Navigation Links
New anti-HIV gene therapy makes T-cells resistant to HIV infection
Date:1/26/2011

New Rochelle, NY, January 26, 2011An innovative genetic strategy for rendering T-cells resistant to HIV infection without affecting their normal growth and activity is described in a paper published in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The paper is available free online at www.liebertpub.com/hum

A team of researchers from Japan, Korea, and the U.S. developed an anti-HIV gene therapy method in which a bacterial gene called mazF is transferred into CD4+ T-cells. The MazF protein is an enzyme (an mRNA interferase) that destroys gene transcripts, preventing protein synthesis. The design of this mazF gene therapy vector ensures that synthesis of the MazF protein is triggered by HIV infection. When HIV infects treated T lymphocytes, MazF is induced, blocking HIV replication and, essentially, making the T-cells HIV resistant.

This elegant gene therapy tool was developed by Hideto Chono and colleagues from Takara Bio Inc. (Otsu, Shiga, Japan), Seoul National University and ViroMed Co. (Seoul, Korea), National Institute of Biomedical Innovation (Tsukuba, Ibaraki, Japan), and Robert Wood Johnson Medical School (Piscataway, NJ). The authors describe the theory and science behind this strategy in the paper entitled, "Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-Specific E. coli mRNA Interferase."

"The potential of using vectors to express genes within a cell to block viral infection was first considered by David Baltimore in a strategy called 'intracellular immunization.' This study illustrates a unique way in which intracellular immunization can be achieved," says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related biology news :

1. Researchers report on the early development of anti-HIV neutralizing antibodies
2. Designing more effective anti-HIV antibodies
3. Peregrine reports new study from Duke shows anti-HIV potential of targeting PS on cells
4. Einstein to develop anti-HIV drug delivery system
5. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
6. Bodys anti-HIV drug explained
7. Caffeine energizes cells, boosting virus production for gene therapy applications
8. Nanodisk gene therapy
9. Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy
10. New breathing therapy reduces panic and anxiety by reversing hyperventilation
11. Missing molecules hold promise of therapy for pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New anti-HIV gene therapy makes T-cells resistant to HIV infection
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... about the way our bodies are assembled during early ... they are supposed to become a nerve or a ... correct place and alignment? Researchers at the University of ... a new study, UM researchers describe the signaling systems ... at the head-trunk region. Their discovery may have important ...
(Date:11/4/2014)... Lithuania , Nov. 4, 2014   ... technologies, today announced that the latest version of ... in the Ongoing MINEX evaluation organized ... of fingerprint algorithms using the INCITS 378 fingerprint ... mandatory requirement in public tenders in ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... Although a recent study suggests that women with normal ... and older may wait up to 15 years for a ... Journal of Bone and Mineral Research (JBMR) cautions that ... Viewpoints allow experts to provide a new perspective on research. ...
... scientists have been awarded $3.1 million by the National ... of Health, to study and develop several new compounds ... without the unwanted side effects common with opiate drugs, ... Bohn, an associate professor in the Department of Molecular ...
... Ridge National Laboratory,s Jaguar supercomputer has completed the ... it among the most powerful scientific computing systems ... upgrade was completed earlier this month. The testing ... dynamics, high-temperature superconductivity, nuclear fusion, and combustion. ...
Cached Biology News:Osteoporosis experts urge bone density testing more frequently for women at risk 2Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments 2ORNL completes first phase of Titan supercomputer transition 2
(Date:11/22/2014)... 21, 2014 Prominent academics, leaders ... gather on December 3rd at Genetic Rx, a ... GeneticRx will take place at the Joseph B. ... will discuss the present and future of genetic ... and gene editing—as well as the treatment of ...
(Date:11/22/2014)... 22, 2014 The “Chiral Chromatography ... by Material (Metal, Glass, Plastic), by Application [GC, ... - Forecast to 2018” analyses and studies the ... North America, Europe, Asia, and Rest of the ... 15 figures spread through 135 pages and in-depth ...
(Date:11/21/2014)... November 21, 2014 , ...   Mariano Rodríguez es elegid vicepresidente senior ... KLOX está en marcha para comenzar de forma rápida ... heridas de reciente aprobación en Europa   , ... complace al anunciar los siguientes nombramientos: Todd ...
(Date:11/21/2014)... Author Matthew J. Pallamary’s second short ... Side” published as a tribute to his mentor ... Short Story” category of the 2014 USA Best ... of USA Book News, said this year’s contest yielded ... Simon & Schuster, Penguin, John Wiley & Sons, Houghton ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4
... I wrote on an article on "The Final Death Knell ... on the walls of the demise of Searle due to ... Searle facilities in Chicago. Since then, the Searle name has ... another article I wrote on May 16, 2005, titled " ...
... Madison Area Technical College's Network Security Specialist ... and other threats to computer systems and data, has earned ... National Security Systems . , ,It is only one of ... high-level certification. MATC had to match its curriculum precisely to ...
... attract the presence of major pharmaceutical companies from out ... own environment, said a panel assembled Monday night by ... building the future today in Wisconsin has to do ... CEO Irene Hrusovsky. , ,Woody Hydrick, a senior consultant ...
Cached Biology Technology:Searle spirit lives on in Chicago as alumni celebrate at former home 2Searle spirit lives on in Chicago as alumni celebrate at former home 3Searle spirit lives on in Chicago as alumni celebrate at former home 4Searle spirit lives on in Chicago as alumni celebrate at former home 5Panel stresses drawing outside biotech firms to state 2
UGT1A7 (E-15)...
... nucleofection of optimized cell lines in combination ... nucleofection parameters. Nucleofector Kits are only functional ... cell lines can be transfected with this ... given in brackets in percent (Efficiency [%] ...
... Fluorescein 6-Fam, Hex, Tet Cy3, Cy5, ... Tamra Black Hole Quenchers Molecular Beacons* ... Tamra, Joe 3 Dabcyl Dabcyl*Licensed ... York Double labelled probes are purified either ...
... Protein Phosphatase ( l-PPase) ... phosphatase with activity towards ... tyrosine residues. It is ... of the ORF221 open ...
Biology Products: