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New alterations found in young adults with type 2 diabetes
Date:3/11/2010

This release is available in Spanish.

Diet and aerobic exercise are highly effective for the treatment of type 2 diabetes, but not for obese subjects that have developed the disease when very young. A study at the Institute for Research in Biomedicine (IRB Barcelona) and Trinity College in Dublin demonstrates that obese subjects between 18 and 25 years of age carry mitochondrial proteins and genes that work abnormally and that these anomalies contribute to generating insulin resistance and a reduced response to physical exercise. Produced by the American Diabetes Association, the journal Diabetes Care, which disseminates the clinical studies of greatest relevance, will publish the results of this research in its March issue.

Diabetes type 2 is the most common form of diabetes worldwide and in Europe it accounts for almost 90% of the cases of this disease. In Spain, diabetes affects 6.5% of the population between the ages of 30 and 65. In type 2 diabetes tissues don't respond properly to insulin, a hormone produced by the pancreas, and the pancreas is not able to produce the abnormal amount required by the organism. Insulin serves to help tissues take up glucose carried by blood. Experts associate the appearance of diabetes type 2 with overweight, diet, and lack of exercise. "Until now most cases were registered in subjects over 50 years of age, but young people are increasingly developing the disease", explains Antonio Zorzano, co-author of the study and head of the Molecular Medicine programme at IRB Barcelona.

Zorzano goes on to explain that the results of the clinical study are relevant for two reasons. "We are starting to observe that there are special forms of diabetes type 2 that behave in a different way to the classical form, and these differences require specific treatments for each kind of patient." In another study published in
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Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

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