Navigation Links
New anti-tumor cell therapy strategies are more effective
Date:10/25/2012

New Rochelle, NY, October 25, 2012Targeted T-cells can seek out and destroy tumor cells that carry specific antigen markers. Two novel anti-tumor therapies that take advantage of this T-cell response are described in articles published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available free on the Human Gene Therapy website at http://www.liebertpub.com/hum.

Richard Morgan and colleagues from the National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, and Duke University Medical Center, Durham, NC, used engineered T-cells to attack glioma stem cells, which are one of the cell types present in glioblastoma, an aggressive and fatal type of brain cancer. There is no curative treatment for glioblastoma, and patients usually live less than two years from diagnosis. In the article "Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma," the authors describe how targeting tumor stem cells, in combination with traditional therapies aimed at killing other types of glioma tumor cells, could improve the effectiveness of treatment and reduce tumor recurrence.

In a related article, Karen Kaluza and coauthors, Mayo Clinic, Rochester, MN, conducted a study using T-cells capable of recognizing two different antigens simultaneously and showed that this dual targeting strategy could be more effective at clearing tumor cells and reducing the risk of "tumor escape" and cancer recurrence. In "Adoptive Transfer of Cytotoxic T Lymphocytes Targeting Two Different Antigens Limits Antigen Loss and Tumor Escape," the authors conclude that T-cell therapies targeting two or more antigens will have significant added value compared to single-antigen therapies.

"These studies represent important advances in the development of novel treatments for cancer that combine the power of gene transfer and cell transplantation," says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.


'/>"/>
Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
5. Researchers discover novel therapy for Crohns disease
6. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
7. Cell therapy using patients own bone marrow may present option for heart disease
8. Harmless human virus may be able to boost the effects of chemotherapy
9. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
10. Nanobubbles plus chemotherapy equals single-cell cancer targeting
11. New data suggests interferon-free therapy around the corner for HCV patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New anti-tumor cell therapy strategies are more effective
(Date:2/16/2017)... FRANCISCO , Feb. 16, 2017  Genos, ... today announced that it has received Laboratory Accreditation ... CAP Accreditation is presented to laboratories that meet ... who demonstrate scientifically rigorous processes. "Genos ... excellence in laboratory practices. We,re honored to be ...
(Date:2/9/2017)... The biomass boiler market report by Transparency Market Research ... in terms of revenue (US$ Mn) based on the ... boilers has been segmented on the basis of feedstock ... based on feedstock type, has been segmented into woody ... urban residues, and others. On the basis of product ...
(Date:2/8/2017)... Report Highlights The global biosurgery market should ... 2016 at a compound annual growth rate (CAGR) of ... An overview of the global market for biosurgery. - ... and 2016, and projections of compound annual growth rates ... the basis of product type, source, application, and region. ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; ... three months ended December 31, 2016. SQI ... diagnostics company that develops and commercializes proprietary technologies and products ... ... commercial milestones achieved in fiscal 2016," said Andrew Morris ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... and development (R&D), today announced the establishment of Genedata Limited as a new ... Teburi, a recognized expert in life science informatics. Creating the UK subsidiary reinforces ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... Treximo will pair its $200M operational capacity with its strategic internal leadership ... in areas affecting quality and operational management. With office locations in ...
(Date:2/21/2017)... BOTHELL, Wash. and VANCOUVER, British Columbia ... OGXI ) today announced that apatorsen results from ... American Society of Clinical Oncology (ASCO) 2017 Genitourinary Cancers Symposium, ... Orlando . Clinical data from trials in bladder ... outcomes when administered in combination with standard-of-care treatments. ...
Breaking Biology Technology: