Navigation Links
New antibiotic candidates from Braunschweig
Date:10/17/2008

This press release is available in German.

A group of antibiotic natural products discovered at the Helmholtz Centre for Infection Research (HZI) in Braunschweig points out a new mode of action against pathogenic bacteria. Isolated from myxobacteria, the substances prevent an enzym of the pathogens from being able to translate their genetic material. In this way, the propagation of bacteria such as tuberculosis pathogens - is inhibited. A working group at Rutgers University in New Jersey (USA) has now joined up with HZI researchers and discovered in detail how these compounds interact with the target in pathogenic bacteria. The novel target is different from the target of known antibiotics such as rifamycin, a standard medication to counteract tuberculosis.

This discovery makes the Braunschweig natural products extremely interesting candidates for a development as antibiotics especially in view of the fact that the substances also kill bacterial strains that are resistant to antibiotics. Today, the scientists publish their results in the distinguished journal "Cell".

Antibiotics are an essential tool of medicine. We owe the antibiotics that diseases such as plague, cholera or tuberculosis are a thing of the past, at least in the industrialised world.

However, more and more bacteria are becoming resistant to medication. Consequently, doctors are in urgent need of new antibiotics. Their development is a demanding challenge: the drugs should attack the bacteria only but not interact with human cells. Subsequently, the number of effective antibiotic targets in bacteria is severely limited; every new active compound is warmly welcomed by the antibiotics researchers, especially if it highlights a new mode of action.

In the search for candidates which might be developed into such novel medicines the HZI enjoys a strong advantage:
'/>"/>

Contact: Hannes Schlender
hannes.schlender@helmholtz-hzi.de
49-531-618-11400
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Groundbreaking discovery may lead to stronger antibiotics
2. New way to make malaria medicine also first step in finding new antibiotics
3. Milk may help bacteria survive against low levels of antibiotics
4. Energy-saving bacteria resist antibiotics
5. Class of antibiotics can enhance gene-silencing tool
6. New antibiotic beats superbugs at their own game
7. Test of bacteria toxin delivery system could pave way for new antibiotic drugs
8. Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain
9. UIC scientists discover how some bacteria survive antibiotics
10. NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic
11. Unique fungal collection could hold key to future antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/8/2015)... June 8, 2015  The Secure Identity ... selection of Troy Potter of L-3 ... SIBA is a non-profit association that was established ... education and implementation of solutions that protect and ... ...
(Date:6/4/2015)... 2015  Today, the co-chairs of the Blue Ribbon Study ... biocontainment labs and USA Today,s ... concerns over the findings of lax safety standards and called ... "The state ... said Joe Lieberman , former senator and co-chair of ...
(Date:6/1/2015)... 1, 2015 According to ... Market by Application (Government, Military & Defense, Healthcare, ... and Security), Technology (Face Recognition, Fingerprint Recognition, Iris ... Recognition, and Others), Function (Contact and Non-Contact) & ... Europe , APAC, Row) - Global ...
Breaking Biology News(10 mins):Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 3Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 4Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 5Biodefense Panel Expresses Grave Concerns over Findings at Nation's Research Labs 2Biodefense Panel Expresses Grave Concerns over Findings at Nation's Research Labs 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4
... In the largest clinical trial to date to examine ... carriers with diseases other than breast and ovarian cancer, ... against advanced pancreatic and prostate cancers. Results of the ... Medicine at the University of Pennsylvania and Sheba Medical ...
... Ocean frontier explorer and world-renowned filmmaker James Cameron has ... San Diego as the recipient of the 2013 Nierenberg ... deliver a presentation on his record-setting DEEPSEA CHALLENGE expedition ... on Friday, May 31, on the UC San Diego ...
... have developed guidelines being used by foresters and the ... when planting trees., Maps developed by Laura Gray, a ... projections of climatically suitable habitat for tree species based ... , The work, published recently in the journal ...
Cached Biology News:PARP inhibitor shows activity in pancreatic, prostate cancers among patients carrying BRCA mutations 2James Cameron to be publicly honored with Scripps Nierenberg Prize 2James Cameron to be publicly honored with Scripps Nierenberg Prize 3James Cameron to be publicly honored with Scripps Nierenberg Prize 4
(Date:6/29/2015)... 2015  AACC, a global scientific and medical ... medicine, is pleased to announce that the impact ... has increased to 7.9 in the 2014 Thomson ... Clinical Chemistry in the top 3% of ... of the research it publishes on laboratory medicine ...
(Date:6/29/2015)... ... 29, 2015 , ... The StampedeCon 2015 Big Data Conference will ... in a row, will bring top technology professionals to St. Louis. Top industry speakers ... data and technology. The event is proudly sponsored by DataStax, Cisco, World Wide Technology, ...
(Date:6/26/2015)... , June 26, 2015  SeraCare Life Sciences, ... manufacturers, today announced that it has signed a ... National Cancer Institute (NCI), part of the National ... positive controls for cancer assays.  The CRADA will ... accurately quantitate control DNA biosynthetics spiked into a ...
(Date:6/26/2015)... June 26, 2015  A San Francisco company, Pembient, ... with synthetic rhino horn: beer in China ... . In response to the emerging industry, two ... and sale of synthetic rhino horn.  ... Save the Rhino International (SRI) released a ...
Breaking Biology Technology:AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3StampedeCon Announces 2015 Agenda 2StampedeCon Announces 2015 Agenda 3SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... engineers across Wisconsin are learning new ways to ... sugars, soybeans, solar collectors, corn stover, wind farms, ... , ,State businesses, architects, and builders are national ... save energy and money. , ,Wisconsin policymakers and ...
... after the launch of wireless Internet service in downtown Madison, ... service offered by area coffee shops. , ,Now, Mad ... 10-block radius of Madison's Capitol Square and at Dane ... of them. The broadband service will add indoor wireless access ...
Whitewater, Wis . - Sharon Ethanol , a subsidiary of <a...
Cached Biology Technology:Wisconsin can offer what a federal energy research lab needs 2Wisconsin can offer what a federal energy research lab needs 3Wisconsin can offer what a federal energy research lab needs 4