Navigation Links
New and unexpected mechanism identified how the brain responds to stress
Date:3/2/2009

Calgary, AB -- Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain. Being able to quickly and successfully respond to stress is essential for survival.

Using a rat model, Jaideep Bains, PhD, a University of Calgary scientist and his team of researchers at the Hotchkiss Brain Institute have discovered that neurons in the hypothalamus, the brain's command centre for stress responses, interpret 'off' chemical signals as 'on' chemical signals when stress is perceived. "It's as if the brakes in your car are now acting to speed up the vehicle, rather than slow it down." says Bains. This unexpected finding is being published in the March 1st online edition of Nature Neuroscience.

Normally, neurons receive different chemical signals that tell them to either switch on or switch off. The off signal or brake only works if the levels of chloride ion in the cells are maintained at a low level. This is accomplished by a protein, known as KCC2. What Bains and colleagues have shown is that stress turns down the activity of KCC2, thus removing the ability of the brake, a chemical known as GABA, to work properly. A loss of the brain's ability to slow down may explain some of the harmful, emotional consequences of stress.

While the findings provide a new mechanistic explanation of how the brain interprets stress signals, "there is still much work needed in the basic science of this phenomenon before there are any new advances in the medical treatment of stress," says Bains

"This opens entirely new and quite unexpected avenues for controlling stress responses" says Yves De Koninck, PhD, president-elect of the Canadian Association for Neuroscience and professor of Psychiatry at Laval University.

"I was fascinated when I learned of this work. It has not been clear till now
'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coral reef fish harbor an unexpectedly high biodiversity of parasites
2. Amazon forest shows unexpected resiliency during drought
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Quakes under Pacific floor reveal unexpected circulatory system
5. Researchers explore altruisms unexpected ally -- selfishness
6. Plant biologists discover unexpected proteins affecting small RNAs
7. UT Knoxville professor finds unexpected key to flowering plants diversity
8. Unexpected large monkey population discovered
9. Study of placenta unexpectedly leads to cancer gene
10. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
11. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... USA - The rise of the Tibetan plateau -- ... -- is important for both its profound effect on ... study published in GSA Bulletin , Katharine Huntington ... isotope thermometry -- using modern and fossil snail shells ... in southwestern Tibet. , Views range widely on ...
(Date:8/28/2014)... bacterial culprits that may drive inflammatory bowel diseases (IBD) ... own intestinal immune responses as a guide. , The ... Cell . , Trillions of bacteria exist within the ... the development and progression of IBD. Yet it,s thought ... a person,s susceptibility to IBD and its potential severity. ...
(Date:8/28/2014)... neighbors than traditional cigarettes, but still release toxins ... from USC. , Scientists studying secondhand smoke from ... to harmful particles, with close-to-zero exposure to organic ... metals in second-hand e-cigarette smoke were found to ... high levels of polycyclic aromatic hydrocarbons cancer-causing ...
Breaking Biology News(10 mins):Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Yale study identifies possible bacterial drivers of IBD 2Second-hand e-cig smoke compared to regular cigarette smoke 2
... a common genetic disorder previously linked to lung disease ... lung cancer, according to a report in the May ... the JAMA/Archives journals. The disorder, alpha1-antitrypsin deficiency (1ATD), ... the U.S. population and especially those of European descent, ...
... NEW YORK (May 23, 2008) A study led ... Columbia University Medical Center/NewYork-Presbyterian and chairman of the Cardiovascular ... were administered the direct thrombin inhibitor bivalirudin during primary ... a lower rate of major bleeding, and a lower ...
... Institute of Pacific Islands Forestry have submitted a proposal ... of strawberry guava, a South American tree that has ... introduced in 1825 as a garden plant. The scientists ... Land and Natural Resources, and Hawai Department of Agriculture, ...
Cached Biology News:Genetic mutation associated with increased risk of lung cancer 2Findings released from 1 of the largest percutaneous coronary intervention trials ever 2Insect release proposed to control exotic strawberry guava 2
(Date:8/29/2014)... Burnt Hills, NY (PRWEB) August 29, 2014 ... at Burnt Hills Veterinary Hospital are seeking candidates to ... for dogs with osteoarthritis. The ultimate goal of ... of donor stem cells into one or two arthritically ... the treated joints. , Candidates for the current ...
(Date:8/29/2014)... August 29, 2014 Intrinsic Imaging, ... certified, GAMP® 5 compliant imaging core lab, announced ... Phase II clinical trial to assess a new ... this trial, Intrinsic Imaging will provide comprehensive imaging ... protocol and charter development, site qualification, site training ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides users ... said Mark Tess, PhD, Mycotoxin Product Manager for Charm Sciences. ... USDA-GIPSA inspection agencies that have a need to detect aflatoxin ... a matter of minutes with nothing but our equipment and ... grain before accepting it, but they no longer have to ...
(Date:8/28/2014)... PA (PRWEB) August 28, 2014 The ... create a culture that will allow individuals to perform ... becoming increasingly important for employers looking to compete in ... industries are embracing this trend, as the sector increasingly ... of a company, which will have real results on ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3
... - Companies that operate in the clean technology industry ... soon will have the opportunity to impress the 600 investors ... Capital Forum in San Francisco. , , Orion Energy ... Madison are among 20 emerging clean technology companies that will ...
... fellow travelers a thing or two about commuting. , ,The ... an executive-in-residence and one of its portfolio companies, Caden ... , Gregg Fergus And since Fergus has been ... his new posts reduce the distance between home and work. ...
... a judge for an industry award contest. It wasn't the Oscars. ... conference room at the Sheraton at Los Angeles International Airport ... of this year's Medical Design Excellence Awards (MDEA). , ... MDEA winners may very well save your life some day. , ...
Cached Biology Technology:Biotech executive books a career flight that's closer to home 2Biotech executive books a career flight that's closer to home 3And the winners in medical design are 2And the winners in medical design are 3And the winners in medical design are 4And the winners in medical design are 5And the winners in medical design are 6
Request Info...
... the consumable measurement plate for ... individually controlled measurement sites. Each ... liquid flow channel system that ... solution and compound applications necessary ...
... application capable of dynamic scheduling, is designed ... lab automation workcells easy for lab personnel, ... programmers. • Users create methods ... you can build a flowchart, you can ...
... to grow, the need for greater detection ... necessary, especially when discerning very similar or ... Confocal Microscope System gives you a level ... available in conventional confocal systems, with detectors ...
Biology Products: