published in the last issue of the PNAS journal and opens the door to, on the one hand, designing a new generation of anticoagulant drugs with a totally different functioning to current ones and, on the other hand, fighting against the spreading of malaria by designing inhibitors for this substance.

Anophelin is a substance playing a crucial role in the nutrition of a large number of parasites like malaria-carrying Anopheles mosquitoes or vampire bats. These animals need to feed on fresh blood and stop it from coagulating while they are eating. To make this possible, they use powerful inhibitors of the coagulation process mainly affecting thrombin. Researchers have discovered that "anophelin blocks thrombin in a new and different way than other substances: it's like a key fitting in a lock of a door, but in this case the key fits in the other side" explains Ricardo Gutirrez Gallego, a member of the IMIM Bioanalysis research group.

The project is based on two recent studies which led to the discovery of thrombin inhibitors presenting new structures. For the inhibitor produced by Anopheles mosquitoes (anophelin), it was seen that after binding to thrombin, proteins did not degrade, so a systematic study was launched for all coagulants in the several variants of the Anopheles mosquito. By using very powerful and sensitive analytical techniques it was possible to determine and monitor in real time the molecule interactions in both anophelin and thrombin, leading to a detailed characterization of their structure and interaction. Researchers also performed mutations on thi
'/>"/>

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Medical Research Institute)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Global Market for Blood Banking and Blood Products Projected to reach $43 billion by 2018; Spectrometers and Fluorometers to Reach $18.4 bn; Anticoagulants to Reach $12.9 bn; Cell and Tissue Culture Supplies to Reach $5.6 bn
2. Hearty organisms discovered in bitter-cold Antarctic brine
3. Microbial missing link discovered after man impales hand on tree branch
4. Newly discovered effects of vitamin D on cancer
5. Missing link discovered in the defence mechanism of the tuberculosis pathogen
6. New cause of thyroid hormone deficiency discovered
7. Undersea gas leaks off Israels coast are discovered by University of Haifa researchers
8. Sweet new approach discovered to help produce metal casting parts, reduce toxicity
9. 9 colorful and endangered tree-dwelling tarantulas discovered in Brazil
10. New genes discovered for adult BMI levels
11. Living power cables discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
(Date:7/11/2014)... toxins to study the proteins that let nerve cells ... have stumbled upon a biological tactic that may offer ... in a safe and environmentally responsible way. , ... for one species and harmless for a closely related ... pests without harming beneficial species like bees. A summary ...
(Date:7/10/2014)... other major cities in New Mexico, nearly every public ... rather than precious potable water supplies. Across the U.S. ... golf courses receive treated effluent. Reusing the effluent increases ... courses and homeowners alike fertilize their lawns during the ... A New Mexico State University turfgrass expert has a ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3'Tailored' water -- the latest in lawn care 2
... the saliva of the Gila monster lizard is effective ... Sahlgrenska Academy, University of Gothenburg, have tested the drug ... both food and chocolate. An increasing number of ... pharmaceutical preparation called Exenatide, which helps them to control ...
... reporting estimates of the prevalence of sexually transmitted infections/reproductive ... years suggests that a considerable burden of malaria and ... facilities in sub-Saharan Africa, according to a review and ... issue of JAMA , a theme issue on ...
... of tiger snakes stranded for thousands of years on tiny ... nearly twice the size of their mainland cousins. Now, new ... enormity of these elapids was driven by the need to ... out at 35 inches (89 cm) long, patrol swampy areas ...
Cached Biology News:Drugs from lizard saliva reduces the cravings for food 2Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa 2Big-mouthed babies drove the evolution of giant island snakes 2Big-mouthed babies drove the evolution of giant island snakes 3
(Date:7/10/2014)... UK (PRWEB) July 10, 2014 ... 21st Century Medicine Forum on ‘Commercialising Longevity Research’ ... and entrepreneurs to the London Bioscience Innovation Center ... Research Foundation and Aging Analytics Ltd. The meeting ... investment in translational research for age-related disease, as ...
(Date:7/10/2014)... July 10, 2014 Terascala, the industry ... that Alan Swahn, a former vice president of product ... as vice president of marketing. Terascala’s software when combined ... NetApp create the highest performance and most reliable solutions ... to guide Terascala’s channel expansion and broaden its product ...
(Date:7/10/2014)... July 10, 2014 Robert Harman, DVM, Founder ... company, is proud to announce the relaunch of his highly ... a new series called “ What are Stem Cells ?” ... honest and straightforward foundation in the basics of stem cell ... on the right type of treatment when considering regenerative medicine. ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has ... now comes with a second treatment cup to help prevent ... new cup is thinner on the edges for a softer ... thin and uneven surfaces on the face, neck and décolleté. ... treatment on areas such as the cheeks and neck, or ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2
... Advanced Technology Drives Ongoing Live-Cell Research, ... Inc., (http://www.nikoninstruments.com ) and Northwestern University,s Feinberg ... collaborative core microscopy imaging,center, establishing a partnership ... providing critical feedback for Nikon,product development. One ...
... ExonHit Therapeutics, a drug,and diagnostic company, today ... on July 1st as Chief Operating Officer. At ... be appointed CEO (President du,Directoire)., Laurent Condomine, ... to have Loic Maurel joining ExonHit Therapeutics. His,experience ...
... infected with HIV the virus infects cells in the ... Although this causes no immediate problems, during the late-stages ... inflammation of the brain that can cause death). Monkeys ... develop CNS damage and provide a good model of ...
Cached Biology Technology:Nikon Instruments Opens New Imaging Center at Northwestern University 2Nikon Instruments Opens New Imaging Center at Northwestern University 3Loic Maurel Joins Exonhit Therapeutics to Become CEO 2Loic Maurel Joins Exonhit Therapeutics to Become CEO 3Loic Maurel Joins Exonhit Therapeutics to Become CEO 4
... for paramagnetic bead precipitation from standard 96-well ... with no additional accessories. The stand has ... SBS 96-well microplate footprint. The use of ... and fast (as little as 30 seconds) ...
... a personal desktop unit ideal for use in ... Rotation speed set at 12 rpm ... , Bottle capacity of four 35 x ... conical ,plastic bottles , Consistent, repeatable results ...
... The DNA120OP is specifically engineered for ... sturdy design incorporates a glass cover and ... fully automated, unattended, odor-free processing of samples ... System for Synthetic Oligos ...
... SpeedVac to have active, real-time sample temperature ... is the worlds first, fully modular SpeedVac ... stacked together to form an integrated unit ... is also the first SpeedVac to have ...
Biology Products: